A5009534920- Sarcoma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Adolescent and Pediatric Healthcare
- Family Support in Illness
- Bacterial Identification and Susceptibility Testing
- Neuroblastoma Research and Treatments
- Neutropenia and Cancer Infections
- Acute Myeloid Leukemia Research
- COVID-19 and healthcare impacts
- Chronic Lymphocytic Leukemia Research
- Hemoglobinopathies and Related Disorders
- Empathy and Medical Education
- Neurofibromatosis and Schwannoma Cases
- Testicular diseases and treatments
- Glioma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Lymphoma Diagnosis and Treatment
- COVID-19 and Mental Health
- Acute Ischemic Stroke Management
- Palliative Care and End-of-Life Issues
- Cardiac tumors and thrombi
- Immunodeficiency and Autoimmune Disorders
- Blood disorders and treatments
- Antibiotics Pharmacokinetics and Efficacy
- Iron Metabolism and Disorders
Azienda Ospedaliera di Padova
2021-2025
University of Padua
2009-2024
Abstract Background Guidelines about febrile neutropenia in paediatric patients are not homogeneous; the best empiric treatment of this condition should be driven by local epidemiology. The Weighted-Incidence Syndromic Combination Antibiogram (WISCA) addresses need for disease-specific susceptibility evidence that could guide antibiotic prescriptions based on outcome estimates regimens obtained as a weighted average pathogen susceptibilities. This study developed WISCA model to inform...
ABSTRACT Background Several studies have shown that the intensity of treatment in Ewing sarcoma has an impact on outcome. The present trial tested non‐inferiority intensive, shorter, induction chemotherapy (25 weeks total time) compared to standard (37 weeks) non‐metastatic (ES) at onset. Procedure This national, multicenter, parallel, randomized, controlled, open‐label, non‐inferiority, phase III was conducted 14 specialized hospitals Italy. Patients aged 2‐40 years with newly diagnosed...
Malignant peripheral nerve sheath tumor (MPNST) is one of the most common nonrhabdomyosarcoma soft tissue sarcomas encountered in pediatric age, and it generally characterized by poor outcome, particularly for relapsing patients.This study considered 73 patients <21 years age with MPNST observed among 120 enrolled Italian protocols from 1979 to 2004. With aim possibly establishing a risk-adapted stratification, patients' outcome was examined using univariate multivariate analysis based on...
Worldwide, the coronavirus 19 disease pandemic caused a worse chance of timely diagnosis for cancer patients. We conducted retrospective analysis new diagnoses registered in national pediatric oncology database, comparing first lockdown period (March-May 2020) with same 2015-2019. The total number cases (0-19 years) dropped by 20.8% (from 441 between 2015 and 2019 to 349 2020). A major reduction was observed adolescents (15-19 (-32.9%) solid tumors (-56.4%, p = 0.03). Our data suggest that...
Introduction: From 2002 to 2011, the Italian Soft Tissue Sarcoma Committee explored a combination of topotecan and carboplatin as second-line strategy for children with resistant or relapsing rhabdomyosarcoma. Methods: Patients received two blocks 2 mg/m on days 1, 2, 3, 250 4 5, followed by alternating topotecan–cyclophosphamide carboplatin–etoposide total six courses 3-week intervals. Tumor response was assessed after cycles, local control implemented when feasible. Results: A 38 patients...
Stroke is a serious complication of sickle cell disease (SCD) in children. Transcranic Doppler (TCD) well-established predictor future cerebrovascular symptoms: blood flow velocity >200 cm/sec the Middle Cerebral Artery (MCA) correlates with high risk stroke cohorts African-american HbS/HbS patients. In North-East Italy recent increase SCD patients mainly due to immigration from Africa. A comprehensive care program for children was established our Center since 2004, but wide and routine...
Abstract Background Rhabdomyosarcoma (RMS) is a highly malignant tumor typically affecting children and adolescents. Central nervous system (CNS) dissemination rare in RMS patients, but seems to have particularly negative impact. The aim of this study was analyze treatment outcome patients with evidence CNS disease who were registered the protocols coordinated by Italian Soft Tissue Sarcoma Committee from March 1979 December 2016. Methods We analyzed 39 disease. Depending on when their...
We describe three children who developed an osteosarcoma after receiving treatment for acute lymphoblastic leukemia, which included allogeneic bone marrow transplant (BMT). discuss the therapeutic options. None of patients responded to conventional chemotherapy, but one patient given regorafenib showed a temporary response. conclude that BMT has aggressive course and it is worth further investigating multikinase inhibitors in this setting.
Società Scientifiche Italiane Insieme per gli Adolescenti con Malattie Onco-ematologiche (SIAMO) is an Italian nationwide scheme that focuses on adolescent patients with cancer. Some of its activities include promoting dedicated local projects at the various oncology centers all over country and organizing events to improve awareness regarding cancer in adolescence. It these aims mind it organized Winners' Cup, a football tournament between adolescents who had (or had) pediatric cancers....
Objective: To describe the implementation of a multi-step antimicrobial stewardship program in haemato-oncology and stem cell transplantation unit. Methods: Pre-post quasi-experimental study with two interrupted time-series analyses, conducted between 01/01/2019 31/12/2022 Paediatric Haemato-Oncology Unit Padua Hospital. The interventions were: (1) 02/2020: dissemination febrile neutropenia clinical pathways, (2) April 2021: provision pathways via customized App (Firstline.org) twice-a-week...
Adolescents and young adults (AYA) with oncohematological diseases could have important psychosocial difficulties that be worsened by the effects of COVID19 pandemic. At this developmental stage, it is also to assess use social networks (SNs). This study aims investigate type network consequences period. These patients are compared matched healthy peers.After informant consent signature, adolescents completed a series self-report questionnaires on SNs, communication preferences, anxiety...
Purpose: To analyze toxicity and outcome predictors in Ewing sarcoma patients with lung metastases treated busulfan melphalan (BU-MEL) followed by whole-lung irradiation (WLI). Methods: This retrospective study included 68 metastatic Sarcoma who underwent WLI after BU-MEL autologous stem cell transplantation, as part of two prospective consecutive treatment protocols. 12 Gy for <14 years old 15 ≥14 were applied at least eight weeks BU-MEL. Toxicity, overall survival (OS), event-free (EFS)...