Stefano Martinelli
A5006805430- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Respiratory Support and Mechanisms
- Congenital Diaphragmatic Hernia Studies
- Congenital Heart Disease Studies
- Hemodynamic Monitoring and Therapy
- Infant Development and Preterm Care
- Reproductive tract infections research
- Neonatal and fetal brain pathology
- Syphilis Diagnosis and Treatment
- Urinary Tract Infections Management
- Hearing Loss and Rehabilitation
- Non-Invasive Vital Sign Monitoring
- Anesthesia and Neurotoxicity Research
- Neonatal and Maternal Infections
- Renal function and acid-base balance
- Bacterial Identification and Susceptibility Testing
- Ultrasound in Clinical Applications
- COVID-19 Impact on Reproduction
- Retinopathy of Prematurity Studies
- Antimicrobial Resistance in Staphylococcus
- Political and Social Issues
- Cellular Mechanics and Interactions
- Oil and Gas Production Techniques
- Diverse Research and Applications
Ospedale Maggiore
2022-2025
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2011-2024
Metropolitana Milanese (Italy)
2022
RELX Group (United States)
2022
Academic Pediatric Association
2022
Azienda Socio Sanitaria Territoriale Lariana
2020-2021
Maria Eleonora Hospital
2021
Azienda USL di Bologna
2017
University of Bologna
2017
Early surfactant followed by extubation to nasal continuous positive airway pressure (nCPAP) compared with later and mechanical ventilation (MV) reduce the need for MV, air leaks, bronchopulmonary dysplasia. This randomized, controlled trial investigated whether prophylactic nCPAP early application selective would MV in first 5 days of life.A total 208 inborn infants who were born at 25 28 weeks' gestation not intubated birth randomly assigned or within 30 minutes birth. Outcomes assessed...
ObjectiveTo investigate the efficacy and safety of nebulized poractant alfa (at 200 400 mg/kg doses) delivered in combination with nasal continuous positive airway pressure compared alone premature infants diagnosed respiratory distress syndrome.Study designThis randomized, controlled, multinational study was conducted at 280/7 to 326/7 weeks gestation. The primary outcome incidence failure first 72 hours life, defined as needing endotracheal surfactant and/or mechanical ventilation owing...
Abstract Bronchiolitis is a common cause of hospitalization in infants. The long-lasting impact hygiene and social behavior changes during the pandemic on this disease debated. We investigated prevalence hospitalized cases, clinical severity, underlying risk factors before pandemic. study was conducted 27 hospitals Italy included infants for bronchiolitis following four periods: July 2018-March 2019, 2020-March 2021, 2021-March 2022, 2022-March 2023. Data demographics, neonatal gestational...
Antenatal and postnatal treatment with dexamethasone (DEX) may negatively affect the neuropsychological development in children. Maternal anti-Ro/Sjögren's syndrome A (SSA) antibodies also be associated learning disabilities offspring.To assess babies exposed to very high dosages of DEX utero, whose mothers were anti-Ro/SSA positive.13 children congenital complete heart block (CHB) (11 2 not DEX) 3 healthy siblings, all anti-Ro/SSA-positive women, evaluated. 11 preschool-aged (5 boys)...
Vaccination against SARS-CoV-2 has been demonstrated to be safe during gestation. Nevertheless, there are no robust data investigating the entity of maternal antibodies’ transmission through placenta newborn and persistence antibodies in babies’ serum. The objective this study is assess antibody kinetics among newborns first months life. Women having received one or two doses anti-SARS-CoV-2 mRNA-vaccines pregnancy at any gestational age, their newborns, were recruited followed-up over 9...
Vancomycin-resistant enterococci (VRE) are a major cause of healthcare-associated infections (HAIs). However, the clinical significance VRE colonization and subsequent risk infection in hospitalized patients not fully established. Prolonged hospital stays have been observed neonates colonized by VRE. The mortality rate pediatric with ranges from 0% to 42% both endemic outbreak settings, often occurring VRE-colonized neonates. Host bacterial factors associated worse outcome understood yet. We...
