A5015945265- Congenital Heart Disease Studies
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Cardiac Valve Diseases and Treatments
- HIV Research and Treatment
- Renal and Vascular Pathologies
- BRCA gene mutations in cancer
- Congenital heart defects research
- Tracheal and airway disorders
- Aortic Disease and Treatment Approaches
- Birth, Development, and Health
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Prenatal Screening and Diagnostics
- Pulmonary Hypertension Research and Treatments
- HIV/AIDS drug development and treatment
- Coronary Artery Anomalies
- Cardiac Structural Anomalies and Repair
- Cardiovascular and Diving-Related Complications
- Aortic Thrombus and Embolism
- Cardiac tumors and thrombi
- Assisted Reproductive Technology and Twin Pregnancy
- Pediatric Hepatobiliary Diseases and Treatments
- Cytomegalovirus and herpesvirus research
- Maternal and fetal healthcare
Hospital Son Llatzer
2012-2024
Hospital Universitario Reina Sofía
2020-2023
Universitat Autònoma de Barcelona
2013-2019
Cornell University
2019
Roper Hospital
2018
Good Samaritan Hospital
2018
IrsiCaixa
2014-2017
Society for Maternal-Fetal Medicine
2015-2017
Instituto de Salud Carlos III
2013-2016
Fundación Instituto Valenciano de Oncología
2016
Animal models showed that angiogenesis is related to abnormal heart development. Our objectives were ascertain whether a relationship exists between congenital defects (CHDs) and angiogenic/anti-angiogenic imbalance in maternal foetal blood study the expression of angiogenic factors heart.Maternal cord placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) endoglin (sEng) compared 65 cases CHD 204 normal controls. Angiogenic markers hypoxia measured tissue from 23...
To determine the longitudinal behavior of fetal biometric measures and cerebroplacental hemodynamics throughout gestation in fetuses with congenital heart disease (CHD).Fetal biometry Doppler (uterine artery (UtA), umbilical (UA) middle cerebral (MCA)) were measured serially a cohort consecutive diagnosed CHD. Evaluations made at various time points, from diagnosis (20-25 weeks) to delivery, least two measurements per fetus that 2 weeks apart. Fetuses classified into three groups according...
Recent studies pointed to an intrinsically angiogenic imbalance in CHD the maternal and foetal circulation suggestive of impaired placentation.To assess whether pregnant women with a foetus are at greater risk placenta-related complications.Perinatal results CDH were compared those non-selected population followed up our centre. Multiple pregnancies chromosomal abnormalities excluded from analysis.About 279 foetuses included. Mothers classified three groups according cardiac defect: 104...
SAMHD1 and the CDKN1A (p21) cyclin-dependent kinase inhibitor have been postulated to mediate HIV-1 restriction in CD4+ cells. We shown that p21 affects HIV replication through its effect on SAMHD1. Thus, we aimed at evaluating expression of different HIV+ phenotypic groups. evaluated mRNA T cells from individuals including elite controllers (n = 12), who control without need for antiretroviral treatment, viraemic progressors 10) seronegative healthy donors 14). Immunological variables were...
Forty percent of Down syndrome (DS) fetuses have congenital heart defects (CHD). An abnormal angiogenic environment has been described in euploid with CHD. However, the underlying pathophysiologic pathway that contributes to CHD DS remains unknown. The objective was compare expression factors and chronic hypoxia genes tissue from without CHD.The gene profile determined by real-time PCR quantification 33 DS, 23 control fetuses.Angiogenic mRNA significantly increased group compared controls...
Abstract Background Congenital heart disease (CHD) is the most prevalent congenital malformation affecting 1 in 100 newborns. While advances early diagnosis and postnatal management have increased survival CHD children, worrying long-term outcomes, particularly neurodevelopmental disability, emerged as a key prognostic factor counseling of these pregnancies. Methods Eligible participants are women presenting at 20 to < 37 weeks gestation carrying fetus with CHD. Maternal/neonatal...
Introduction Pre-eclampsia affects ~5%–7% of pregnancies. Although improved obstetric care has significantly diminished its associated maternal mortality, it remains a leading cause morbidity and mortality in the world. Term pre-eclampsia accounts for 70% all cases large proportion maternal–fetal related to this condition. Unlike preterm pre-eclampsia, prediction prevention term remain unsolved. Previously proposed approaches are based on combined third-trimester screening and/or...
Nonvisualization of the fetal gallbladder has been associated with benign conditions such as isolated agenesis or severe diseases biliary atresia (BA). Recently, gamma-glutamyl transpeptidase (GGTP) blood levels were reported useful after 22 weeks.To determine contribution GGTP weeks, based on 2 cases. Case 1: 20+4-week secundipara, subcutaneous edema and pleural effusion. At 24+4 could not be visualized. Progressive hydrops deterioration was observed. 32+2-week magnetic resonance imaging...
To ascertain whether abnormalities in neonatal head circumference and/or body weight are associated with levels of angiogenic/antiangiogenic factors the maternal and cord blood pregnancies a congenital heart defect (CHD) to assess specific type CHD influences this association.
