A5029365962- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Neutropenia and Cancer Infections
- Long-Term Effects of COVID-19
- Cystic Fibrosis Research Advances
- COVID-19 and Mental Health
- Parvovirus B19 Infection Studies
- Urinary Tract Infections Management
- Nosocomial Infections in ICU
- COVID-19 Clinical Research Studies
- Polyomavirus and related diseases
- Neonatal and Maternal Infections
- Urinary Bladder and Prostate Research
- COVID-19 Impact on Reproduction
- Adolescent and Pediatric Healthcare
- Blood disorders and treatments
- Antifungal resistance and susceptibility
- Clinical Reasoning and Diagnostic Skills
- Pediatric Urology and Nephrology Studies
- Fungal Infections and Studies
- Childhood Cancer Survivors' Quality of Life
University of Padua
2022-2025
<h3>Importance</h3> Understanding the long-term immune response against SARS-CoV-2 infection in children is crucial to optimize vaccination strategies. Although it known that antibodies may persist adults 12 months after infection, data are limited pediatric population. <h3>Objective</h3> To examine anti–SARS-CoV-2 spike receptor-binding domain (S-RBD) IgG kinetics infection. <h3>Design, Setting, and Participants</h3> In this single-center, prospective cohort study, patients were enrolled...
Abstract Background Guidelines about febrile neutropenia in paediatric patients are not homogeneous; the best empiric treatment of this condition should be driven by local epidemiology. The Weighted-Incidence Syndromic Combination Antibiogram (WISCA) addresses need for disease-specific susceptibility evidence that could guide antibiotic prescriptions based on outcome estimates regimens obtained as a weighted average pathogen susceptibilities. This study developed WISCA model to inform...
The containment measures following COVID-19 pandemic drastically reduced airway infections, but they also limited the access of patients to healthcare services. We aimed assess antibiotic prescription patterns in Italian paediatric primary care setting before and after implementation. For this retrospective analysis, we used a population database, Pedianet, collecting data aged 0–14 years enrolled with family paediatricians (FP) from March 2019 2021. Antibiotic prescriptions were classified...
Abstract Background The prevention of invasive fungal infections (IFIs) is crucial for paediatric haemato-oncological patients. This study evaluates the clinical efficacy and side-effects posaconazole liposomal amphotericin B (L-AmB) as primary prophylaxis. Materials methods cohort included patients aged 3 months to 21 years who received or L-AmB (5 mg/kg twice weekly) prophylaxis from January 2017 March 2022 at Hemato-oncological Pediatric Unit, University Hospital Padua, Italy. Outcomes...
BackgroundPatients admitted to the Paediatric Intensive Care Unit (PICU) constitute a high-risk group with heightened likelihood of receiving inappropriate antimicrobial prescriptions. This study describes an Antimicrobial Stewardship Programme (ASP) in PICU tertiary hospital Italy.MethodA pre-post quasi experimental was conducted between 01/01/2019 and 31/12/2022 Department for Women's Children's Health, University Hospital Padua. The ASP intervention started February 2021 by...
Importance Point prevalence surveys (PPSs) are used globally to collect data on antibiotic prescriptions. However, the optimal frequency for collection ensure comprehensive understanding of use and target monitor stewardship interventions remains unknown. Objective To identify collecting among pediatric population through PPSs leveraging administrative data. Design, Setting, Participants This prognostic study a cross-sectional validation approach was conducted in outpatient inpatient...
Acute myocarditis has risen among paediatric patients in Italy, with 65 clinically suspected cases reported by 12 centres 2024, 32 linked to parvovirus B19 (B19V) infection. In 11 cases, B19V was not ruled out despite a concurrent European outbreak. Twenty-nine children required intensive care; eight fatalities occurred. While effective for both severe infection and myocarditis, intravenous immunoglobulins were given only one-third of cases. These findings highlight the need timely...
COVID-19 features changed with the Omicron variant of SARS-CoV-2 in adults. This study aims to describe symptoms children and adolescents during Parental, Delta, eras.A single-centre, prospective observational was conducted on individuals aged 0-20 years attending University Hospital Padua (Italy) from April 2020 December 2022. cases were defined by positive molecular detection and/or serology; patient/family virological positivity considered determine infection onset. Variables summarized...
