A5014191430- Neonatal and Maternal Infections
- Antibiotic Resistance in Bacteria
- Nosocomial Infections in ICU
- Pneumonia and Respiratory Infections
- Antifungal resistance and susceptibility
- Urological Disorders and Treatments
- Urinary Tract Infections Management
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Pediatric Urology and Nephrology Studies
- Congenital Anomalies and Fetal Surgery
- Renal and related cancers
- Infant Nutrition and Health
- Diabetes and associated disorders
- Congenital Ear and Nasal Anomalies
- Genomics and Rare Diseases
- Breastfeeding Practices and Influences
- Child Nutrition and Feeding Issues
- Genomic variations and chromosomal abnormalities
- Lipid metabolism and disorders
- Congenital Diaphragmatic Hernia Studies
- Respiratory viral infections research
- Clinical Nutrition and Gastroenterology
- Systemic Sclerosis and Related Diseases
- Infant Health and Development
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo
2023-2024
University of Palermo
2014-2024
Servizio Sanitario Nazionale
2015
The discovery of antimicrobial drugs has led to a significant increase in survival from infections; however, they are very often prescribed and administered, even when their use is not necessary appropriate. Newborns particularly exposed infections due the poor effectiveness immaturity immune systems. For this reason, Neonatal Intensive Care Units (NICUs), decisive life-saving, it must be started promptly ensure its consideration possible rapid evolution infection towards sepsis....
Colonization and infection by multidrug-resistant gram-negative bacilli (MDR GNB) in neonatal intensive care units (NICUs) are increasingly reported. We conducted a 5-year prospective cohort surveillance study tertiary NICU of the hospital "Paolo Giaccone," Palermo, Italy. Our objectives were to describe incidence trends MDR GNB colonization characteristics most prevalent organisms identify risk factors for colonization. Demographic, clinical, microbiological data prospectively collected....
Cat eye syndrome (CES) is a rare chromosomal disease, with estimated incidence of about 1 in 100,000 live newborns. The classic triad iris coloboma, anorectal malformations, and auricular abnormalities present 40% patients, other congenital defects may also be observed. typical associated cytogenetic anomaly relies on an extra chromosome, derived from inverted duplication short arm proximal long chromosome 22, resulting partial trisomy or tetrasomy such regions (inv dup 22pter-22q11.2).We...
Antimicrobial resistance in neonatal intensive care unit (NICU) patients is a threat, due to the frequent use of antimicrobial treatment and invasive devices fragile babies. Since 2014 an active surveillance program multidrug-resistant Gram-negative bacteria (MDR-GNB) carriage has been place five NICUs Palermo, Italy. In 2017 increase prevalence MDR-GNB, particular extended-spectrum β-lactamases-producing Klebsiella pneumoniae (ESBL-KP), was observed "Civico" hospital NICU.To assess impact...
Abstract Background Carnitine palmitoyltransferase II (CPT II) deficiency is a rare inborn error of mitochondrial fatty acid metabolism with autosomal recessive pattern inheritance. Its phenotype highly variable (neonatal, infantile, and adult onset) on the base mutations CPT gene. In affected subjects, long-chain acylcarnitines cannot be subdivided into carnitine acyl-CoA, leading to their toxic accumulation in different organs. Neonatal form most severe, all reported patients died within...
Background: Antimicrobial resistance (AMR) is a topic of concern, especially in high-level care departments like neonatal intensive units (NICUs). The systematic use an “active” epidemiological surveillance system allows us to observe and analyze any changes microbial distribution, limiting the risk healthcare-associated infection (HAI) development. Methods: We have conducted longitudinal observational study five NICUs Palermo, comparing “pre-pandemic period” (March 2014–February 2020) with...
We performed a 1-year prospective surveillance study on MRSA colonization within the five NICUs of metropolitan area Palermo, Italy. The purpose was to assess epidemiology in NICU from network perspective.Transfer patients between during 2014 traced based annual hospital discharge records. In period February 2014-January 2015, B, at University teaching hospital, nasal swabs all infants were collected weekly, whereas other four (A, C, D, E) 4 week-intervals time. isolates submitted antibiotic...
Abstract Background Tumors are rare in neonatal age. Congenital mesoblastic nephroma (CMN) is a usually benign renal tumor observed at birth, or the first months of life. It may also be identified prenatally and associated with polyhydramnios leading to preterm delivery. Effective treatment surgical most cases, consisting total nephrectomy. In literature, very few studies report on management such disease, even less those describing its uncommon complications. Cases presentation We two...
Intestinal atresia type III B (apple peel) and gastroschisis are both congenital malformations who require early surgical correction in neonatal age. Their association is very rare. We present the case of a full term infant with partial apple peel ileal small defect anterior abdominal wall, complicated by utero intestinal perforation subsequent meconial peritonitis. observed intestine, involvement terminal ileus savings jejunum large part proximal ileum, wall herniation few bowel loops,...
Fungal infections are an important cause of morbidity and mortality in neonatal intensive care units (NICUs). The identifi-cation specific risk factors supports pre-vention candidemia neonates. Effec-tive prophylactic strategies have recently become available, but the identification adequate management high-risk in-fants is still a priority. Prior colonization key factor for candidemia. For this reason, surveillance studies to monitor in-cidence, species distribution, antifun-gal...
Gastroschisis is an abdominal wall defect, typically located to the right of umbilical cord, requiring early surgical treatment shortly after birth. Affected patients can be identified during intrauterine life with US and should delivered in referral hospitals where a multisciplinary approach provided, involving neonatologists, clinical geneticists, surgeons other specialists. These require complex management Neonatal Intensive Care Unit (NICU) long term follow-up discharge. Exceed acute...
Introduction: Fungal infections are an important cause of increased morbidity and mortality in infants admitted to neonatal intensive care units (NICUs). In VLBW infants, Candida (C.) albicans is the third most common late onset sepsis (LOS). The overall incidence candidemia NICU increasing because longer survival invasive procedures related with extremely preterm infants. Prevention neonates supported by identification adequate management specific risk factors, including low birth weight,...
Abstract Background Tumors are rare in neonatal age. Congenital mesoblastic nephroma (CMN) is a usually benign renal tumor observed at birth, or the first months of life. It may also be identified prenatally, and associated with polyhydramnios leading to preterm delivery. Effective treatment surgical most cases, consisting total nephrectomy. In literature, very few studies report on management such disease, even less those describing its uncommon complications. Cases presentation We two...
Abstract Background: Antimicrobial resistance in Neonatal Intensive Care Unit (NICU) patients is a threat, due to the large use of antimicrobial treatment and invasive devices fragile babies.Since 2014 an active surveillance program multidrug-resistant Gram-negative bacteria (MDR-GNB) carriage place five NICUs Palermo, Italy. In 2017 increase prevalence MDR-GNB particular extended-spectrum β-lactamases-producing Klebsiella pneumoniae (ESBL-KP) was observed “Civico” hospital NICU. Aim: To...
Abstract Background: Antimicrobial resistance in Neonatal Intensive Care Unit (NICU) patients is a threat, due to the large use of antimicrobial treatment and invasive devices fragile babies.Since 2014 an active surveillance program multidrug-resistant Gram-negative bacteria (MDR-GNB) carriage place five NICUs Palermo, Italy. In 2017 increase prevalence MDR-GNB particular extended-spectrum β-lactamases-producing Klebsiella pneumoniae (ESBL-KP) was observed “Civico” hospital NICU. Aim: To...