A5054274123- Migraine and Headache Studies
- Transcranial Magnetic Stimulation Studies
- Pain Management and Treatment
- Fibromyalgia and Chronic Fatigue Syndrome Research
- EEG and Brain-Computer Interfaces
- Heart Rate Variability and Autonomic Control
- Genetic Neurodegenerative Diseases
- Muscle activation and electromyography studies
- Trigeminal Neuralgia and Treatments
- Functional Brain Connectivity Studies
- Musculoskeletal pain and rehabilitation
- Laser Applications in Dentistry and Medicine
- Pain Management and Placebo Effect
- Neurological disorders and treatments
- Myofascial pain diagnosis and treatment
- Motor Control and Adaptation
- Olfactory and Sensory Function Studies
- Pain Mechanisms and Treatments
- Vagus Nerve Stimulation Research
- Infrared Thermography in Medicine
- Neurology and Historical Studies
- Vestibular and auditory disorders
- Sympathectomy and Hyperhidrosis Treatments
- Neural and Behavioral Psychology Studies
- Traumatic Brain Injury Research
University of Bari Aldo Moro
2015-2024
Advanced Neural Dynamics (United States)
2024
Sapienza University of Rome
2019
Università Campus Bio-Medico
2019
Istituto Nazionale di Fisica Nucleare, Sezione di Milano
2017-2018
Ospedale Pediatrico Giovanni XXIII
2016-2017
University of Salento
2014
Tio University
2013
University of Atlanta
2012
To evaluate the efficacy, safety, and tolerability of noninvasive vagus nerve stimulation (nVNS; gammaCore; electroCore, LLC, Basking Ridge, NJ) for acute treatment migraine in a multicenter, double-blind, randomized, sham-controlled trial.A total 248 participants with episodic with/without aura were randomized to receive nVNS or sham within 20 minutes from pain onset. Participants repeat if had not improved 15 minutes.nVNS (n = 120) was superior 123) freedom at 30 (12.7% vs 4.2%; p 0.012)...
Introduction: Pain perception is currently an open question in patients suffering from prolonged disorders of consciousness. The aim the present study was to examine nociceptive specific laser evoked responses (LEPs) view long-latency potentials by non-painful electrical stimuli (SEPs) and auditory mismatch negativity (MM).
Experimental and clinical studies suggested an analgesic effect on chronic pain by motor cortex activation. The present study explored the complex mechanisms of interaction between during performing slow fast finger tapping task alone in concomitant with nociceptive laser stimulation.The participants were 38 patients fibromyalgia (FM) 21 healthy subjects. We used a simultaneous multimodal method laser-evoked potentials functional near-infrared spectroscopy to investigate metabolic electrical...
To apply effective connectivity by means of nonlinear Granger Causality (GC) and brain networking analysis to basal EEG under visual stimulation checkerboard gratings with 0.5 2.0 cpd as spatial frequency in migraine aura (MA) without (MO), compare these findings Blood Oxygen Level Dependent (BOLD) signal changes.Nineteen asymptomatic MA MO patients 11 age sex matched controls (C) were recorded 65 channels. The same was employed evaluate BOLD changes a subgroup MO. GC applied signals.A...
In previous studies, migraine patients showed abnormalities in pain-related evoked responses, as reduced habituation to repetitive stimulation. this study, we aimed apply a novel analysis of EEG bands synchronization and directed dynamical influences under painful stimuli compared non-migraine healthy volunteers. Thirty-one without aura outpatients (MIGR) were evaluated 19 controls (CONT). The right hand was stimulated by means 30 consecutive CO2 laser stimuli. signal examined Morlet...
We propose a virtual reality (VR) model, reproducing house environment, where color modification of target places, obtainable by home automation in real ambient, was tested means P3b paradigm. The place (bathroom door) designed to be recognized during wayfinding realistic reproduction environment. Different and luminous conditions, easily obtained the ambient from remote control, were applied standard all doors being illuminated white (W), only colored with green (G) or red (R) spotlight....
A dysfunction of pain processing at central and peripheral levels was reported in fibromyalgia (FM). We aimed to correlate laser evoked potentials (LEPs), Sympathetic Skin Response (SSR), clinical features FM patients. Fifty patients 30 age-matched controls underwent LEPs SSR by the right hand foot. The evaluation included disability (FIQ) severity scores (WPI), anxiety (SAS) depression (SDS) scales, questionnaires for neuropathic (DN4). LEP P2 latency amplitude were increased group. This...
Fibromyalgia (FM) is a syndrome characterized by altered pain processing at central and peripheral level, whose pathophysiologic mechanisms remain obscure. We aimed exploring the structural changes of nociceptor measured skin biopsy, functional nociceptive pathway assessed laser-evoked potentials (LEP), their correlation with clinical features comorbidities.In all, 81 patients diagnosed FM underwent biopsies quantification intraepidermal nerve fibre density (IENFD) thigh distal leg, LEP...
Environmental context has an important impact on health and well being. We aimed to test the effects of a visual distraction induced by classical hospital waiting room (RH) versus ideal with sea view (IH), both represented in virtual reality (VR), subjective sensation cortical responses painful laser stimuli (LEPs) healthy volunteers patients chronic migraine (CM). Sixteen CM 16 controls underwent 62 channels LEPs from right hand, during fully immersive VR experience, where two types rooms...
