A5054980066- Congenital Heart Disease Studies
- Fetal and Pediatric Neurological Disorders
- Prenatal Screening and Diagnostics
- Cardiovascular Issues in Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Neonatal and fetal brain pathology
- Pregnancy and preeclampsia studies
- Congenital Diaphragmatic Hernia Studies
- Cardiac Arrhythmias and Treatments
- Advanced MRI Techniques and Applications
- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Cardiac Valve Diseases and Treatments
- Tracheal and airway disorders
- Urological Disorders and Treatments
- Congenital Anomalies and Fetal Surgery
- Maternal and fetal healthcare
- Cardiovascular Function and Risk Factors
- Coronary Artery Anomalies
- Birth, Development, and Health
- Genetic Syndromes and Imprinting
- Ectopic Pregnancy Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Congenital heart defects research
- Autopsy Techniques and Outcomes
Hospital Sant Joan de Déu Barcelona
2016-2025
Universitat de Barcelona
2015-2025
Sant Joan de Déu Research Foundation
2025
Institut de Recerca Sant Joan de Déu
2025
Hospital Clínic de Barcelona
2007-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2012-2024
Centre for Biomedical Network Research on Rare Diseases
2012-2022
Instituto de Salud Carlos III
2022
Centro de Investigación Biomédica en Red
2012-2015
Society for Maternal-Fetal Medicine
2013
ABSTRACT Objectives To evaluate the associations between congenital heart disease ( CHD ) and head biometry cerebrovascular blood flow dynamics at time of diagnosis in second trimester pregnancy. Methods This was a study 95 consecutive fetuses diagnosed with . At diagnosis, fetal performed brain perfusion assessed by middle cerebral artery pulsatility index MCA‐PI ), cerebroplacental ratio CPR fractional moving volume FMBV ). The results were compared those normal matched for gestational...
ABSTRACT Objectives Fetuses with congenital heart disease ( CHD ) show evidence of abnormal brain development before birth, which is thought to contribute adverse neurodevelopment during childhood. Our aim was evaluate whether in late pregnancy can be predicted by fetal Doppler, head biometry and the clinical form at time diagnosis. Methods This a prospective cohort study including 58 fetuses , diagnosed 20–24 weeks' gestation, normal control fetuses. At diagnosis, we recorded circumference...
To evaluate, in a cohort of 248 fetuses seen at tertiary referral center, the frequency isolated ventricular septal defects (VSD) among all congenital heart (CHD), association with chromosomal and postnatal anomalies rate spontaneous closure.This was 6-year study on 10,800 women referred for fetal echocardiography, 995 confirmed cases CHD. The prevalence characteristics VSDs were analyzed, including follow-up until 1 year age. Multivariate binary logistic regression analysis performed to...
We evaluated the hypothesis that in fetuses with congenital heart disease (CHD) there is a correlation between expected pattern of utero brain blood supply and severity neurodevelopmental impairment.A total 58 CHD controls underwent Doppler ultrasound fetal MRI at 36-38 weeks. Fetuses were divided into two functional classes: class A an severe reduction oxygenated (left outflow tract obstruction transposition great vessels) B theoretically near-normal or mildly impaired (other CHD). Head...
To determine the longitudinal behavior of fetal biometric measures and cerebroplacental hemodynamics throughout gestation in fetuses with congenital heart disease (CHD).Fetal biometry Doppler (uterine artery (UtA), umbilical (UA) middle cerebral (MCA)) were measured serially a cohort consecutive diagnosed CHD. Evaluations made at various time points, from diagnosis (20-25 weeks) to delivery, least two measurements per fetus that 2 weeks apart. Fetuses classified into three groups according...
Objectives: This study aimed to assess the role of olfactory sulci (OS) in diagnosing CHARGE syndrome among fetuses with major congenital heart defects (CHDs). Methods: We prospectively evaluated OS development diagnosed CHDs from 2017 2021. Neurosonography (NSG) was performed using transabdominal and transvaginal approaches after 30 weeks gestation. assessment conducted trans-frontal coronal plane, classifying their appearance as fully developed, hypoplastic, or absent. Abnormal cases...
<b><i>Objectives:</i></b> We used magnetic resonance spectroscopy (MRS) to evaluate brain metabolic differences in small fetuses near term as compared appropriate for gestational age (AGA) fetuses. <b><i>Study Design:</i></b> 71 (estimated fetal weight <10th centile with normal umbilical artery Doppler sonography) were subclassified late intrauterine growth restriction (IUGR) (n = 50) or (SGA) 21), and 65 AGA IUGR was defined by either...
<b><i>Objective:</i></b> To report the results of fetal cystoscopic laser ablation posterior urethral valves (PUV) in a consecutive series two referral centers. <b><i>Methods:</i></b> Twenty pregnant women with presumptive isolated PUV were treated cystoscopy under local anesthesia. Identification and fulguration by one or several firing-contacts diode attempted. Perinatal long-term outcomes prospectively recorded....
To report on the accuracy of fetal echocardiography in distinction between truncus arteriosus communis (CAT) and pulmonary atresia with ventricular septal defect (PA-VSD) to describe association extracardiac chromosomal anomalies.This was a retrospective study 31 fetuses single arterial trunk overriding VSD nonidentifiable right ventricle outflow tract anterograde flow. Data type cardiac defect, gestational age, characteristics valve, presence additional vascular, abnormalities postnatal...
