A5081830489- Ultrasound in Clinical Applications
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Airway Management and Intubation Techniques
- Neuroscience of respiration and sleep
- Atomic and Subatomic Physics Research
- Pleural and Pulmonary Diseases
- Radiation Dose and Imaging
- Neonatal and fetal brain pathology
- Respiratory Support and Mechanisms
- Neonatal Health and Biochemistry
- Obstructive Sleep Apnea Research
- Phonocardiography and Auscultation Techniques
- Radiology practices and education
- Congenital Heart Disease Studies
- Language Development and Disorders
- Optical Imaging and Spectroscopy Techniques
- Infant Development and Preterm Care
- Neurosurgical Procedures and Complications
- Photoacoustic and Ultrasonic Imaging
- Intracerebral and Subarachnoid Hemorrhage Research
- Rabbits: Nutrition, Reproduction, Health
- Spectroscopy Techniques in Biomedical and Chemical Research
- Non-Invasive Vital Sign Monitoring
- EEG and Brain-Computer Interfaces
Azienda Ospedaliera Universitaria Integrata Verona
2025
Ospedale Santa Maria della Misericordia di Udine
2013-2021
University of Udine
1988-2021
Presidio Ospedaliero
2017
Misericordia University
2014
Ospedale Sant Antonio
2006-2011
Istituto di Fisiologia Clinica
1996
Case Western Reserve University
1993
Rainbow Babies & Children's Hospital
1993
Respiratory distress syndrome (RDS) is a severe form of neonatal respiratory which occurs almost exclusively in premature infants. At present, the diagnosis based on radiological findings and clinical course. Lung ultrasound RDS has not yet been fully assessed.The aim study was to define ultrasonographic appearance evaluate its relevance.Lung sonography performed 40 newborn infants with signs (mean gestational age 27.2 +/- 2.7 weeks, mean birth weight 1,057 361 g) 15 preterm without 30.4 3.4...
<i>Background:</i> Transient tachypnea of the newborn (TTN) is a mild form neonatal respiratory distress which early in its course needs to be differentiated from other severe disorders. At present diagnosis based on radiological findings and clinical course. Lung sonography TTN has not yet been assessed. <i>Objectives:</i> The aim study was define ultrasonographic appearance evaluate relevance. <i>Methods:</i> performed 32 infants with signs within first...
<b><i>Background:</i></b> Lung ultrasound (LUS) is a promising technique for the diagnosis of neonatal respiratory diseases. Preliminary data has shown good sensitivity and specificity LUS in distress syndrome (RDS) transient tachypnea newborn (TTN). <b><i>Objective:</i></b> The aim this study was to calculate sensitivity, specificity, negative (NPV) positive predictive value (PPV) RDS TTN, using an external reader blinded clinical condition....
Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE Europe even more regions with lower level perinatal care. The only established therapy improve outcome these therapeutic hypothermia. Allopurinol xanthine oxidase inhibitor that reduces the production oxygen radicals as superoxide, which contributes secondary energy failure apoptosis neurons glial cells after...
To assess the reliability of lung sonography in neonates between physician interpreters with different degrees experience.We retrospectively reviewed sonograms from admitted to a neonatal intensive care unit respiratory distress first 24 hours life. The scans were selected; only patients available video clips documenting both hemithoraxes included. independently examined by 4 experienced observers blinded clinical data. interpreting physicians made codified sonographic diagnosis, and Cohen κ...
Abstract To understand language, humans must encode information from rapid, sequential streams of syllables – tracking their order and organizing them into words, phrases, sentences. We used Near‐Infrared Spectroscopy ( NIRS ) to determine whether human neonates are born with the capacity track positions in multisyllabic sequences. After familiarization a six‐syllable sequence, neonate brain responded change (as shown by an increase oxy‐hemoglobin) when two edge switched but not middle...
Abstract Background Despite therapeutic hypothermia (TH) and neonatal intensive care, 45–50% of children affected by moderate-to-severe hypoxic-ischemic encephalopathy (HIE) die or suffer from long-term neurodevelopmental impairment. Additional neuroprotective therapies are sought, besides TH, to further improve the outcome infants. Allopurinol — a xanthine oxidase inhibitor reduced production oxygen radicals subsequent brain damage in pre-clinical preliminary human studies cerebral ischemia...
