A5103896041- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Vascular Tumors and Angiosarcomas
- Bone Tumor Diagnosis and Treatments
- Childhood Cancer Survivors' Quality of Life
- Lymphoma Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Testicular diseases and treatments
- Surgical site infection prevention
- Tumors and Oncological Cases
- Cancer, Hypoxia, and Metabolism
- Renal and related cancers
- Neurofibromatosis and Schwannoma Cases
- Orthopedic Infections and Treatments
- Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Acute Lymphoblastic Leukemia research
- Virus-based gene therapy research
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Management of metastatic bone disease
Meyer Children's Hospital
2016-2025
Associazione Italiana Ematologia Oncologia Pediatrica
2020-2022
University of Florence
2000-2020
Azienda Ospedaliero-Universitaria Careggi
2018
Istituto Ortopedico Rizzoli
2012
Bambino Gesù Children's Hospital
2001
We compared two chemotherapy regimens that included methotrexate (MTX), cisplatin (CDP), and doxorubicin (ADM) with or without ifosfamide (IFO) in patients nonmetastatic osteosarcoma of the extremity.Patients age ≤ 40 years randomly received same cumulative doses drugs (ADM 420 mg/m(2), MTX 120 g/m(2), CDP 600 IFO 30 g/m(2)) but different durations (arm A, 44 weeks; arm B, 34 weeks). was given postoperatively when pathologic response to MTX-CDP-ADM poor A) primary phase B). End points study...
PURPOSE: To report on the treatment of patients with newly diagnosed neuroblastoma presenting spinal cord compression (SCC). PATIENTS AND METHODS: Of 1,462 children registered between 1979 and 1998, 76 (5.2%) presented signs/symptoms SCC, including motor deficit in 75 (mild 43, moderate 22, severe [ie, paraplegia] 10), pain 47, sphincteric 30, sensory loss 11. Treatment SCC consisted radiotherapy 11 patients, laminectomy 32, chemotherapy 33. Laminectomy was more frequently performed cases...
Patients with osteosarcoma and Ewing sarcoma have achieved longer survival over the past decades, but late side effects of chemotherapy radiotherapy become important concerns.The authors reviewed all patients localized or who had been enrolled in Italian Sarcoma Group neoadjuvant protocols from 1983 through 2006. Data were updated December 2010 to determine 3 endpoints: incidence a secondary primary cancer (designated as "second malignant neoplasm" [SMN]), infertility, cardiotoxicity.Data...
Background Post‐relapse survival (PRS) was evaluated in patients with Ewing sarcoma (EWS) enrolled chemotherapy protocols based on the use of high‐dose busulfan and melfalan (HDT) as a first‐line consolidation treatment high‐risk patients. Procedure EWS ISG/SSG III IV trials who relapsed after complete remission were included analysis. At recurrence, ifosfamide foreseen, responded but had not received HDT underwent therapy HDT. Results Data from 107 Median time to recurrence (RFI) 18 months,...
ABSTRACT Background Several studies have shown that the intensity of treatment in Ewing sarcoma has an impact on outcome. The present trial tested non‐inferiority intensive, shorter, induction chemotherapy (25 weeks total time) compared to standard (37 weeks) non‐metastatic (ES) at onset. Procedure This national, multicenter, parallel, randomized, controlled, open‐label, non‐inferiority, phase III was conducted 14 specialized hospitals Italy. Patients aged 2‐40 years with newly diagnosed...
Objective: Gonadal dysfunction is a major late complication after cancer diagnosis and treatment. We aimed to study the prevalence of premature ovarian insufficiency (POI) potential reduction reserve in cohort adolescent young adult (AYA) patients undergoing treatments, evaluating function markers. also analyze how these markers are related each other treatment-related risk factors. Methods: performed retrospective study, including all female AYA treatment during childhood or adolescence who...
Background According to retrospective osteosarcoma series, ABCB1/P‐glycoprotein (Pgp) overexpression predicts for poor outcomes. A prospective trial assess a risk‐adapted treatment strategy using mifamurtide in Pgp+ patients was performed. Methods This phase 2, multicenter, uncontrolled including 40 years old or younger with nonmetastatic extremity high‐grade stratified according Pgp expression. All received high‐dose methotrexate, doxorubicin, and cisplatin (MAP) preoperatively. In...
(1) Background: We aim to address the following questions. What was complication rate of vascularized fibula graft (VFG) combined with massive allograft in patients treated joint-sparing resection around knee for a high-grade osteosarcoma? long-term survivorship VFG free from revision and removal? were functional results as assessed by Musculoskeletal Tumor Society (MSTS) score? (2) Methods: 39 our unit osteosarcoma intercalary reconstruction included; 26 underwent tibial resection, while 13...