Abstract Background Antibiotics are the most prescribed drugs for children worldwide, but overuse and misuse have led to an increase in antibiotic resistance. Antimicrobial stewardship programmes (ASPs) proven feasible reducing inappropriate antimicrobial use. The study aimed at evaluating impact sustainability of ASP with multiple interventions over 8 years. Methods This quasi-experimental was conducted between 2014 2022 paediatric acute care unit Padua University Hospital. Demographic...
(1) Background: SARS-CoV-2 infection is notably mild in children, though comorbidities may increase the risk of hospitalization and represent a for increased disease severity. There an urgent need targeted therapies with acceptable efficacy safety profile. To date, most medicines COVID-19-specific treatment are prescribed off-label children due to lack clinical trials consequent evidence this population. (2) Methods: This was retrospective, observational study investigating treatments...
We report the safe and effective use of oral linezolid for treatment Bacillus cereus sepsis in an extremely preterm neonate, previously fed with human donor milk, which a Brevibacillus sp. was eventually found. Due to several predisposing factors, premature, very low birth weight newborns are vulnerable invasive infections by environmental pathogens. After vancomycin microbiologic failure (despite adequate blood concentrations clinical response), chosen its optimal enteral absorption...
SARS-CoV-2 infection may impair behavior and mental health; we explored the psychological impact on parents children who experienced COVID-19 within their families. A cross-sectional web-based survey was conducted families attending Follow-up Clinic at Department for Women’s Children’s Health, Padua (Italy). From April 2020 to August 2021, 75 surveys were collected from 66 (97 129 children); almost 70% of participants had COVID-19, mostly asymptomatic/mildly symptomatic, median time...
Abstract Aim Children have largely been unaffected by severe COVID‐19 compared to adults, but data suggest that they may experienced new conditions after developing the disease. We outcomes in children who had and healthy controls. Methods A retrospective nested cohort study assessed incidence rate of new‐onset aged 0–14 years. Data were retrieved from an Italian paediatric primary care database linked Veneto Region registries. Exposed with a positive nasopharyngeal swab matched 1:1...
Urinary tract infections (UTIs) are the most common bacterial in children. The high variability pathogen susceptibility rates leads to lack of clear guidelines for empiric and targeted therapies. In this view, local microbiological surveillance locally adapted stewardship interventions need be implemented.
Skin and soft-tissue infections (SSTIs) are common infectious syndromes in children. Overusing broad-spectrum antibiotics has contributed to rising antibiotic resistance, complicating treatment outcomes. To address this issue, antimicrobial stewardship programs (ASPs) have been implemented optimize use. This study evaluated the impact of a multifaceted ASP on prescribing practices for SSTIs pediatric acute care setting over eight years.
Objective: To describe the implementation of a multi-step antimicrobial stewardship program in haemato-oncology and stem cell transplantation unit. Methods: Pre-post quasi-experimental study with two interrupted time-series analyses, conducted between 01/01/2019 31/12/2022 Paediatric Haemato-Oncology Unit Padua Hospital. The interventions were: (1) 02/2020: dissemination febrile neutropenia clinical pathways, (2) April 2021: provision pathways via customized App (Firstline.org) twice-a-week...
Antimicrobial stewardship programs (ASPs) and diagnostic (DSPs) are es-sential strategies for effectively managing infectious diseases tackling antimicrobial resistance (AMR). This narrative review highlights the necessity of a multidisciplinary approach, advocating involvement diverse healthcare professionals to support comprehensive practices in pediatric care. Emphasizing importance setting-specific interventions across inpatient, outpatient, emergency contexts, calls enhanced education...
Background: The omicron variant has spread globally at unprecedented speed due to a combination of epidemiological and virological factors that still need be fully unraveled. Although boosting immunity in vaccinated populations proven increase the antibody recognition for this variant, we ignore impact intervention on protection from infection disease.Methods: Relying live virus neutralization assay commercial chemiluminescence immunoassay targeting antibodies against receptor binding domain...
Parenteral artesunate (AS) is the WHO first-line treatment recommended in adults and children for severe malaria. Post-artesunate delayed haemolysis (PADH) an uncommon adverse reaction to AS with a mechanism that not fully understood, occurring children. Neutropenia another possible finding after treatment, albeit rare. We present case of child who experienced both effects imported Falciparum malaria very high parasitaemia. In addition, thirty-five paediatric cases PADH, five anaemia without...