ABSTRACT Introduction Lung ultrasound score (LUS) is used to predict the need for surfactant in preterm neonates. Its performance lower neonates with a gestational age (GA) ≥ 34 weeks. We developed score, thoracic (TUS), overcome shortcomings of LUS. Objectives To assess feasibility and diagnostic accuracy TUS evaluate oxygenation administration, compared Materials Methods This was prospective, multicenter, observational study. Preterm noninvasive ventilation GA between 24 + 0 36 6 weeks...
Lung ultrasound outperforms conventional radiology in the emergency diagnosis of pneumothorax and pleural effusions. Neonatologists pediatricians are now adapting lung to their specific clinical issues. The normal image is relatively unchanged throughout age span, whereas progressively fading B-lines (comet-tail artifacts) describe fluid-to-air transition neonatal lung. Also, an homogeneous white (hyperechogenic) with abnormalities absence spared areas accurate diagnosing respiratory...
Abstract Purpose To evaluate sensitivity, specificity and the safest cut‐offs of three predictive algorithms ( WINROP , ROPS core CHOP ROP ) for retinopathy prematurity ). Methods A retrospective study was conducted in centres from 2012 to 2014; 445 preterms with gestational age GA ≤ 30 weeks and/or birthweight BW 1500 g, additional unstable cases, were included. No‐ mild type 1 categorized. The analysed infants all parameters weight gain, oxygen therapy, blood transfusion) needed...
Objective: Recent ultrasonographic studies suggest that the administration of surfactant to preterm infants with respiratory distress syndrome (RDS) does not affect lung water clearance. The purpose study was also look at clearance in rabbits receiving surfactant.
We studied physiological and pharmacological maturation of cholinergic innervation to tracheal smooth muscle in piglets at three ages: < 7 days, 2-3 wk, 10 wk. Change tension was measured vivo from a segment normalized for its size. Electrical vagal stimulation induced significantly weaker increase days when compared with In studies employing before after topical application pirenzepine (an M1 muscarinic receptor blocker) vitro evaluating the inhibition [3H]quinuclidinyl benzilate (QNB)...
By exploiting a multichannel portable instrument for time-domain near-infrared spectroscopy (TD-NIRS), we characterized healthy neonates' brains in term of optical properties and hemodynamic parameters. In particular, assessed the absolute values absorption reduced scattering coefficients at two wavelengths, together with oxy-, deoxy- total hemoglobin concentrations, blood oxygen saturation brains. this study, 33 full-term neonates were tested, obtaining following median values: 0.28...
Abstract Introduction Survivors of extreme prematurity may have disrupted lung development. We hypothesized that the multiple breath washout (MBW) index Scond, which is intended to reflect ventilation inhomogeneity from conducting airways, could be a sensitive marker respiratory impairment in this group. Methods Spirometry, TLco, and MBW were cross‐sectionally evaluated at 8 14 years age children born <28 weeks between 2004 2010 Udine, Italy. Age‐matched controls term also included....
Significance Since birth, infants begin to learn a myriad of sounds. Yet our knowledge their abilities remember specific sounds is primarily based on habituation studies that presented them with massive repetitions single The present work opens vistas the study language acquisition and memory development by suggesting presence various during encoding does not impair recognition in newborns. Results also indicate coordinated interplay between temporal frontal regions brain supports newborns’...
Peripheral chemoreceptor activity was studied in nine healthy, unsedated neonates (with a mean (SD) postconceptional age of 39 (2) weeks and birth weight 3000 (400) g) by measuring the inhibition ventilation elicited five breaths 100% oxygen (Dejours technique). Changes tidal volume, frequency, minute were measured before after administration aminophylline (10 mg/kg mouth). Before hyperoxia induced decrease (from (SE) 825 (55) to 520 (30) ml/kg/min) as result reduction volume 12 (0.3) 8...
Abstract Peripheral chemoreceptors may be immature in neonatal animals, exhibiting maturational changes the perinatal period. Even though methylxanthines are respiratory stimulants, many premature neonates do not respond to them. Thus, we hypothesized that carotid body activity is necessary for aminophylline reverse hypoxia‐induced depression. We exposed 16 anesthetized newborn piglets (age 2‐7 days) hypoxia (inhalation of 12% oxygen) 5 min. Aminophylline (15 mg/kg iv) was administered...