A5011728649- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Airway Management and Intubation Techniques
- Respiratory Support and Mechanisms
- Neonatal and fetal brain pathology
- Neonatal Health and Biochemistry
- Non-Invasive Vital Sign Monitoring
- Infant Development and Preterm Care
- Metabolism and Genetic Disorders
- Congenital Diaphragmatic Hernia Studies
- Foot and Ankle Surgery
- Congenital Heart Disease Studies
- Hemodynamic Monitoring and Therapy
- Acute Kidney Injury Research
- Cystic Fibrosis Research Advances
- Retinopathy of Prematurity Studies
- Tracheal and airway disorders
- Cardiovascular Conditions and Treatments
- Anesthesia and Sedative Agents
- Eicosanoids and Hypertension Pharmacology
- Cerebral Palsy and Movement Disorders
- Wireless Body Area Networks
- Nosocomial Infections in ICU
- Pharmacology and Obesity Treatment
- Lower Extremity Biomechanics and Pathologies
University Children's Hospital Tübingen
2008-2025
Johannes Gutenberg University Mainz
2024
Universitätsklinikum Tübingen
2023
University of Tübingen
2007-2021
<h3>Importance</h3> Red blood cell transfusions are commonly administered to infants weighing less than 1000 g at birth. Evidence-based transfusion thresholds have not been established. Previous studies suggested higher rates of cognitive impairment with restrictive thresholds. <h3>Objective</h3> To compare the effect liberal vs red strategies on death or disability. <h3>Design, Setting, and Participants</h3> Randomized clinical trial conducted in 36 level III/IV neonatal intensive care...
Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE Europe even more regions with lower level perinatal care. The only established therapy improve outcome these therapeutic hypothermia. Allopurinol xanthine oxidase inhibitor that reduces the production oxygen radicals as superoxide, which contributes secondary energy failure apoptosis neurons glial cells after...
Abstract Background Despite therapeutic hypothermia (TH) and neonatal intensive care, 45–50% of children affected by moderate-to-severe hypoxic-ischemic encephalopathy (HIE) die or suffer from long-term neurodevelopmental impairment. Additional neuroprotective therapies are sought, besides TH, to further improve the outcome infants. Allopurinol — a xanthine oxidase inhibitor reduced production oxygen radicals subsequent brain damage in pre-clinical preliminary human studies cerebral ischemia...
Abstract Background Most extremely low gestational age neonates (ELGANS, postmenstrual at birth (PMA) < 28 completed weeks) require supplemental oxygen and experience frequent intermittent hypoxemic hyperoxemic episodes. Hypoxemic episodes exposure to inadequately high concentrations of are associated with an increased risk retinopathy prematurity (ROP), chronic lung disease (BPD), necrotizing enterocolitis (NEC), neurodevelopmental impairment (NDI), death beyond 36 weeks PMA. Closed-loop...
The European guideline for treatment of respiratory distress syndrome recommends less invasive surfactant administration (LISA) as the preferred method in spontaneously breathing preterm infants. However, there is limited evidence on practical aspects such sedation and catheter types, leading to considerable variability between centers.
Abstract Background Adequate intake of choline is essential for growth and homeostasis, but its supply does often not meet requirements. Choline deficiency decreases phosphatidylcholine (PC) betaine synthesis, resulting in organ pathology, especially liver, lung, brain. This particular clinical importance preterm infants cystic fibrosis patients. We compared four different supplements their impact on plasma concentration kinetics choline, as a methyl donor trimethylamine oxide (TMAO) marker...
The aim of this study was to provide detailed information on rationales, calculations, and results common methods used quantify reproducibility in plantar pressure variables. Recreational runners ( N = 95) performed multiple barefoot running trials a laboratory setup, variables were analyzed nine distinct subareas the foot. Reproducibility assessed by calculating intraclass correlation coefficients (ICC) root mean square error (RMSE). Intraclass ranged from 0.58 0.99, depending respective...
