A5025984050- Glioma Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Brain Metastases and Treatment
- Breast Cancer Treatment Studies
- Radiation Therapy and Dosimetry
- Management of metastatic bone disease
- Neuroblastoma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer Treatment and Pharmacology
- Sarcoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Meningioma and schwannoma management
- Advances in Oncology and Radiotherapy
- Lung Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Ocular Oncology and Treatments
- Lymphoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Boron Compounds in Chemistry
- Microtubule and mitosis dynamics
- Radiation Effects and Dosimetry
- Brain Tumor Detection and Classification
- CNS Lymphoma Diagnosis and Treatment
- Surgical site infection prevention
- Tumors and Oncological Cases
Fondazione IRCCS Istituto Nazionale dei Tumori
2015-2022
Università Cattolica del Sacro Cuore
2011-2018
Fondazione IRCCS Istituto Neurologico Carlo Besta
2016
Defence Materiel Administration
2015
Agostino Gemelli University Polyclinic
2010
This prospective study stratified patients by surgical resection (complete = NED vs incomplete ED) and centrally reviewed histology (World Health Organization [WHO] grade II III). WHO II/NED received focal radiotherapy (RT) up to 59.4 Gy with 1.8 Gy/day. Grade III/NED 4 courses of VEC (vincristine, etoposide, cyclophosphamide) after RT. ED 1–4 courses, second-look surgery, followed an 8-Gy boost in 2 fractions on still measurable residue. children aged 1–3 years tumors could receive 6 alone....
We explored the feasibility of concurrent palliative chemotherapy and low-dose fractionated radiotherapy (LD-FRT) in glioblastoma multiforme (GBM). Patients with recurrent/progressive GBM at least 3 months after end primary received 0.3 Gy twice daily cisplatin fotemustine if progressing on temozolomide, or 0.4 temozolomide recurrent 4-6 later (retreatment group). Newly diagnosed gross residual mass 30 concomitant adjuvant from second cycle (naive group) for 2-4 cycles. Twenty-six patients...
Age is an unfavorable prognostic factor in glioblastoma multiforme (GBM). To assess the possibility and advantage of radiotherapy (RT) plus concomitant/sequential temozolomide (TMZ) patients over 65 years with GBM, we analyzed 4 prospective trials terms compliance outcomes.Elderly histologically proven included phase II studies a Karnofsky Performance Status (KPS) >70 Charlson Comorbidity Index (CCI) <3, were selected for these analyses. Patients treated by 3D-conformal RT (60 Gy),...
Diffuse midline gliomas (DMGs) originate in the thalamus, brainstem, cerebellum and spine. This entity includes tumors that infiltrate pons, called diffuse intrinsic pontine (DIPGs), with a rapid onset devastating neurological symptoms. Since surgical removal DIPGs is not feasible, purpose of this study was to profile circulating miRNA expression DIPG patients an effort identify non-invasive prognostic signature clinical impact. Using high-throughput platform, profiled serum samples...
Chest wall reconstruction after surgical resection for malignancies in children is a challenge surgeons because of growth-related complications. The aim this study to analyze the treatment and outcomes 30 pediatric adolescent patients treated at Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy, over 30-year period.Pediatric undergoing chest were retrospectively reviewed selected malignant primary tumor. Endpoints survival, recurrences, long-term results. We also reported use...
This study reports the treatment feasibility and efficacy of a novel multiagent intensive program for young patients with desmoplastic small round cell tumor. series includes three should be seen as first suggestion integration dose density maintenance chemotherapy concept. The IrIVA regimen (irinotecan, ifosfamide, vincristine, actinomycin-D) is added-used at short interval between administrations-at more classic ifosfamide-based regimens. vinorelbine low-dose oral cyclophosphamide therapy...
BackgroundTo evaluate the efficacy of preoperative low dose fractionated radiotherapy (LD-FRT) and chemotherapy in breast cancer.Materials methodsPatients with stage IIA–IIIA cancer, received LD-FRT (0.40 Gy bid, on day 1 2, for 6 cycles) to primary tumor volume concurrent non-pegylated liposomal anthracycline docetaxel. Pathological response was assessed by Mandard Tumor Regression Grade (TRG). We evaluated pathological major rate (PMRR) as TRG1 TRG2. The expected outcome a PMRR 60%....
