A5031110389- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Infant Nutrition and Health
- Neuroscience of respiration and sleep
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Congenital Diaphragmatic Hernia Studies
- Anesthesia and Neurotoxicity Research
- Breastfeeding Practices and Influences
- Metabolism and Genetic Disorders
- Neonatal and Maternal Infections
- Infant Development and Preterm Care
- Sepsis Diagnosis and Treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Neuropeptides and Animal Physiology
- Gestational Diabetes Research and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Preterm Birth and Chorioamnionitis
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Non-Invasive Vital Sign Monitoring
University of Chieti-Pescara
2017-2025
Maastricht University
2020-2021
Azienda Sanitaria Locale Alessandria
2011-2020
Medical University of Silesia
2019
IRCCS Materno Infantile Burlo Garofolo
2019
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
2008-2019
Hubei University of Technology
2019
Medical University of Lodz
2019
Boston Children's Hospital
1999-2015
IRCCS Policlinico San Donato
2010-2013
Abstract Objectives To evaluate the strength of association between maternal and pregnancy characteristics risk adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis a multinational, cohort study on all consecutive pregnant women laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 73 centers 22 different countries. A case was defined as positive result real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay...
To date, we have little knowledge on the overall metabolic status of neonates with intrauterine growth retardation (IUGR). In last few years, analysis metabolomics has assumed an important clinical role in identifying "disorders" profile patients. The aim this work been to analyze urine profiles IUGR and compare them controls define patterns associated pathology. our knowledge, is first study performed IUGR. Recruited for were 26 diagnosed neonatal period weight at birth below 10th...
Studies suggest that giving newly born preterm infants sustained lung inflation (SLI) may decrease their need for mechanical ventilation (MV) and improve respiratory outcomes.We randomly assigned at 25 weeks 0 days to 28 6 of gestation receive SLI (25 cm H2O 15 seconds) followed by nasal continuous positive airway pressure (nCPAP) or nCPAP alone in the delivery room. were delivered using a neonatal mask T-piece ventilator. The primary end point was MV first 72 hours life. secondary points...
The diagnosis of perinatal insults currently relies on adequate documentation general medical and obstetric factors radiologic laboratory assessments. measurement brain constituents such as S100B protein may offer an alternative direct indicator cell damage in the nervous system when clinical assessments are still silent has additional advantage providing a quantitative extent lesions. been measured by several immunoassays biological fluids (i.e., cerebrospinal fluid, blood, amniotic urine)...
The term S100 refers to members of a multigenic family calcium-modulated proteins, mostly low molecular mass (∼10 000 Da), first identified as protein fraction detectable in the brain and called because its solubility solution 100 g/L ammonium sulfate (1). seems be most abundant glial cells, although presence neuronal subpopulations has also been reported (2)(3). The biological role this within cell populations that contain it not completely elucidated. possibility an extracellular for...
Abstract During 2006, 82 samples of human mature milk were collected at Italian hospitals and checked for aflatoxin M1 (AFM1) ochratoxin A (OTA) by immunoaffinity column extraction HPLC. AFM1 was detected in four (5%) (ranging from < 7 ng/L to 140 ng/L; mean level: 55.35 ng/L); OTA 61 (74%) 5 405 30.43 ng/L. levels significantly higher ( p ⪇ 0.05) habitual consumers bread, bakery products cured pork meat. No other statistically significant differences observed although pasta = 0.059),...
Background Perinatal asphyxia (PA) is a leading cause of mortality and morbidity in newborns: its prognosis depends both on the severity immediate resuscitation to restore oxygen supply blood circulation. Therefore, we investigated whether measurement S100B, consolidated marker brain injury, salivary fluid PA newborns may constitute useful tool for early detection asphyxia-related injury. Methods We conducted cross-sectional study 292 full-term admitted our NICUs, whom 48 suffered 244...
In utero exposure to maternal hyperglycemia and obesity can trigger detrimental effects in the newborn through epigenetic programming. We aimed assess DNA methylation levels promoters of
Abstract Background The issue of retreatment with surfactant infants respiratory distress syndrome (RDS) has been poorly investigated. Our aim was to identify possible clinical predictors the need for multiple doses in a large cohort very preterm infants. Methods Data were analyzed from three previous studies on born between 25 + 0 and 31 6 weeks gestation RDS who treated surfactant. Results We studied 448 Among them 306 (68%) single dose 142 (32%) doses. Multivariable mixed effects logistic...
Background Adrenomedullin (AM) is a potent angiogenic, antioxidant and anti-inflammatory peptide protecting the developing lung from injury due to bronchopulmonary dysplasia (BPD) of preterm infant. At this stage, no data on potential effects chorioamnionitis (CA) occurrence glucocorticoids (GC) administration AM in lungs are still lacking.
Abstract Background To validate the role of Activin A in early diagnosis and prognosis preterm newborns at risk for intraventricular hemorrhage neurological sequelae by means cerebral ultrasound magnetic resonance imaging (MRI), currently considered standard care procedures. Methods We conducted an observational case–control study 46 newborns, 23 with (IVH group) controls matched gestational age. Standard clinical, laboratory, monitoring procedures urine measurement were performed four...
Introduction Improving the quality of life for preterm children is a global health priority, given their vulnerability to neurocognitive impairments and adverse consequences. Lack post-hospital care further exacerbates these risks, necessitating effective interventions during neonatal period. This protocol pilot study aims investigate effects touch interventions, including physiotherapy manual therapy (OMT), on brain activity in moderately infants using functional magnetic resonance imaging...
Intraventricular hemorrhage (IVH) is the most common form of cerebral in preterm infants, affecting ∼15–20% (1). Despite accurate postnatal monitoring, IVH difficult to diagnose during first 72 h after birth because at this stage, clinical symptoms and radiologic assessment brain damage may still be silent (2). The availability these patients quantitative indicators suggesting subclinical lesions a time when monitoring are unable detect bleeding therefore important. Furthermore,...
Objective Hypoxic-ischemic encephalopathy (HIE) is one of the major causes perinatal mortality and morbidity. To date, there are no reliable methods to detect which infants will develop brain damage after asphyxia insult. Design Setting Prospective study conducted in three tertiary departments neonatology from December 1999 July 2002. Participants A total 44 with 68 control infants. Intervention Routine laboratory variables, neurologic patterns, ultrasound imaging, urine concentrations S100B...