ABSTRACT Objectives To define the pattern of fetal echocardiographic changes associated with isolated pulmonary valve stenosis (PS) and to correlate findings neonatal outcome need for postnatal valvuloplasty within first 12 months postpartum. Methods This was a prospective cohort study between January 2009 October 2015 16 fetuses PS 48 controls matched by gestational age at ultrasound examination (± 2 weeks) evaluated Fetal Cardiology Unit BCNatal (Barcelona). Standard comprehensive...
<b><i>Objective:</i></b> To evaluate the rate of pulmonary stenosis and functional atresia (PS/PA) in recipient twins prior to fetal surgery for twin-twin transfusion syndrome (TTTS) their pre- postnatal outcomes. <b><i>Methods:</i></b> We carried out a prospective study including 260 cases TTTS. Echocardiography was performed before laser detect presence PS/PA. The outcomes recipients with without PS/PA were compared. need cardiac...
Fetal Heart Quantification (FetalHQ®) is a novel speckle tracking software that permits the study of global and regional ventricular shape function from 2D four-chamber-view loop. The 4D-Spatio Temporal Image Correlation (STIC) modality enables offline analysis optimized perfectly aligned cardiac planes. We aimed to evaluate feasibility reproducibility 4D-STIC echocardiography (STE) using FetalHQ® compare it STE. conducted prospective including 31 low-risk singleton pregnancies between 20 40...
Objective The aim of the study was to evaluate effectiveness intravenous iron versus placebo added standard oral therapy in treatment severe postpartum anaemia. Design A randomised, double‐blind, parallel‐group, placebo‐controlled clinical trial performed a single centre. Setting Hospital Clinic Barcelona, Spain. Population cohort 72 women with anaemia (6.0–8.0 g/dl) treated ferrous sulphate (two tablets 525 mg). Methods Women were randomised receive either sucrose (200 mg/24 hours for two...
To evaluate mitral and tricuspid annular plane systolic excursion (MAPSE TAPSE) in fetuses with twin-to-twin transfusion syndrome (TTTS) before after laser therapy.A prospective study 24 fetal pairs TTTS evaluated h within 48 fetoscopy 13 gestational age-matched normal monochorionic pairs. MAPSE TAPSE were measured an apical or basal four-chamber view by placing the M-mode cursor at lateral valve ring.Mean preoperative (controls 3.6 ± 1.3 mm vs. donors 2.7 0.8 recipients 2.8 0.9; P < 0.001)...
Abstract Background Congenital heart disease (CHD) is the most prevalent congenital malformation affecting 1 in 100 newborns. While advances early diagnosis and postnatal management have increased survival CHD children, worrying long-term outcomes, particularly neurodevelopmental disability, emerged as a key prognostic factor counseling of these pregnancies. Methods Eligible participants are women presenting at 20 to < 37 weeks gestation carrying fetus with CHD. Maternal/neonatal...
To evaluate corpus callosum (CC) size by neurosonography (NSG) in fetuses with an isolated major congenital heart defect (CHD) and explore the association of CC expected pattern in-utero oxygen supply to brain.A total 56 postnatally confirmed CHD gestational-age-matched controls were included. Fetuses stratified into two categories according main cerebral arterial supply: Class A, moderately severely reduced (left outflow tract obstruction transposition great arteries) B, near normal or...
To evaluate the risk of progression to cervical intraepithelial neoplasia (CIN) grade 2 or 3 in women with positive human papillomavirus (HPV) testing and low-grade (low-grade squamous lesions), borderline (atypical cells undetermined significance), no lesions, determine accuracy initial colposcopy predict progression.Women HPV infection atypical cells, normal cytology were recruited grouped according cytologic histologic diagnosis. Exclusion criteria CIN 3, previous cancer infection,...
<b><i>Objectives:</i></b> Firstly, to describe the outcome of a series fetuses with Ebstein’s anomaly (EA) and, secondly, study utility different second-trimester echocardiographic parameters predict fetal and neonatal mortality. <b><i>Methods:</i></b> 39 EA diagnosed between 18 28 weeks gestation were included. Fetal echocardiography included cardiothoracic ratio (CTR); right atrial (RA) area index; displacement tricuspid valve (TV);...
Fetuses with congenital heart disease (CHD) have circulatory changes that may lead to predictable blood flow disturbances affect normal brain development. Hypoxemia and hypoperfusion alter the redox balance leading oxidative stress (OS), can be assessed measuring stable end-products. OS biomarkers (OSB) were measured in amniotic fluid fetuses (n = 41) without CHD 44) analyzed according aortic flow, expected cyanosis after birth, a classification derived from this. Birth head circumference...
Twin-to-twin transfusion syndrome is a serious condition that can affect pregnancies when identical twins share the placenta. In these cases, abnormal placental vessel connections (anastomoses) cause an uneven blood distribution between babies. Ultrasound (US) enormously facilitates assessment of but placenta segmentation still challenging task due to artifacts and high variability in its position, orientation, shape appearance. We propose for first time fully-automated framework achieve...