To evaluate the dosimetric coverage of axillary levels I, II, and III obtained with standard whole breast irradiation in 1 to 2 positive sentinel lymph nodes (SLNs) patients not submitted dissection (ALND), compare areas 3D conformal radiation therapy, intensity-modulated radiotherapy (IMRT), volumetric modulated arc therapy (VMAT).Patients SLNs undergoing breast-conserving without ALND, were included analysis. For each patient, 3 treatment plans performed: a conventional tangential plan,...
Purpose Breast cancer survivors have a high risk of cardiac death as consequence heart irradiation during left breast tangential radiotherapy (RT). This study compares the dose delivered by standard 3D conformal RT (CRT) to that prospective-gating (PGRT) or 5-field intensity-modulated (IMRT). Methods Patients with early cancer, referred for adjuvant our institution, were enrolled in this study. For each patient, 2 simulation computed tomography scans acquired: first free breathing, and...
Abstract A standardized multidisciplinary step‐by‐step approach to improve the compliance of young (or difficult) children having undergo radiotherapy was described and applied. The procedure is called SIESTA, which stands for show‐imagination‐evaluation‐support‐treatment‐anesthesia. Preliminary assessments suggest that SIESTA effective: rate patients (≤6 years) requiring anesthesia decreased from 27% (14/52 cases) in 2011‐2012 (before adopted) 13% (6/46) 2018.
Due to the rarity of nongerminomatous germ cell tumors (NGGCT) with non-standard treatment as yet, we report retrospectively our 30 year experience chemotherapy followed by craniospinal irradiation (CSI), plus a boost whole ventricular (WVI)/tumor bed (TB), tailored pre-radiation response. Between 1988 and 2016, 28 patients received four cycles PEB (cisplatin/etoposide/bleomycin), then CSI, two further cycles. and1994, CSI was 25.5 Gy for in complete remission (CR), if partial (PR) or...
Clinical data of ri-SGCs patients treated between 2015 and 2019 at a tertiary cancer center national hadron therapy facility were reviewed. Latent time (LT) from first RT to diagnosis, overall (OS), disease-free survival (DFS) assessed. Thirteen developed 14 (one patient had 2 synchronous ri-SCGs), after median LT 23 years (range 16–34). Parotid was the primary site in 8 cases (57%) salivary duct carcinoma most frequent histotype (29%). Nine (69%) underwent surgery (Sx). Among them, 4 (31%)...
Purpose To study a robust and reproducible procedure to investigate relation between focal brain radiotherapy (RT) low doses, neurocognitive impairment late White Matter Gray alterations, as shown by Diffusion Tensor Imaging (DTI), in children. Methods materials Forty-five patients (23 males 22 females, median age at RT 6.2 years, evaluations 11.1 years) who had received for tumors were recruited DTI exams tests. Patients’ brains parceled 116 regions of interest (ROIs) using an available...
After breast conservative surgery (BCS) and whole-breast radiotherapy (WBRT), the use of boost irradiation is recommended especially in patients at high risk. However, standard technique definition volume have not been well defined.We retrospectively compared an anticipated pre-operative photon on tumour, administered with low-dose fractionated radiotherapy, neoadjuvant chemotherapy two different sequential techniques, after BCS adjuvant WBRT: (1) a beam (2) electron tumour bed same...
Purpose: To analyze toxicity and outcome predictors in Ewing sarcoma patients with lung metastases treated busulfan melphalan (BU-MEL) followed by whole-lung irradiation (WLI). Methods: This retrospective study included 68 metastatic Sarcoma who underwent WLI after BU-MEL autologous stem cell transplantation, as part of two prospective consecutive treatment protocols. 12 Gy for <14 years old 15 ≥14 were applied at least eight weeks BU-MEL. Toxicity, overall survival (OS), event-free (EFS)...