A5032438442- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Cardiac Arrest and Resuscitation
- Congenital Diaphragmatic Hernia Studies
- Metabolism and Genetic Disorders
- Infant Development and Preterm Care
- Neurological and metabolic disorders
- Congenital Heart Disease Studies
- Palliative Care and End-of-Life Issues
- Gestational Diabetes Research and Management
- Neonatal Health and Biochemistry
- Birth, Development, and Health
- Mitochondrial Function and Pathology
- Maternal and Perinatal Health Interventions
- Anesthesia and Neurotoxicity Research
- Congenital Anomalies and Fetal Surgery
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Respiratory Support and Mechanisms
- Pediatric Pain Management Techniques
- Infant Nutrition and Health
- Blood transfusion and management
- Health disparities and outcomes
- Ethics and Legal Issues in Pediatric Healthcare
Hospital Universitario Dexeus
2023-2025
Sociedad Española de Nefrología
2019-2024
Hospital Quirónsalud Barcelona
2021-2024
Vall d'Hebron Hospital Universitari
2010-2022
Hospital Universitario Virgen de las Nieves
2018-2020
Universitat Autònoma de Barcelona
2018-2019
Hospital Universitari Sant Joan D'Alacant
2019
University of Alicante
2019
Hospital Materno-Infantil
2013-2017
Abstract Background Despite therapeutic hypothermia (TH) and neonatal intensive care, 45–50% of children affected by moderate-to-severe hypoxic-ischemic encephalopathy (HIE) die or suffer from long-term neurodevelopmental impairment. Additional neuroprotective therapies are sought, besides TH, to further improve the outcome infants. Allopurinol — a xanthine oxidase inhibitor reduced production oxygen radicals subsequent brain damage in pre-clinical preliminary human studies cerebral ischemia...
After more than 50 years of experience, newborn screening (NBS) programs represent one the most significant advancements in public health, particularly pediatric and neonatal care, benefiting almost 350 000 children annually Spain. Following inclusion congenital hearing loss 2003 for seven diseases by blood spot test 2014 as part population-wide program National Health System (NHS), advances have been achieved recent years. This progress is evident implementation critical heart diseases,...
<b><i>Background and Objectives:</i></b> Therapeutic interventions to improve the efficacy of whole-body cooling for hypoxic-ischemic encephalopathy (HIE) are desirable. Topiramate has been effective in reducing brain damage experimental studies. However, clinical setting information is limited a small number feasibility trials. We launched randomized controlled double-blinded topiramate/placebo multicenter trial with primary objective being reduce antiepileptic...
Objective Scientific evidence supports the use of less invasive surfactant administration (LISA) techniques, but certain issues may be limiting its generalized incorporation in clinical practice. The objectives were to determine level acceptance LISA techniques Spanish hospitals, types methods used, target population, and premedication administered. Study Design An online survey was designed sent various secondary/tertiary hospitals Spain. Results Among 67 neonatal units contacted, 44...
Abstract Therapeutic hypothermia (TH) initiated within 6 h from birth is the most effective therapeutic approach for moderate to severe hypoxic-ischemic encephalopathy (HIE). However, underlying mechanisms and effects on human metabolism are not yet fully understood. This work aims at studying evolution of several energy related key metabolites in newborns with HIE undergoing TH employing gas chromatography – mass spectrometry. The method was validated following stringent FDA requirements...
La Sociedad Española de Neonatología estableció en el año 2013 los niveles asistenciales las unidades neonatales España. Desde entonces, la natalidad nuestro país, así como universalización del conocimiento, técnicas y dispositivos tratamiento pacientes ha evolucionado significativamente. Esta situación obliga a una redefinición actuales basándose criterios calidad que permitan mejor comparabilidad entre supongan un impulso para mejora atención nuestros recién nacidos. The Spanish Society of...
Abstract Background Immediately after birth, the oxygen saturation is between 30 and 50%, which then increases to 85–95% within first 10 min. Over last years, recommendations regarding ideal level of initial fraction inspired (FiO 2 ) for resuscitation in preterm infants have changed from 1.0, room air low levels (< 0.3), up moderate concentrations (0.3–0.65). This leaves clinicians a challenging position, large multi-center international trial sufficient sample size that powered look at...
The pathogenesis and progression of hypoxic-ischemic encephalopathy (HIE), a major cause severe neurological disability mortality in the perinatal period, are shaped by interplay multiple processes, including inflammation, oxidative stress, excitotoxicity. We conducted longitudinal study to determine biomarkers stress inflammation noninvasive urine samples newborns with moderate/severe HIE (N = 51), employing liquid chromatography-mass spectrometry. noted that levels several increased over...
Despite advances in respiratory distress syndrome (RDS) management over the past decade, non-invasive ventilation (NIV) failure is frequent and associated with adverse outcomes. There are insufficient data on of different NIV strategies currently used clinical practice preterm infants.This was a prospective, multicenter, observational study very infants [gestational age (GA) <32 weeks] admitted to neonatal intensive care unit for RDS that required from first 30 min after birth. The primary...