Allopurinol, an xanthine oxidase (XO) inhibitor, is a promising intervention that may provide neuroprotection for neonates with hypoxic-ischemic encephalopathy (HIE). Currently, double-blind, placebo-controlled study (ALBINO, NCT03162653) investigating the neuroprotective effect of allopurinol in HIE neonates.The aim current was to establish pharmacokinetics (PK) and oxypurinol, pharmacodynamics (PD) both compounds on hypoxanthine, xanthine, uric acid neonates. The dosage used this...
Objective In extremely preterm infants, different target ranges for pulse oximeter saturation (SpO 2 ) may affect mortality and morbidity. Thus, the impact of technical changes potentially affecting measurements should be assessed. We studied SpO readings from sensors systematic deviations. Design Single-centre, randomised, triple crossover study. Setting Tertiary neonatal intensive care unit. Patients 24 born at <32 weeks’ gestation, with current weight <1500 g without right-to-left...
Recent studies indicate an increasing use of less invasive surfactant administration. Different techniques have been shown with distinct risks and benefits. The aim this study was to develop a new method that simplifies procedure.An applicator developed tested on manikin make tracheal application easier faster.A device for oral administration catheter into the trachea developed. After refining, it by 9 neonatologists manikin. primary feasibility, which defined as successful intubation within...
Background Less-invasive surfactant administration (LISA) is increasingly used. We investigated the feasibility of a new LISA-device (Neofact®) in neonates. Design Prospective observational pilot study with open-label LISA two tertiary neonatal intensive care units. Patients 20 infants gestational age ≥26+0/7 weeks and an indication for (Respiratory Severity Score (RSS)≥5 or fraction inspired oxygen (FiO 2 ) ≥0.30). Infants respiratory tract malformations unavailability instructed...
Introduction Delivering surfactant via thin catheters (minimal-invasive therapy (MIST); less invasive administration (LISA)) has become a common procedure. However, the effect of tracheal obstruction caused by different sizes on resistance in extremely low gestational age newborns (ELGANs) is unknown. Methods To investigate size 3.5, 5 and 6 French airway ELGANs 23–28 weeks during LISA, we performed calculations based Hagen-Poiseuille's law compared these with clinically physically more...
Objective The ALBINO Trial ( NCT03162653 ) investigates effects of very early postnatal allopurinol on neurocognitive outcome following perinatal asphyxia where prenatal informed consent (IC) is impossible. Ethically and legally, waiver and/or deferred (DC) acceptable in such an emergency. Short oral/two-step (SOC, brief information oral followed by IC) has recently been investigated. Methods Mixed-methods analysis parental opinions DC versus SOC the context neonatal a survey at two German...
Therapeutic hypothermia (TH) is an established intervention to improve the outcome of neonates with moderate-to-severe hypoxic-ischemic encephalopathy resulting from perinatal asphyxia. Despite this beneficial effect, TH may further affect drug elimination pathways such as glomerular filtration rate.
Aim Data on the depth of nasal intubation in neonates are rare, although this is preferred route some countries. Therefore, recommendations optimal depths based gestational age (GA) and weight desirable. Methods We determined distances between middle thoracic vertebrae 2 (T2) tip endotracheal tube 116 X-rays from nasally intubated neonates. The (tip to nostril distance) that was documented digital patient’s file then corrected for distance reach an insertion depth. Results were plotted...
Less-invasive surfactant administration (LISA) under continuous positive airway pressure is increasingly used for the treatment of neonatal respiratory distress. Different procedures are described, but data on optimal catheter insertion depth sparse.To generate recommending an in LISA.We examined 112 anterior-posterior chest X-rays from intubated infants and determined carina's vertebral projection, whenever possible. After that, distances between middle cervical vertebra 4 (C4) thoracic 2...
Previously, we developed a pharmacokinetic-pharmacodynamic model of allopurinol, oxypurinol, and biomarkers, hypoxanthine, xanthine, uric acid, in neonates with hypoxic-ischemic encephalopathy, which high initial biomarker levels were observed suggesting an impact hypoxia. However, the full pharmacodynamics could not be elucidated our previous study. The current study included additional data from ALBINO (NCT03162653) placebo group, aiming to characterize dynamics acid encephalopathy....