In the prevention of variceal rebleeding, it is already established that hemodynamic response to drug treatment (decrease in hepatic venous pressure gradient [HVPG] 12 mm Hg or by >20%) predictive clinical effectiveness. primary prophylaxis very few data are available. We assessed role beta–blockers plus nitrates predicting efficacy prophylaxis. A total 49 cirrhotic patients with varices at risk bleeding, without prior were investigated vein catheterization before and after 1 3 months...

Remodeling of the resistance arteries is a hallmark arterial hypertension and predicts cardiovascular events, but it was unknown whether could also predict blood pressure response to adrenalectomy patients with an aldosterone-producing adenoma. Therefore, we investigated outcome as function vascular remodeling in context preoperative features adenoma patients. At 2 referral centers for hypertension, prospectively measured media:lumen ratio small from fat tissue 50 consecutive treated...

In patients with cirrhosis, the clinical benefit of treatment human albumin for ascites is debated, and no data are available regarding refractory ascites. this study, in cirrhosis ascites, we assessed effect long-term administration on emergent hospitalization mortality.Seventy followed at Unit Internal Medicine Hepatology, University General Hospital Padova, Italy, were included into study. Forty-five non-randomly assigned to receive doses 20 g twice per week (n = 45), addition standard...

Background: Left ventricular systolic abnormalities have been reported in liver cirrhosis (LC). Diastolic function cirrhotics, on the contrary, does not seem to studied so far. Methods: was evaluated 42 cirrhotic patients and 16 controls by means of Doppler echocardiography. Results: Compared with controls, cirrhotics had increased left end-diastolic atrial volume, stroke late diastolic flow velocity (peak A) (71 ± 17 cm/sec versus 56 18; p < 0.01), time from onset mitral inflow early peak...

Studies of renal perfusion when kidney function tests are still normal could be useful to understand the pathophysiology functional impairment in cirrhosis; currently, this requires invasive methodology. Duplex Doppler ultrasonography allows noninvasive evaluation intrarenal arterial resistances. In 19 nonascitic and 35 ascitic cirrhotic patients with (normal serum creatinine urea levels) 17 controls, we measured pulsatility index (Pulsatility = [Peak systolic velocity-Minimum diastolic...

It is clearly established that β-blockers decrease the risk of a first variceal bleeding in cirrhosis. We have recently shown addition isosorbide mononitrate to nadolol decreases rate patients with cirrhosis and varices, compared alone, after median follow-up 30 months. not if long-term treatment combination continues be beneficial. Therefore, we assessed effect this on bleeding, complications, death. One hundred forty-six cirrhotic esophageal varices included previously published...

The association β-blockers plus isosorbide-5-mononitrate (I5M) has been proposed for the treatment of portal hypertension in patients with insufficient response to alone, according hemodynamic criteria. mechanism action these is not clearly defined. Fifteen cirrhosis and esophageal varices were evaluated by hepatic venous pressure gradient (HVPG) measurement duplex-Doppler ultrasonography before after 1 month nadolol. Nine who did exhibit a decrease HVPG 12 mm Hg or percent greater than 20%...

Information on changes in splanchnic hemodynamics after liver transplantation is incomplete. In particular, data long-term are lacking, and the relationship between arterial portal parameters still under debate. The effect of was analyzed with echo-Doppler 41 patients cirrhosis who were followed for up to 4 years. Doppler also evaluated 7 transplanted acute failure 35 controls. cirrhotics, blood velocity flow increased immediately (from 9.1 ± 3.7 cm/sec 38.3 14.6 from 808 479 mL/min 2,817...

The spleen plays a pivotal role in the pathogenesis and maintenance of portal hypertension. Few data exist about splenic hemodynamics evaluated by duplex sonography this condition. Twenty-six normal subjects, 207 patients with hypertension various causes, different splenoportal hemodynamic conditions, 31 liver transplantation were evaluated. In each patient resistive index (RI = peak systolic--end diastolic velocity/peak systolic velocity) pulsatility (PI velocity/mean measured. 17 cirrhotic...

This prospective study assessed the role of aminopyrine breath test in prognosis patients with cirrhosis, and evaluated whether provided useful information not included Pugh score. During a period 36 months, 125 biopsy proven liver cirrhosis were included, followed for up to 48 months (median 17 months). follow 43 died (20 failure). Survival was univariately related (p less than 0.02), score 0.01), presence ascites sex 0.05). Using Cox9s regression analysis, score, test, sex, independent...

Background:We investigated the effect of green tea extract (GTE) in arterial hypertension with high oxidative stress. Angiotensin (Ang) II induces endothelial dysfunction (ED) that is crucial for development atherosclerosis and hypertension.

In liver cirrhosis, oxidative stress plays a major role in promoting inflammation and fibrosis. Mitochondria dysregulation is responsible for excessive reactive oxygen species production. Therefore, an experimental model of we investigated the effect mitochondria-targeted antioxidant mitoquinone. Liver cirrhosis was induced Spraque-Dawley rats by common bile duct ligation (CBDL). Mitoquinone (10 mg·kg-1·day-1, oral gavage) or vehicle administered from 3rd to 28th day after CBDL, when animals...

The reticuloendothelial system plays an important role in the prevention of bacterial infection patients with cirrhosis. Few data are available, however, on its activity such patients. aim this study was to evaluate maximum removal capacity hepatic cirrhosis basis kinetics increasing amounts 99mTc millimicrospheres and verify value as a prognostic factor for death development spontaneous peritonitis. Common clinical biochemical parameters, Pugh score, capacity, aminopyrine metabolic...

Nadolol, a nonselective beta-blocker, has been shown to decrease portal pressure in patients with cirrhosis at the same degree as propranolol. No data are available, however, about its effect on rebleeding rate and mortality undergoing prevention of from esophageal varices. A prospective randomized clinical trial was performed who survived documented episode variceal hemorrhage. 12 received nadolol, placebo. Patients child's C grade, tense ascites, renal failure, contraindications or age >...

Large-conductance calcium-activated potassium channels (BK_Cas) are important regulators of arterial tone and represent a mediator the endogenous vasodilator carbon monoxide (CO). Because an up-regulation heme oxygenase (HO)/CO system has been associated with mesenteric vasodilatation cirrhosis, we analyzed interactions BK_Ca HO/CO in endothelium-dependent dilatation arteries ascitic cirrhotic rats. In pressurized (diameter, 170–350 μm) rats, evaluated effect inhibition...