Birth asphyxia is one of the principal causes early neonatal death. In survivors it may evolve to hypoxic-ischaemic encephalopathy and major long-term neurological morbidity. Prolonged intense will lead energy exhaustion in tissues exclusively dependent on aerobic metabolism, such as central nervous system. Energy deficit leads ATP-dependent pumps blockage, with subsequent loss neuronal transmembrane potential. The most sensitive areas brain die due necrosis. more resistant areas,...
El rotavirus (RV) es la causa principal de diarrea infantil grave en todo el mundo e infecta prácticamente a todos los niños primeros 5 años vida, sobre 2 años. Existen dos vacunas atenuadas administración oral frente al RV disponibles nuestro medio que han demostrado ser seguras y eficaces enfermedad. objetivo estas ha sido reproducir historia natural infección proteger enfermedad meses vida. Los recién nacidos prematuros son especialmente vulnerables por RV, no solo tener más riesgo...
Abstract Background Congenital heart disease (CHD) is the most prevalent congenital malformation affecting 1 in 100 newborns. While advances early diagnosis and postnatal management have increased survival CHD children, worrying long-term outcomes, particularly neurodevelopmental disability, emerged as a key prognostic factor counseling of these pregnancies. Methods Eligible participants are women presenting at 20 to < 37 weeks gestation carrying fetus with CHD. Maternal/neonatal...
Home birth is a controversial issue that raises safety concerns for paediatricians and obstetricians. Hospital was the cornerstone to reduce maternal neonatal mortality. This reduction in mortality has resulted considering pregnancy childbirth as safe procedure, which, together with greater social awareness of need humanisation these processes, have led an increase demand home birth. Studies from countries such Australia, Netherlands, United Kingdom show can provide advantages mother...
Abstract Aim To investigate whether increased brain natriuretic propeptide (NT-proBNP) levels at 48 to 72 h of life are associated with the development bronchopulmonary dysplasia (BPD) or death in premature neonates. Methods A retrospective study was performed neonates born before 32 weeks’ gestation birth weight below 1500 grams, whom NT-proBNP determination and echocardiography were life. Associations between combined outcome BPD analyzed using multivariate logistic regression analysis....
Primary cutaneous aspergillosis is rare in premature infants. It requires combined medical and surgical strategies. Liposomal amphotericin B recommended as first-line therapy, but salvage regimens with others antifungal agents, such voriconazole, have been reported. Voriconazole's pharmacodynamics unknown this population. We report a case of severe toxicity to voriconazole preterm patient primary aspergillosis.
Perinatal Palliative Care is a model of care designed to prevent and treat the physical, spiritual, emotional, social needs fetuses newborn infants with life-threatening or life-limiting conditions. The extends infant's family. It delivered by an interdisciplinary team improve quality life from time diagnosis (possibly in utero) into death bereavement (days, months years later). To guarantee access this vulnerable population high palliative care, structured programs protocols need be further...
La escasa evidencia sobre el uso de las transfusiones en neonatología explica limitaciones guías clínicas actuales. A pesar ello, este documento analizamos la más reciente para hacer unas recomendaciones práctica clínica. prevención anemia prematuridad, protocolos y indicaciones restrictivas transfusión, componen mejor estrategia nuestros clínicos. En plaquetas, es preciso valorar riesgo sangrado, integrando situación clínica analítica. Por último, plasma fresco congelado está recomendado...
Objective To evaluate the initial doses of surfactant administered to preterm infants with respiratory distress syndrome. Study Design This is a retrospective cohort study 206 admitted in four level III neonatal intensive care units acute tertiary hospitals Spain between 2013 and 2015. Results The mean dose was 173.9 (37.3) mg/kg, 47.5% received 200 mg/kg ± 10% (180–220 mg/kg), 47% less than 180 (–10%), 5.4% more 220 (+10%). Very (<28 weeks) higher mature infants, but all cases, were...
Apenas conocemos cómo es la asistencia de los recién nacidos (RN) con encefalopatía hipóxico-isquémica (EHI) en hipotermia terapéutica (HT), especialmente si existen protocolos asistenciales, neuromonitorización que se realiza o aproximación al pronóstico neurológico. Este conocimiento permite detectar e implementar áreas mejora asistencial. Estudio transversal 57 hospitales españoles realizaban HT 2015, mediante cuestionario sobre: 1) disponibilidad y recursos tecnológicos; 2) el uso...
Las primeras horas de vida un recién nacido enfermo o prematuro son cruciales para su pronóstico y, por lo tanto, el parto debería acontecer en centro preparado ese grado complejidad. Cuando no se cumple esta condición, debe ser trasladado modo óptimo y seguro al que pueda ofrecerle los cuidados necesarios. La formación, la dotación, organización coordinación del equipo transporte neonatal indispensables garantizar traslado condiciones. Siendo conscientes interés avances actualidad están...
El reconocimiento del dolor y su tratamiento en las unidades de cuidados intensivos neonatales continúa siendo un desafío para los profesionales sanitarios responsables la atención estos niños. Las exposiciones dolorosas repetidas a que se someten muchos pacientes manera rutinaria han demostrado presentar efectos deletéreos corto largo plazo. Los recién nacidos prematuros, especialmente vulnerables, suponen una población alto riesgo. Pese recomendaciones internacionales, el sigue evaluado...