A5077426200- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Urological Disorders and Treatments
- Bone Tissue Engineering Materials
- Ureteral procedures and complications
- Organ Donation and Transplantation
- Cellular and Composite Structures
- Renal and Vascular Pathologies
- Kidney Stones and Urolithiasis Treatments
- Bladder and Urothelial Cancer Treatments
- Organ Transplantation Techniques and Outcomes
- Pregnancy and preeclampsia studies
Radboud University Medical Center
2015-2019
Radboud University Nijmegen
2015-2019
Radboud Institute for Molecular Life Sciences
2016-2019
University Medical Center
2018
A readily available artificial urinary conduit might be substituted for autologous bowel in standard diversions and minimize associated complications. However, the use of large constructs remains challenging as host cellular ingrowth and/or vascularization is limited. We investigated large, reinforced, collagen based tubular a diversion porcine model compared subcutaneously pre-implanted to cell seeded basic constructs.Reinforced were prepared from type I biodegradable Vicryl® meshes through...
To restore damaged organ function or to investigate mechanisms, it is necessary prepare replicates that follow the biological role model as faithfully possible. The interdisciplinary field of tissue engineering has great potential in regenerative medicine and might overcome negative side effects replacement organs. In particular, tubular structures genitourinary tract, such ureter urethra, are challenging because their complexity special milieu gives rise incrustation, inflammation stricture...
Clinical implementation of novel products for tissue engineering and regenerative medicine requires a validated sterilization method. In this study, we investigated the effect γ-irradiation EtO degassing on material characteristics in vitro template remodeling hybrid tubular constructs large animal model. Hybrid templates were prepared from type I collagen Vicryl polymers sterilized by 25 kGray or degassing. The extensively studied, including tensile strength analysis degradation studies....
Regenerative medicine, tissue engineering and biomedical research give hope to many patients who need bio-implants. Tissue applications have already been developed based on bioreactors. Physiological ureter implants, however, do not still function sufficiently, as they represent tubular hollow structures with very specific cellular alignments consisting of several cell types. The aim this study was a develop new bioreactor system seamless, collagenous, OPTIMAIX 3D prototype sponge scaffold...
Abstract In vivo monitoring of tissue‐engineered constructs is important to assess their integrity, remodeling, and degradation. However, this challenging when the contrast with neighboring tissues low, necessitating labeling agents (CAs), but current CAs have limitations (i.e., toxicity, negative contrast, label instability, and/or inappropriate size). Therefore, a naturally derived hemin‐L‐lysine (HL) complex used as potential CA collagen‐based templates for magnetic resonance imaging...
It is common to test medical devices in large animal studies that are or could also be used humans. In this short report we describe the use of a ureteral J-stent for evaluation biodegradable tubular constructs tissue reconstruction, and regeneration ureters Saanen goats. Similarly previous study pigs, was blindly inserted until some resistance met. During goats after three months, perforation renal cortex by stent observed four out seven animals. These results indicated blind placement not...
A normal placentation is of fundamental importance for an undisturbed course pregnancy. Abnormal placental development and implantation can result in various pathologies, such as IUGR pre-eclampsia. It be assessed by maternal biochemical markers but also Doppler the uterine arteries. However, actual blood flow area nutrient exchange, parenchyma, not routinely examined. In order to improve depiction slow flows, several novel power techniques that analyse low velocities using advanced clutter...