Abstract Background The role of right ventricular-pulmonary arterial coupling, non-invasively evaluated by means the tricuspid annular plane systolic excursion (TAPSE) and pulmonary artery pressure (PASP) ratio in prognostic assessment regurgitation (TR) has been studied only selected populations mainly for all-cause mortality. Purpose To investigate value TAPSE/PASP predicting combined end-point mortality heart failure (HF) admission follow-up a broad population patients with severe TR, to...
To ascertain the relation between an anti-angiogenic status during fetal life and cardiac function endothelial disease in a cohort of growth restriction (FGR) children at 3–4 years age. 40 diagnosed FGR followed until 3–5 age were included study. 25 controls matched for gestational delivery included. At delivery, maternal perinatal outcome cord blood samples obtained. SFlt1 PlGF measured blood. evaluated: anthropometric data, metabolic parameters (total cholesterol, LDL, HDL, TG, Apoprotein...
Congenitally corrected transpositions of great arteries (ccTGA) is an uncommon cardiac defect. Clinical presentation can be uncertain and will depend on associated lesions. The aim this study to analyse the prenatal diagnosis long-term postnatal outcome ccTGA. It a retrospective observational 53 cases ccTGA diagnosed in our centre from 1993 2012. In 13 (24%) was prenatally. Median gestational age 20.6 weeks. Among fetal cases, Isolated present 6 patients (46%), 2 had ventricular septal...
Animal models and human data showed that abnormal angiogenesis is associated with heart development. Developmental processes, including angiogenesis, cardiogenesis placentation are regulated by O2 levels. Our objectives were to evaluate the expression of angiogenic factors their relation hypoxia markers in fetal congenital defects (CHD) euploid Down's syndrome fetuses. Angiogenic (VEGF, PlGF sFlt1) (HIF-1α, HIF-2α, HO-1 SOD1) measured tissue from 23 CHD, 15 Down fetus 8 controls undergoing...
Prenatal diagnosis of coarctation the aorta (CoAo) remains a challenge. In order to predict those who will need surgical postnatal approach some sonographic features have been described. We analyzed outcome all cases with cardiac disproportion in our center using these markers. Between 2005 and 2014, 95 consecutive fetuses were diagnosed isolated ventricular and/or great arterial disproportion. (3 underwent TOP, 1 patient incomplete follow-up). The following analyzed: Isthmal diameter...
To determine the longitudinal behaviour of fetal biometries and cerebrovascular hemodynamics throughout gestation in fetuses with congenital heart disease (CHD). Fetal Doppler (uterine artery (UtA), umbilical (UA) middle cerebral (MCA)) were serially performed a cohort consecutive diagnosed CHD. Evaluations at various points from diagnosis (< 25 weeks gestation) to delivery, least 2 measurements for each fetus, 4 apart. All parameters transformed into z-scores. A linear mixed model analyse...
Isolated fetal major heart defects maternal serum PlGF at 11–13 weeks of gestation is decreased, suggesting impaired placental angiogenesis. Our aim was to assess whether pregnant women carrying a fetus with CHD are greater risk related complications. Retrospective study in from 2003 2014, focusing perinatal outcome and The incidence complications such as preeclampsia (PE), eclampsia, HELLP (hemolysis, elevated liver enzymes low platelets) syndrome, stillbirth intrauterine growth restriction...
Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): Andalusian Society Cardiology Introduction A new classification severe tricuspid regurgitation (TR) has recently been described that distinguishes three subgroups: severe, massive and torrential. Our objective was to analyse the prevalence categories, describe their baseline characteristics according severity group assess impact on prognosis in a large series patients with TR tertiary care hospital our...
Abstract Background Three scores have been published in 2022 for assessing prognosis of patients with tricuspid regurgitation (TR): the TRI-SCORE, and those reported by Hochstadt Wang. All them shown to be useful prediction mortality follow-up. However only one has externally validated, their comparative performance is unknown, discriminative ability broader outcomes not investigated. Purpose To perform an external validation available predicting combined end-point heart failure (HF)...
Determine the predictive ability of placenta accreta in prenatal ultrasound diagnosis our general population pregnant women. A prospective study 8999 women during period Jan 08 to Aug 11. We searched for suspicious sonographic signs accreta: numerous vascular lacunae, absent lower uterine segment between bladder and placenta, turbulent or complicated blood flow at uteroplacental interface with particular attention cases previous cesarean section / previa. There were 7 accreta, 6 diagnosed...
Abstract This abstract was not presented at the symposium.
Abstract Background: The testing of hereditary breast and ovarian cancer (HBOC) patients for BRCA1/2 only was established years ago to identify with clinically actionable variants limit the economic burden. However, cost genetic has plummeted, number cancer-risk genes management guidelines expanded. We created a community-based registry test all patients. A primary objective this included accruing comparing who did not meet NCCN determining if providing comprehensive multi-gene panel yields...