A5034331450- Maternal and fetal healthcare
- Pregnancy and preeclampsia studies
- COVID-19 Impact on Reproduction
- Urological Disorders and Treatments
- Gestational Diabetes Research and Management
- Maternal and Perinatal Health Interventions
- Cleft Lip and Palate Research
- Birth, Development, and Health
- Pediatric Urology and Nephrology Studies
- Prenatal Screening and Diagnostics
- Global Maternal and Child Health
- Bariatric Surgery and Outcomes
- RNA modifications and cancer
- Reproductive Health and Contraception
- Congenital Anomalies and Fetal Surgery
- Cardiovascular Issues in Pregnancy
- Vascular anomalies and interventions
- Fetal and Pediatric Neurological Disorders
- Renal and related cancers
- Pelvic floor disorders treatments
- Connective tissue disorders research
- Nutrition, Genetics, and Disease
- Ureteral procedures and complications
- Pregnancy-related medical research
- Congenital Diaphragmatic Hernia Studies
Charité - Universitätsmedizin Berlin
2021-2024
Klinikum im Friedrichshain
2020-2022
Abstract Objectives To evaluate the strength of association between maternal and pregnancy characteristics risk adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis a multinational, cohort study on all consecutive pregnant women laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 73 centers 22 different countries. A case was defined as positive result real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay...
(1) Background: Data on coronavirus 2 infection during pregnancy vary. We aimed to describe maternal characteristics and clinical presentation of SARS-CoV-2 positive women requiring intensive care treatment for COVID-19 postpartum period based data a comprehensive German surveillance system in obstetric patients. (2) Methods: from Related Obstetric Neonatal Outcome Study (CRONOS), prospective multicenter registry pregnant women, was analyzed with respect ICU treatment. All were included...
Mechanical methods have gained growing interest for pre-induction cervical ripening in women with an unripe cervix, since they a better safety profile compared to prostaglandins. Balloon catheters been the gold standard method decades, while there was lack of data on synthetic osmotic dilators. Not until 2015, when Dilapan-S approved by Food and Drug Administration (FDA) induction labor, numerous studies published use this field. The rate vaginal deliveries associated ranges from 61.6 81.7%,...
Abstract Introduction Pregnant women and their offspring represented a vulnerable patient collective during the Covid-19 pandemic. Beyond direct effect of SARS-CoV-2 via vertical transmission, an indirect impact on fetus can occur through placental lesions deteriorating villous function. We performed histopathological analysis placentas parturients with compared to healthy controls. Methods materials Between February 2022 July we conducted prospective case–control study analyzing specimens...
Gestational diabetes (GDM) is a frequent complication during pregnancy. We aimed to develop score predict future insulin dependency in gestational (GDM). Data from 1611 patients Charité Berlins clinic 2015 2022 were utilized. A stepwise backwards regression, including patient characteristics obtained at the initial presentation, was performed. Predictors examined included age, fasting blood glucose level, levels one and two hours after oral tolerance test, pre-pregnancy BMI, number of...
In den vergangenen 20 Jahren hat sich der Anteil eingeleiteten Geburten in Ländern mit hohem Durchschnittseinkommen nahezu verdoppelt. Deutschland lag er 2020 bei 21,8% 1. Geburtseinleitungen unreifer Zervix sind längerer Behandlungsdauer, höheren Kosten, schmerzhafteren Wehen und geringerer Akzeptanz Schwangeren verbunden 2. Aufgrund kontraktionsbedingter uteriner Hypoperfusion ist Stress für die feto-plazentare Einheit erhöht, was verminderter fetaler Reserve zu fetalem Distress führen...
The fifth of the United Nations' Millennium Development Goals proposed for 2000-2015 was to improve maternal health, which has only partially been achieved. Worldwide, mortality ratio is currently estimated at 216/100.000 livebirths, compared 380/100,000 in 1990. As yet, there no published comprehensive analysis data as it pertains Berlin and by extension Germany. Aim study evaluate analyze rate a result shortcomings healthcare provision identify possible solutions.The Institute Quality...
