A5007497275- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Infant Nutrition and Health
- Ultrasound in Clinical Applications
- Respiratory Support and Mechanisms
- Infant Development and Preterm Care
- Airway Management and Intubation Techniques
- Neuroscience of respiration and sleep
- Cardiovascular Conditions and Treatments
- Preterm Birth and Chorioamnionitis
- Antimicrobial Resistance in Staphylococcus
- Respiratory viral infections research
- Neonatal and fetal brain pathology
- Congenital Anomalies and Fetal Surgery
- Congenital Heart Disease Studies
- Birth, Development, and Health
- Tracheal and airway disorders
- Clinical Nutrition and Gastroenterology
- Phonocardiography and Auscultation Techniques
- Diabetes Management and Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Intestinal Malrotation and Obstruction Disorders
- Thermal Regulation in Medicine
- Pregnancy and preeclampsia studies
- Inhalation and Respiratory Drug Delivery
University of Padua
2015-2025
Città della Speranza Foundation
2018-2024
Santa Maria Nuova Hospital
2023
Alder Hey Children's Hospital
2021
University of Liverpool
2021
Nottingham University Hospitals NHS Trust
2021
Queen's Medical Centre
2021
Liverpool Women's Hospital
2021
Importance Surfactant administration may be needed in late preterm through full-term neonates, but the pathophysiology of their respiratory failure can different from that early neonates. The lung ultrasonography score (LUS) is accurate to guide surfactant replacement our knowledge, it has not yet been studied neonatal population. Objective To assess whether LUS equally predict need neonates as Design, Setting, and Participants This prospective, international, multicenter diagnostic study...
Early therapeutic effect of intratracheally (IT)-administered extracellular vesicles secreted by mesenchymal stem cells (MSC-EVs) has been demonstrated in a rat model bronchopulmonary dysplasia (BPD) involving hyperoxia exposure the first 2 postnatal weeks. The aim this study was to evaluate protective effects IT-administered MSC-EVs long term. EVs were produced from MSCs following GMP standards. At birth, rats distributed three groups: (a) animals raised ambient air for 6 weeks (n = 10);...
ABSTRACT Introduction Lung ultrasound score (LUS) is used to predict the need for surfactant in preterm neonates. Its performance lower neonates with a gestational age (GA) ≥ 34 weeks. We developed score, thoracic (TUS), overcome shortcomings of LUS. Objectives To assess feasibility and diagnostic accuracy TUS evaluate oxygenation administration, compared Materials Methods This was prospective, multicenter, observational study. Preterm noninvasive ventilation GA between 24 + 0 36 6 weeks...
Abstract Objective Current international guidelines on neonatal respiratory distress syndrome (RDS) recommend continuous positive airway pressure (CPAP) stabilization as primary treatment. Some surfactant replacement for babies requiring FiO 2 > 0.3 regardless of gestational age (GA). We explore the accuracy alternative inspired oxygen fraction (FiO ) thresholds early predictors in stratified by GA. Study Design Pragmatic, observational study 12 Italian and Spanish intensive care units....
<b><i>Introduction:</i></b> Early targeted surfactant therapy for preterm infants is recommended but the best criteria to personalize treatment are unclear. We validate a previously published multivariate prognostic model based on gestational age (GA), lung ultrasound score (LUS), and oxygen saturation inspire fraction ratio (SatO<sub>2</sub>/FiO<sub>2</sub>) using an independent data set. <b><i>Methods:</i></b>...
Abstract Objectives To compare the efficacy of intra‐tracheal (IT) surfactant/budesonide (SB) with that surfactant alone (S) in reducing rate bronchopulmonary dysplasia (BPD) at 36 weeks post‐menstrual age (PMA), we included extremely preterm very low birth weight (VLBW) infants severe respiratory distress syndrome (RDS) our tertiary neonatal level care unit (Padua, Italy). Study Design A retrospective chart review two cohorts VLBW neonates (<28 +0 gestation weeks, [BW] < 1500 g) born...
Perinatal asphyxia (PA) still occurs in about three to five per 1,000 deliveries developed countries; 20% of these infants show hypoxic-ischemic encephalopathy (HIE) on brain magnetic resonance imaging (MRI). The aim our study was apply metabolomic analysis newborns undergoing therapeutic hypothermia (TH) after PA identify a distinct metabotype associated with the development HIE MRI. We enrolled 53 born at >35 weeks gestation PA: 21 them showed MRI (the “HIE” group), and 32 did not “no...
Abstract Purpose Few guidelines exist for the perioperative management (PM) of neonates with surgical conditions (SC). This study examined current neonatal PM in Italy . Methods We invited 51 intensive care units pediatric surgery their institution to participate a web-based survey. The themes included (1) involvement neonatologist during PM; (2) spread bedside (BS); (3) critical issues concerning operating rooms (OR) and actions aimed at improving PM. Results Response rate was 82.4%. is...
We analyzed and compared variations in the urinary metabolome, as well postnatal clinical outcomes among preterm infants, based on timing of antenatal corticosteroid (ACS) administration response to labor onset their mothers. This was a prospective observational study held Neonatal Intensive Care Unit, Department Woman's Child's Health, Padova University Hospital (Italy). A urine sample obtained from each patient within 24 h birth; Mass Spectrometry-based untargeted metabolomics analysis...
Abstract A 4‐year‐old girl with clinical and laboratory signs of Kawasaki disease ( KD ) was hospitalized given intravenous immunoglobulin plus aspirin therapy, rapid defervescence improvement, discharged 48 hours after admission. At the time her follow‐up echocardiography on day 14, orange‐brown pigmentation nail beds noticed confirmed dermoscopy. No clear association between chromonychia has been demonstrated, although reports case series suggest a possible link these two entities. We that...