Importance Respiratory distress syndrome and feeding intolerance are common conditions that often associated with preterm infants. Showing similar efficacy, nasal continuous positive airway pressure (NCPAP) heated humidified high-flow cannula (HHHFNC) the most widespread noninvasive respiratory support (NRS) in neonatal intensive care units, but their effect on is unknown. Objective To evaluate of NCPAP vs HHHFNC high-risk infants syndrome. Design, Setting, Participants This multicenter...
This prospective observational study aimed to evaluate whether lung fluids, assessed by ultrasonography and transthoracic electrical bioimpedance (TEB), may be influenced the presence of a haemodynamically significant patent ductus arteriosus (hsPDA) in very preterm infants during transitional period. Infants < 32 weeks gestational age (GA) admitted neonatal intensive care units IRCCS AOU Bologna Niguarda Metropolitan Hospital Milan (Italy) underwent daily assessment ultrasound score (LUS)...
Although beneficial in clinical practice, the INtubate-SURfactant-Extubate (IN-SUR-E) method is not successful all preterm neonates with respiratory distress syndrome, a reported failure rate ranging from 19 to 69 %. One of possible mechanisms responsible for unsuccessful IN-SUR-E method, requiring subsequent re-intubation and mechanical ventilation, inability lung achieve maintain an "optimal" functional residual capacity. The importance recruitment before surfactant administration has been...
Aplasia cutis congenita (ACC) is an inborn skin defect, variably associated with absence of the underlying subcutaneous fat and bone. Frieden IJ proposed a classification system for ACC consisting 9 groups according to lesion distribution malformations. We report child resembling group 5, extensive truncal limb defects fetus papyraceous, so-called vanishing twin syndrome. According our experience, risk developing payraceous unpredictable, although abortion occurred during first weeks...
Abstract Background Ophthalmia neonatorum is an acute conjunctivitis that occurs in newborns within the first month of life. The most serious infections are due to Chlamydia trachomatis and Neisseria gonorrhoeae , may cause permanent damages. use ophthalmic prophylaxis varies widely around world, according different health socio-economic contexts. To date Italy there no a clear legislation regarding ophthalmia at birth. Methods We invited all birth centers carry out retrospective survey...
Ophthalmia neonatorum (ON) refers to any conjunctivitis occurring in the first 28 days of life. In past Neisseria gonorrhoeae was most common cause ON. It decreased with introduction prophylaxis at birth instillation silver nitrate 2% (the Credè's method prophylaxis). Today, term ON is used define other bacterial infection, particular due Chlamydia Trachomatis. Currently, WHO reccomends topical ocular for prevention gonococcal and chlamydial all neonates. On contrary, several European...
To evaluate the rate of postnatal infection during first month life in neonates born to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive mothers predominant circulation omicron (B.1.1.529) variant.This prospective, 10-center study enrolled infected by SARS-CoV-2 at delivery and their infants, if both were eligible for rooming-in, between December 2021 March 2022. Neonates screened RNA 1 day (DOL), 3 DOL, before discharge, twice after hospital discharge. Mother-infant...
Objective This study aimed to describe the first two cases of electrical cardiometry applied newborn with hypoplastic left heart syndrome for hemodynamical assessment in days life before surgical correction and see if this can help decision making process these patients. Study Design We case series full-term Neonatal Intensive Care Unit, ASST Grande Ospedale Metropolitano Niguarda, between December 2019 January 2020. Results Case 1 was persistently hemodynamically stable prostaglandin E1...
Objective Electrical cardiometry is an impedance-based monitoring technique that provides data on several hemodynamic parameters in a noninvasive way. There limited information clinical utility of the application this neonates. Study Design In study, we describe case preterm neonate born at 302/7 weeks gestational age who developed severe systemic infection with fluid refractory septic shock day 2 life. Discussion was used and proved very helpful real-time guiding choice dosing most...
There is currently no worldwide agreement on the real need to administer conjunctival antibiotics neonates at birth prevent neonatal conjunctivitis (usually defined as ophthalmia neonatorum) by Chlamydia trachomatis and Neisseria gonorrhoeae. Therefore, there wide variability in antibiotic administration, conditioned mainly social health context. In Italy, a law enacted 1940 required doctors midwives ophthalmic prophylaxis with 2% silver nitrate all newborns birth. This was repealed 1975...