A5057620274- Pharmaceutical Practices and Patient Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical studies and practices
- SARS-CoV-2 and COVID-19 Research
- Medication Adherence and Compliance
- Pharmaceutical Economics and Policy
- Patient Safety and Medication Errors
- COVID-19 Clinical Research Studies
- Pharmacovigilance and Adverse Drug Reactions
- Biomedical Ethics and Regulation
- Antibiotics Pharmacokinetics and Efficacy
- Pharmacy and Medical Practices
- Hepatitis C virus research
- Biosimilars and Bioanalytical Methods
- Cardiac, Anesthesia and Surgical Outcomes
- Long-Term Effects of COVID-19
- Antibiotic Use and Resistance
- Ethics in Clinical Research
- Cardiac pacing and defibrillation studies
- Respiratory viral infections research
- Antiplatelet Therapy and Cardiovascular Diseases
- Healthcare Systems and Technology
- Acute Myocardial Infarction Research
- Hepatitis B Virus Studies
- Cystic Fibrosis Research Advances
University of Padua
2022-2025
Azienda Ospedaliera di Padova
2023-2025
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2014-2020
Bar-Ilan University
2019
Hong Kong Polytechnic University
2019
Metacomp Technologies (United States)
2019
Tel Aviv University
2019
École Polytechnique Fédérale de Lausanne
2019
University of California, Los Angeles
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2019
Molnupiravir (MOL) and nirmatrelvir/ritonavir (NIR) were recently approved for the early treatment of COVID-19, but real-life data on tolerability, safety, adverse events (AEs) are still scarce.We conducted a retrospective cohort study including all patients who prescribed MOL NIR at Infectious Diseases Unit Padua University Hospital, between January May 2022. Demographic, clinical, safety variables recorded.We included 909 patients, 48.3% males 95.2% vaccinated against SARS-CoV-2. The...
A large increase in multi-drug-resistant Acinetobacter baumannii, especially carbapenem-resistant strains, occurred during the first two years of COVID-19 pandemic, posing important challenges its treatment. Cefiderocol appeared to be a good option for treatment Carbapenem-resistant baumannii (CR-Ab), but date, guidelines and evidence available are conflicting.We retrospectively included group patients with CR-Ab infections (treated colistin- or cefiderocol-based regimens) at Padua...
Background/Objectives: Off-label drug use is prevalent in pediatric care, particularly palliative care (PPC), due to the scarcity of pediatric-specific formulations and clinical trials. Differences perception between healthcare professionals regarding off-label prescriptions underscore complexity this practice highlight need for improved collaboration optimize therapeutic outcomes. Methods: A cross-sectional observational study was conducted from August October 2021 at PPC center University...
The hSNF5 chromatin-remodeling factor is a tumor suppressor that inactivated in malignant rhabdoid tumors (MRTs). A number of studies have shown re-expression blocks MRT cell proliferation. However, the pathway through which acts remains unknown. To address this question, we generated MRT-derived lines restoration expression leads to an accumulation G0/G1, induces cellular senescence and increased apoptosis. Following expression, observed transcriptional activation p16INK4a but not p14ARF,...
ABSTRACT Polycomb group (PcG) proteins function through cis -acting DNA elements called PcG response (PREs) to stably silence developmental regulators, including the homeotic genes. However, mechanism by which they are targeted PREs remains largely unclear. Pleiohomeotic (PHO) is a sequence-specific DNA-binding protein and therefore may tether other DNA. Here, we show that PHO can directly bind (PC)-containing complex as well Brahma (BRM) chromatin-remodeling complex. contacts BRM its zinc...
To determine which factors affect compliance with sulfonylureas in a population served by health maintenance organization Southern California.Retrospective analysis of pharmacy records and healthcare utilization data for two years (April 1993-March 1995), survey mailed to patients. Patients treated were selected on the basis their prescription profile. Compliance was measured from as proportion days patient possession prescribed medications. Patient modeled function four clusters...
