A5010481483- Pregnancy and preeclampsia studies
- Rheumatoid Arthritis Research and Therapies
- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Lysosomal Storage Disorders Research
- Heavy Metal Exposure and Toxicity
- Autoimmune and Inflammatory Disorders Research
- Studies on Chitinases and Chitosanases
- Aluminum toxicity and tolerance in plants and animals
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Nutrition and Health in Aging
- Systemic Lupus Erythematosus Research
- Congenital Heart Disease Studies
- Trace Elements in Health
- Streptococcal Infections and Treatments
- Testicular diseases and treatments
- Urologic and reproductive health conditions
- Metabolism and Genetic Disorders
- Allergic Rhinitis and Sensitization
- Sepsis Diagnosis and Treatment
- Assisted Reproductive Technology and Twin Pregnancy
- Cardiovascular Issues in Pregnancy
- Neonatal and Maternal Infections
Hôpital de Sion
2024
Hospital Universitario Virgen Macarena
2014-2024
Duke University
2024
Universidad de Panamá
2024
Centre for Biomedical Network Research on Rare Diseases
2007-2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2023
Karolinska Institutet
2021
Instituto de Salud Carlos III
2007-2018
CIBBIM-Nanomedicine
2011-2018
Vall d'Hebron Hospital Universitari
1994-2016
Abstract Objectives To investigate potential differences in the prediction of early‐ vs. late‐onset pre‐eclampsia and/or intrauterine growth restriction (PE/IUGR) by second‐trimester uterine artery Doppler examination, and measurement maternal serum placental factor (PlGF) soluble fms‐like tyrosine kinase 1 (sFlt1). Methods Uterine mean pulsatility index (PI) PlGF sFlt1 levels were measured at 24 weeks gestation 76 healthy pregnant women 38 cases PE/IUGR, which 19 defined as early onset...
Animal models showed that angiogenesis is related to abnormal heart development. Our objectives were ascertain whether a relationship exists between congenital defects (CHDs) and angiogenic/anti-angiogenic imbalance in maternal foetal blood study the expression of angiogenic factors heart.Maternal cord placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) endoglin (sEng) compared 65 cases CHD 204 normal controls. Angiogenic markers hypoxia measured tissue from 23...
To develop optimal first-trimester algorithms for the prediction of early and late fetal growth restriction (FGR).This was a prospective cohort study singleton pregnancies undergoing screening. FGR defined as an ultrasound estimated weight < 10(th) percentile plus Doppler abnormalities or birth 3(rd) percentile. Logistic regression-based predictive models were developed predicting (cut-off: delivery at 34 weeks). The model included a-priori risk (maternal characteristics), mean arterial...
We evaluated the clinical characteristics found in 21 children who showed allergic reactions upon incidental inhalation offish odors or fumes, from 197 diagnosed with IgE‐mediated fish hypersensitivity. Allergic to via ingestion began most patients (86%) within first 24 months of life. The vast majority (19/21) cutaneous symptoms, either alone or, less frequently, associated other manifestations. Hake and flounder were species frequently implicated eliciting manifestations ingestion. After...
Background: Chitinase 3-like 1 (CHI3L1) is upregulated in a wide variety of inflammatory conditions. Recent studies have pointed to role CHI3L1 multiple sclerosis (MS) pathogenesis. Objective: The objective this study was investigate the plasma MS clinical course and disease activity evaluate effect interferon-beta (IFNβ) treatment on protein levels. Methods: Plasma levels were determined by ELISA 57 healthy controls (HC), 220 untreated patients [66 primary progressive (PPMS), 30 secondary...
To perform a comprehensive assessment of the placental aging process in small term fetuses classified as being small-for-gestational age (SGA) or having fetal growth restriction (FGR) through analysis senescence and apoptosis markers.This was prospective nested case-control study singleton pregnancies delivered at term, including 21 control with normally grown 36 fetus SGA (birth weight between 3rd 9th percentiles normal fetoplacental Doppler; n = 18) FGR < percentile and/or abnormal...
To assess the ability of integrated first-trimester screening, combining maternal characteristics and biophysical biochemical markers, to predict delivery a small-for-gestational-age (SGA) neonate, compare this with its fetal growth restriction (FGR).This was prospective cohort study singleton pregnancies undergoing routine screening. SGA defined as birth weight (BW) < 10th percentile FGR an ultrasound estimated plus Doppler abnormalities, or BW 3rd percentile. Logistic regression-based...
Aim : To investigate whether the serum levels of interleukin‐1β, 6, 8, tumour necrosis factor‐α and soluble receptor IL‐2 are useful in diagnosis neonatal sepsis, their diagnostic power is increased when combination with classical markers such as C‐reactive protein white blood cell count. Methods Blood samples were collected at admission from 40 neonates suspected infection. Patients included different groups according to bacteriological laboratory results: Group I consisted 20 newborns...
