A5102896742- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Spine and Intervertebral Disc Pathology
- Traumatic Brain Injury and Neurovascular Disturbances
- Spinal Fractures and Fixation Techniques
- Radiomics and Machine Learning in Medical Imaging
- Head and Neck Surgical Oncology
- Neurosurgical Procedures and Complications
- Spacecraft and Cryogenic Technologies
- Neonatal and fetal brain pathology
- Cerebrovascular and Carotid Artery Diseases
- Moyamoya disease diagnosis and treatment
- Brain Metastases and Treatment
- Geophysics and Gravity Measurements
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Nanoplatforms for cancer theranostics
- Musculoskeletal pain and rehabilitation
- MRI in cancer diagnosis
- Neurofibromatosis and Schwannoma Cases
- Neonatal Respiratory Health Research
- Spinal Dysraphism and Malformations
Agostino Gemelli University Polyclinic
2009-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
European Space Research Institute
2021-2024
Università Cattolica del Sacro Cuore
2012-2022
Catholic University of America
2004-2020
University of Udine
2020
Sapienza University of Rome
2012-2014
University of Chieti-Pescara
1978-2008
University of Milan
2002
Candiolo Cancer Institute
2002
Safe and efficient genetic modification of liver cells could enable new therapies for a variety hepatic systemic diseases. Lentiviral vectors are promising tools in vivo gene delivery. Previous data suggested that recruitment into the cell cycle was required transduction hepatocytes vivo. We developed an improved vector design enhanced nuclear translocation target significantly transfer performance. Using panel internal promoters, we showed rat were transduced ex to high frequency without...
The survival benefit in maximizing resection glioblastomas (GBMs) has been demonstrated by numerous studies. true limit of infiltration GBMs an overwhelming obstacle, and several technological advances have introduced to improve the identification residual tumors.To evaluate whether integration 5-aminolevulinic acid (5-ALA) with microbubble contrast-enhanced ultrasound (CEUS) improves tumor impact on extent (EOR), overall (OS), progression-free (PFS).A total 230 GBM procedures were...
Abstract Purpose: It has been hypothesized that brain tumors are derived from stem cell or transiently dividing precursor transformation. Furthermore, c-Jun NH2-terminal kinases (JNKs) have involved in gliomagenesis. This study analyzes marker nestin and JNK expression glioblastoma multiforme (GBM) peritumor tissue assesses their possible prognostic implications. Experimental Design: Nestin both total (tJNK) phosphorylated (pJNK) was investigated by immunohistochemistry 20 GBMs. Samples were...
The gene expression pattern of glioblastoma (GBM) is well documented but the profile brain adjacent to tumor not yet analysed. This may help understand oncogenic pathway GBM development. We have established genome-wide profiles samples isolated from mass, white matter (apparently free cells), and controls by using Affymetrix HG-U133 arrays. Array-CGH (aCGH) was also performed detect genomic alterations. Among genes dysregulated in peritumoral matter, 15 were over-expressed, while 42...
OBJECTIVE Intraoperative MRI (iMRI) is the gold-standard technique for intraoperative evaluation of extent resection in brain tumor surgery. Unfortunately, it currently available at only a few neurosurgical centers. A commercially software, Virtual iMRI Cranial, provides an elastic fusion between preoperative and CT (iCT). The aim this study was to evaluate accuracy software determining presence residual tumor. METHODS performed patients who underwent iCT after intracranial resection....
Background/Objectives: Lumbar disc herniation, a complex challenge in spinal health, significantly impacts individuals across diverse age groups. This article delves into the intricacies of this condition, emphasising pivotal role anatomical considerations its understanding and management. Additionally, lumbar discectomy might be considered an “easy” surgery; nevertheless, it carries significant risks. The aim study was to present groundbreaking “three-step approach” with some insight...
Background/Objectives: Degenerative lumbar spine conditions are a major cause of disability, particularly in elderly patients or those with comorbidities. Surgical treatment often combines decompression and stabilization to address pain instability. Pedicle screws the gold standard for but pose challenges compromised bone quality. Interspinous devices have emerged as less invasive alternative, comparative studies limited. This study aimed compare clinical surgical outcomes using pedicle...
Background/Objectives: Lumbar disk herniation (LDH) significantly affects quality of life due to lower back and radiating leg pain. Surgical intervention, such as discectomy, is effective for symptom relief when conservative measures fail; however, psychological factors like anxiety, depression, maladaptive coping strategies may negatively impact surgical outcomes. This study aims assess the role preoperative evaluations in predicting postoperative recovery identify key functional predictors...
Background/Objectives: Degenerative lumbar spine conditions are a major cause of disability, particularly in elderly patients or those with comorbidities. Surgical treatment often combines decompression and stabilization to address pain instability. Pedicle screws the gold standard for but pose challenges compromised bone quality. Interspinous devices have emerged as less invasive alternative, comparative studies limited. This study aimed compare clinical surgical outcomes using pedicle...
Abstract Background Inferior Fronto-Occipital Fascicle (IFOF) is a multitasking connection bundle essential for communication and high level mentalization. The aim of the present study was to quantitatively assess its radiological-anatomical-morphometric modifications according different brain tumor histotype. Methods A retrospective multicentric Italian conducted. IFOF reconstructions were calculated both hemispheres each patient diagnosed with Glioblastoma (GBM), Low Grade Glioma (LGG),...
OBJECTIVE Providing new tools to improve surgical planning is considered a main goal in meningioma treatment. In this context, two factors are crucial determining operating strategy: meningioma-brain interface and consistency. The use of intraoperative ultrasound (ioUS) elastosonography, real-time imaging technique, has been introduced general surgery evaluate similar features other pathological settings such as thyroid prostate cancer. aim the present study was ioUS elastosonography...
The glioblastoma microenvironment plays a substantial role in glioma biology. However, few studies have investigated its spatial heterogeneity. Exploiting 5-ALA Fluorescence Guided Surgery (FGS), we were able to distinguish between the tumor core (ALA+), infiltrating area (ALA-PALE) and healthy tissue (ALA−) of glioblastoma, based on level accumulated fluorescence. aim this study was investigate properties microenvironments associated with these regions. For purpose, isolated...