Background Critical illness during pregnancy puts mother and fetus at serious risks. Current literature regarding the effect of coronavirus 2 (SARS-CoV-2) describes an increased risk for maternal mortality as well high rates preterm delivery, however data vary depend on respective health care system. We aimed to describe characteristics clinical presentation SARS-CoV-2 positive pregnant postpartum women requiring intensive treatment COVID-19 in Germany, order explore factors severe courses...
SMPD4 loss is a rare complex condition that affects fetal neurodevelopmental delay and associated with poor neonatal outcome early death in infancy. This genetic detectable via exome sequencing. A detailed transabdominal ultrasound examination at 22+3 gestational weeks indicated male fetus an estimated weight of 590g (65th percentile), simplified gyral pattern, cerebellar hypoplasia, Rocker bottom feet (talus verticalis), clenched fists. Fetal movements were sparse. The amniotic fluid was...
Oral communication abstractsdisorder (22%).All recurrent cases (2/2, 100%) and those who received fetal therapy (3/3, have definite molecular diagnosis.Two survived fetuses were diagnosed at first third trimester, respectively.Three had neonatal death six couples terminated the pregnancies.Two novel founder variants found (HSPG2 BBS2).Conclusions: Trio-WES is an effective tool to ascertain genetic diagnosis for NIHF would discover more causative genes match exhibited prenatal phenotypes.
Creation of objective tools may improve the predictive ability prenatal ultrasound to predict postnatal renal function.
Conclusions: Cortisol level, cervical length, PCA display poor sensitivity and
Isocitrate dehydrogenase (IDH) 1 loss may lead to a rare neurodevelopmental disorder called metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria, including severe skeletal and cerebral anomalies. So far, no prenatal case of IDH1 has been reported in literature. Point mutations IDH1/2 genes are described distinct cancers, premalignant diseases inherited metabolic disorders. A 27-year-old Gravida I Para 0 presented at 21+1 gestational weeks for second trimester anomaly screening. The...
muscle function in both skeletal and heart muscle, lactic acidosis progressive brain damage.Reports of biallelic pathogenic variants COQ9 are extremely rare this mitochondrial condition would explain the cardiomegaly contractures seen on scan.The fit with a myopathy extends known phenotype.The couple could have invasive prenatal testing for future pregnancies.In individuals affected by Rubinstein-Taybi, reduced amounts CREB binding protein results short stature, intellectual disability,...
Non-invasive prenatal testing (NIPT) is a well-established option that offers early information ab chromosomal abnormalities, such as Trisomy 21, 18 and 13 by cell-free placenta It was introduced in Germany 2012 nowadays method especially for women with an intermediate risk at the first trimester ultrasound screening. However, it sometimes also used maternal request to avoid procedure related pregnancy loss after invasive testing. In reported case 31-year-old patient – G1, P0 referred 14...
A normal placentation is of fundamental importance for an undisturbed course pregnancy. Abnormal placental development and implantation can result in various pathologies, such as IUGR pre-eclampsia. It be assessed by maternal biochemical markers but also Doppler the uterine arteries. However, actual blood flow area nutrient exchange, parenchyma, not routinely examined. In order to improve depiction slow flows, several novel power techniques that analyse low velocities using advanced clutter...
Gestational diabetes is a common complication during pregnancy, associated with adverse fetal and maternal outcome. There strong association of blood glucose levels increased birthweight subsequent complications. Data from gestational consultation clinic at the Charité University hospital in Berlin, Germany, was analysed retrospectively 2015 until 2022. 1664 cases were included analysis. The oral tolerance test (oGTT) categorised into isolated fasting hyperglycemia (GDM-IFH), postprandial...
Hintergrund Heutzutage ist die Prävalenz von Übergewicht und Adipositas bei jungen Frauen deutlich erhöht. Für Schwangerschaft Geburt dies ein bedeutsamer Risikofaktor. In den USA sind mehr als Hälfte der zu Beginn ihrer übergewichtig mit einem BMI 25,0. übermäßige Gewichtszunahme hat Auswirkung auf kindliche mütterliche Gesundheit.