Based on the results of ISG/OS-1 study, MAP regimen (methotrexate [MTX], doxorubicin [ADM] and cisplatin [CDP] with addition ifosfamide [IFO] in poor-responder patients) was investigated patients nonmetastatic osteosarcoma extremity (ISG/OS-Oss study).Compared study (cumulative doses: ADM 420 mg/m(2), MTX 120 g/m(2), CDP 600 IFO 30 g/m(2)), ISG/OS-Oss reduced number cycles from 10 to 5 dose: 60 g/m(2)) order diminish treatment duration toxicity.From January 2007 June 2011, 171 (median age 16...
Background Symptoms of epidural compression (SEC) in children with neuroblastoma (particularly infants) may be misinterpreted, leading to delay diagnosis. Patients and Methods Clinical, imaging follow‐up data 34 infants SEC diagnosed between 2000 2011 at Italian AIEOP centers were retrieved reviewed. Results Median age initial was 104 days (IQR 47–234). Main symptoms included motor deficit (85.3%), pain (38.2%), bladder bowel dysfunctions (20.6% each). In the symptom‐diagnosis interval...
Rhabdomyosarcoma is a soft tissue malignant musculoskeletal tumor frequent in children. Biliary duct localization extremely rare, but it the most common cause of obstructive jaundice pediatric patients.This report describes series 10 patients under 18 years age with biliary tract rhabdomyosarcoma who were enrolled, from 1979 to 2004, 3 consecutive Italian cooperative protocols that had been drawn up by Soft Tissue Sarcoma Committee Associazione Italiana Ematologia Oncologia Pediatrica...
Sarcomas that arise from the scapula or periscapular soft tissues often require a total scapulectomy. This implies large complex tissue defect needs adequate reconstruction of both bone and tissue. Although various methods have been developed, no optimal procedure has emerged. Postoperative complications are common functional recovery is not always satisfactory. study aims to present new surgical technique combines custom-made scapular prosthesis with latissimus dorsi flap. Two patients...
A newborn with unresectable kaposiform hemangioendothelioma associated Kasabach Merritt phenomenon, unresponsive to vincristine and prednisone, received second‐line treatment propranolol at a dose of 2 mg/kg/day, starting months life continued for 13 months. There was only slight reduction in tumor mass, but measurement levels showed extremely low plasma concentrations. The progressively increased 3.5 leading substantial increase clinically relevant reduction. This case highlights the...
Spirituality is a fundamental aspect of the psychological well-being adolescents with cancer. This study reports on survey conducted at pediatric oncology centers in Italy and Spain to examine situation concerning provision spiritual support.An ad hoc questionnaire was distributed including multiple-choice questions whether or not support available; counselor's role; how often counselor visited unit; type training this person had received.A service available 24 26 responding 34/36 Spain. The...
Abstract Background Treatment strategies for Retinoblastoma (RB), the most common primary intraocular tumor in children, have evolved over past few decades and chemoreduction is currently popular treatment strategy. Despite success, systemic chemotherapeutic has relevant toxicity, especially pediatric population. Antiangiogenic therapy thus been proposed as a valuable alternative malignancies, particolar RB. Indeed, it shown that vessel density correlates with both local invasive growth...
High-sensitivity immunocytochemistry was used to evaluate the relative frequency of neuroblastoma cells in bone marrow and peripheral blood patients with (NB). A total 51 concomitant paired samples (102 total) from 35 NB (age 4 months-31 years; stage 29 IV, III, 2 IVS; 14 at diagnosis, 18 relapse, 12 during treatment, 7 off-therapy) were analyzed. Cytospins containing up 106 each prepared using mononuclear cell (MNC) fraction. For immunocytologic staining, a primary mouse monoclonal anti-GD2...
Influence of age and sex on chemotherapy-related toxicity was evaluated in children (3–9 years), adolescents (10–17 adults (up to 40 years) with localized Ewing sarcoma (ES) enrolled the ISG/SSG III protocol. Treatment based vincristine, doxorubicin, cyclophosphamide, ifosfamide, dactinomycin, etoposide. High-dose chemotherapy busulfan melphalan given poor responder patients. The analysis 2191 courses standard 230 A lower risk G4 leukopenia thrombocytopenia, hospitalization, febrile...
Osteosarcoma (OS) is the most common primary malignancy of bone, highly aggressive and metastasizing, it mainly affects children adolescents. The current standard care for OS a combination surgery chemotherapy. However, these treatment options are not always successful, especially in cases metastatic or recurrent osteosarcomas. For this reason, research into new therapeutic strategies currently underway, immunotherapies have received considerable attention. Mifamurtide stands out among...