Little knowledge is available about neural dynamics during natural motor behavior and its perturbation in aging neurological diseases. In the present study, we aim to evaluate electroencephalography-electromyography (EEG-EMG) co-registration features of rest walking basal condition under cognitive tasks normal subjects characterize a "normal gait" define possible paradigm detect abnormal behavior. We realized EEG-EMG 17 healthy different conditions: 1) sitting, 2) standing 3) walking. A P300...
Few studies have addressed central sensitization symptoms and pain processing in childhood migraine. Our aims were to examine sensitivity responses, including habituation, evoked by CO2 laser stimuli (laser-evoked potentials (LEPs)) a cohort of children with migraine compared non-migraine controls determine the correlation between LEP features signs sensitization.Thirty-five patients 8-15 years age migraines without aura evaluated during inter-critical phase 17 controls. LEPs analyzed, their...
Questions regarding perception of pain in non-communicating patients and the management continue to raise controversy both at a clinical ethical level. The aim this study was examine cortical response salient visual, acoustic, somatosensory electric non-nociceptive nociceptive laser stimuli their correlation with evaluation.Five Vegetative State (VS), 4 Minimally Conscious (MCS) 11 age- sex-matched controls were examined. Evoked responses obtained by 64 scalp electrodes, while delivering...
Onabotulintoxin A (BontA) is an efficacious preventive treatment for chronic migraine, though the specific mechanism of action still under discussion. The study aims: (1) To evaluate pain processing modifications in migraine patients (CM) single BontA administration pericranial muscles, by means CO2 Laser Evoked Potentials (LEPs) obtained stimulation skin over right frontal and trapezius injection sites hand dorsum, a double blind placebo controlled crossover design. (2) correlate main LEPs...
Background Transcutaneous external supraorbital nerve stimulation has emerged as a treatment option for primary headache disorders, though its action mechanism is still unclear. Study aim In this randomized, sham-controlled pilot study we aimed to test the effects of single transcutaneous session on pain perception and cortical responses induced by painful laser stimuli delivered right forehead hand in cohort migraine without aura patients healthy controls. Methods Seventeen 21 age-...
This study aimed to evaluate age-related changes in laser-evoked potential (LEP) features, including habituation, via trigeminal and hand stimulation a large group of healthy volunteers.We recorded the LEPs by right-hand 237 subjects right supraorbital zone 170 cases. The ranged age from 7 72 years were divided into six groups age.At level, N2 P2 latencies significantly shorter N2-P2 amplitude was larger 7-17 than other groups. responses evoked 7-40 range older subjects. N1 latency not...
Previous studies indicated changes of motor cortex excitability in fibromyalgia (FM) patients and the positive results transcranial stimulation techniques. The present study aimed to explore metabolism FM patients, resting state during slow fast finger tapping, using functional Near-Infrared Spectroscopy (fNIRS), an optical method which detects real time cortical tissue. We studied 24 healthy subjects. found a significant slowness speed compared controls. During movement conditions, areas...
Cognitive impairment (CI) is a common and disabling symptom of Multiple Sclerosis (MS) with negative impact on daily living. In this pilot study, we applied magnetoencephalography (MEG) high density (hd) electroencephalography (EEG) study to evaluate acoustic P300 features in cohort early MS. Sixteen MS patients (pwMS) 19 healthy controls (HCs) matched for age gender underwent an MEG-/(hd)-EEG-co-recording, using 306-channel Vectorview 64 scalp electrodes. CI was assessed Rao’s Brief...
The discovery of the prominent action Calcitonin Gene Related Peptide -CGRP- on trigeminal afferents and meningeal vessels, opened a new era in migraine treatment. However, how block nociceptive could act central mechanisms is still not clear. In this pilot study we aimed to test effect 3 months Galcanezumab (CGA) therapy occipital visual reactivity patients, using Steady State Visual Evoked Potentials-SSVEPs Functional Near Infrared Spectroscopy -fNIRS.Thirteen patients underwent clinical...
Belief and expectation are part of placebo effect. Migraine patients characterized by a dysfunctional modulation pain processing, though clear effect emerges in clinical trials. The aim the study was to evaluate visual verbal suggestion on subjective sensation cortical responses evoked CO2 painful laser stimuli migraine without aura vs healthy controls. Twenty-six were recorded during inter-ictal phase compared 26 sex age-matched right hand supraorbital zone stimulated not conditioned task,...
Scientific literature does not offer sufficient data on electroencephalography (EEG) functional connectivity and its correlations with clinical cognitive features in premanifest manifest HD. This study tries to identify abnormal EEG patterns of connectivity, conditions "brain resting state" motor decline variable Huntington's disease (HD), phase, looking for a reliable marker measuring progression. was an observational cross-sectional study; 105 subjects age ≥18 years submitted HD genetic...
A recent multicenter trial provided Class I evidence that for patients with an episodic migraine, non-invasive vagus nerve stimulation (nVNS) significantly increases the probability of having mild pain or being pain-free 2 h post-stimulation. Here we aimed to investigate potential effect nVNS in modulation spontaneous and related bioelectrical activity a subgroup migraine enrolled PRESTO by using resting-state electroencephalography trigeminal laser-evoked potentials (LEPs). LEPs were...