Mirror syndrome is a rare condition that involves fetal hydrops, placentomegaly and severe maternal edema. The pathogenesis of this mimics endothelial dysfunction observed in pre-eclampsia. We report case mirror caused by bilateral hydrothorax resolved after intrauterine pleuroamniotic shunt placement. At the time clinical manifestation there was an antiangiogenic state similar to seen pre-eclampsia, which treatment. Our findings suggest broad spectrum pathological conditions induces state.
Moreno A, Domínguez C, Ballabriga A. Aluminium in the neonate related to parenteral nutrition. Acta Pædiatr 1994;83:25–9. Stockholm. ISSN 0803–5253 Sources of aluminium loading and exposure preterm full‐term newborns were studied. Parenteral nutrition solutions main source representing 88.7% total intake. Blood urine levels followed over a 28‐day period group 26 9 term infants while receiving (duration 15.6 ± 8.7 days) later when being formula fed. Urine up 13 weeks subgroup neonates. Serum...
Niemann-Pick disease (NPD) types A and B are autosomal, recessively inherited, lysosomal storage disorders caused by deficient activity of acid sphingomyelinase (E.C. 3.1.4.12) because mutations in the sphingomyelin phosphodiesterase-1 (SMPD1) gene. Here, we present molecular analysis clinical characteristics 15 NPD type patients. Sequencing SMDP1 gene revealed eight previously described seven novel including four missense [c.682T>C (p.Cys228Arg), c.1159T>C (p.Cys387Arg), c.1474G>A...
To assess the relationship between longitudinal changes in placental Doppler indices and maternal circulating angiogenic factors first half of pregnancy delivery a small-for-gestational-age (SGA) neonate, ascertain whether evaluation these variables improves prediction achieved by second-trimester cross-sectional evaluation.From prospective cohort unselected singleton pregnancies undergoing first-trimester screening for aneuploidy, 138 were included this study. Of these, 46 complicated SGA...
The risk of pre-eclampsia (PE) increases in twin pregnancies, especially when assisted reproduction technologies (ART) are used. aim this study was to assess angiogenic/anti-angiogenic factors maternal serum the first trimester pregnancies and establish if mode conception influences angiogenic status. This prospective enrolled women with (n = 61) singleton 50) pregnancies. Dichorionic were divided into two groups according their conception. Singleton used as control group. Soluble fms-like...
Juvenile rheumatoid arthritis (JRA) is the most commonly diagnosed rheumatic disease in children and may represent not a single disease, but rather syndrome of diverse aetiologies which inflammation an exceedingly complex process. Oxidative free radical production at sites contributes to tissue damage could also play significant role pathogenesis JRA. The aim this study was evaluate antioxidant status lipid peroxidation parameters related clinical form Plasma malondialdehyde hydroperoxide...
Antioxidant depletion and increased free radical production by inflammatory cells have been described in cystic fibrosis (CF) patients. To evaluate oxidative damage intensity, we measured plasma concentrations of malondialdehyde, hydroperoxides protein carbon groups as markers injury to lipids proteins a group 101 CF patients acute exacerbation, 43-112 controls. Moreover, estimated antioxidant function measuring activities erythrocyte superoxide dismutase, glutathione reductase vitamin E...
Añíbarro B, Domínguez C, Díaz JM, Martín MF, García‐Ara MC, Boyano MT, Ojeda JA. Apple‐dependent exercise‐induced anaphylaxis.
Abstract Oxidative stress has been implicated as a mechanism underlying hyperglycaemia‐associated cellular damage and could play role in the development of diabetes‐related complications. This study aimed to evaluate significance changes oxidant–antioxidant status 176 child adolescent diabetic patients at clinical onset, during disease progression when early microvascular complications appeared. Indicative lipid protein oxidation markers antioxidant defence activity were measured plasma...
SummaryA double-blind, placebo-controlled trial was carried out to assess the effectiveness of a new synthetic bioflavonoid, hidrosmin, in patients with chronic venous insufficiency lower limbs. Fifty-seven patients, showing varicose veins and ankle swelling suffering from local pain heaviness legs, were allocated at random receive treatment for 45 days 1 capsule 3-times daily either 200 mg hidrosmin (30 patients) or placebo (27 patients). Pain heavy legs assessed using rating scales; by...
Con el objetivo de desarrollar una campaña publicitaria para promover buenas prácticas salud y cuidado del ambiente en las comunidades rurales semirurales corregimiento Sorá, se realizò investigación determinar los medios comunicación utilizados por la población mantenerse informada, lo cual proporciona datos relevantes definir estrategia adecuada a realidad región Resultados componente Comunicación, estudio multidisciplinario que unió diversas disciplinas Universidad Panamá vinculó...