The European Medicine Agency extended the use of Comirnaty, Spikevax, and Nuvaxovid in paediatrics; thus, these vaccines require additional real-world safety evidence. Herein, we aimed to monitor COVID-19 through Covid-19 Vaccine Monitor (CVM) EudraVigilance surveillance systems published pivotal clinical trials.In a prospective cohort vaccinees aged between 5 17 years, measured frequency commonly reported (local/systemic solicited) serious adverse drug events (ADRs) following first second...
Abstract Purpose Preliminary data suggested that bone mineral density (BMD) in transgender adults before initiating gender-affirming hormone therapy (GAHT) is lower when compared to cisgender controls. In this study, we analyzed metabolism a sample of GAHT, and its possible correlation with biochemical profile, body composition lifestyle habits (i.e., tobacco smoke physical activity). Methods Medical data, smoking habits, phospho-calcic hormonal blood tests densitometric parameters were...
Background/Objectives: Off-label drug use is prevalent in pediatric care, particularly palliative care (PPC), due to the scarcity of pediatric-specific formulations and clinical trials. Differences perception between healthcare professionals regarding off-label prescriptions underscore complexity this practice highlight need for improved collaboration optimize therapeutic outcomes. Methods: A cross-sectional observational study was conducted from August October 2021 at PPC center University...
BackgroundPatients admitted to the Paediatric Intensive Care Unit (PICU) constitute a high-risk group with heightened likelihood of receiving inappropriate antimicrobial prescriptions. This study describes an Antimicrobial Stewardship Programme (ASP) in PICU tertiary hospital Italy.MethodA pre-post quasi experimental was conducted between 01/01/2019 and 31/12/2022 Department for Women's Children's Health, University Hospital Padua. The ASP intervention started February 2021 by...
Remdesivir (RDV) and nirmatrelvir/ritonavir (NRM/RTV) are two antiviral agents for treating outpatient adults with mild to moderate symptomatic COVID-19 at high risk of developing a severe disease. The review objectives compare the efficacy safety these antivirals based on published RCT real-world data, evaluate costs from healthcare perspective. This study provides network meta-analysis RDV NRM/RTV early treatment COVID-19. outcomes analysed were hospitalisation any cause serious adverse...
Background/Objectives: Clinical pharmacy plays a crucial role in optimizing medication use, particularly pediatric settings where drug therapy can be complex and understudied. This study aims to assess the impact of clinical pharmacists Pediatric Neurology Neurophysiology Unit, focusing on physician acceptance pharmacist suggestions types advice most frequently followed. Methods: A retrospective observational was conducted over 13 weeks, involving three phases: best possible history...
Data about risk factors for treatment failure (TF) to dalbavancin are lacking. Our aim was investigate the clinical, microbiological and laboratory predictors of TF in both on- off-label treatments. We included all patients who received at least one dose our center from January 2018 June 2024 with available data on follow-up, collecting clinical parameters. defined as need readmission, emergency department access, or death within 90 days after treatment. Factors correlating mortality rate...
Since the beginning of Coronavirus Disease 2019 (COVID-19) pandemic, many drugs have been purposed for treatment severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Remdesivir emerged as an encouraging antiviral drug patients with documented COVID-19-related pneumonia. Although several studies about remdesivir effectiveness exist, no study investigated effect combination vaccination status. The aim this was to assess whether administration could show some differences in terms...
Children with medical complexity (CMC) often require multiple medications, leading to polypharmacy, which seems be linked adverse effects, administration errors, and increased caregiver burden. This study aimed describe the prevalence of medication burden, off-label drug use, associated costs.
Background/Objectives: Clinical pharmacy plays a crucial role in optimizing medication use, particularly pediatric settings where drug therapy can be complex and understudied. This study aims to assess the impact of clinical pharmacists Pediatric Neurology Neurophysiology Unit Padova University Hospital, focusing on physician acceptance pharmacist suggestions types advice most frequently followed. Methods: A retrospective observational was conducted over 13 weeks describe implementation...