A5003857662- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cardiac tumors and thrombi
- Asthma and respiratory diseases
- Bone Tumor Diagnosis and Treatments
- Allergic Rhinitis and Sensitization
- Lymphoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Respiratory and Cough-Related Research
- Genetic factors in colorectal cancer
- Electron Spin Resonance Studies
- Colorectal and Anal Carcinomas
- Health Systems, Economic Evaluations, Quality of Life
- Hematological disorders and diagnostics
- CAR-T cell therapy research
- Lung Cancer Treatments and Mutations
- Neuroblastoma Research and Treatments
- Testicular diseases and treatments
- Neurofibromatosis and Schwannoma Cases
- Electrochemical Analysis and Applications
- Olfactory and Sensory Function Studies
- Dermatology and Skin Diseases
- Ethics in Clinical Research
- Mast cells and histamine
- Cholangiocarcinoma and Gallbladder Cancer Studies
Istituto Ortopedico Rizzoli
2013-2022
Italian Sarcoma Group
2016-2022
Candiolo Cancer Institute
2020
Seattle University
2019
Boston University
2019
University of Bologna
1994-2003
University of Milan
1994-1995
Ospedale Maggiore
1995
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
1995
University of Verona
1992
To determine whether the administration of histology-tailored neoadjuvant chemotherapy (HT) was superior to standard anthracycline plus ifosfamide (A+I) in high-risk soft tissue sarcoma (STS) an extremity or trunk wall.This a randomized, open-label, phase III trial. Patients had localized STS (grade 3; size, ≥ 5 cm) wall, belonging one following five histologic subtypes: high-grade myxoid liposarcoma (HG-MLPS); leiomyosarcoma (LMS), synovial (SS), malignant peripheral nerve sheath tumor...
Few new compounds are available for relapsed osteosarcoma. We retrospectively evaluated the activity of gemcitabine (G) plus docetaxel (D) in patients with high-grade osteosarcoma and spindle cell sarcoma bone (HGS). Patients receiving G 900 mg/m2 d 1, 8; D 75 8, every 21 days were eligible. Primary end-point: progression-free survival (PFS) at 4 months; secondary overall (OS) response rate. Fifty-one included, a median age 17 years (8–71), 26 (51 %) pediatric patients. GD line treatment:...
The value of neoadjuvant chemotherapy in soft tissue sarcoma (STS) is not completely understood. This study investigated the benefit according to prognostic stratification based on Sarculator nomogram for STS.This analyzed data from ISG-STS 1001, a randomized that tested 3 cycles anthracycline plus ifosfamide (AI) or histology-tailored (HT) adult patients with STS. 10-year predicted overall survival (pr-OS) was estimated and stratified into higher (10-year pr-OS < 60%) lower risk subgroups ≥...
The histological response to neoadjuvant chemotherapy is an important prognostic factor in patients with osteosarcoma (OS) and Ewing sarcoma (EWS). aim of this study was assess baseline primary tumour FDG uptake on PET/CT, serum values alkaline phosphatase (ALP) lactate dehydrogenase (LDH), establish whether these factors are correlated necrosis prognosis. Patients treated between 2009 2014 for localized EWS OS, who underwent PET/CT as part their staging work-up, were included. relationships...
Background: Data on temozolomide (TEM) and irinotecan (IRI) activity in recurrent Ewing sarcoma (EWS), especially adult patients, are limited.Methods: Patients receiving TEM 100 mg/m2/day oral, IRI 40 intravenous, days 1–5, every 21 days, were included this multi-institutional retrospective study. Disease control rate (DCR) [overall response (ORR) [complete (CR) + partial (PR)] stable disease (SD)], 6-months progression-free survival (6-mos PFS) 1-year overall (OS) assessed.Results: The...
Background According to retrospective osteosarcoma series, ABCB1/P‐glycoprotein (Pgp) overexpression predicts for poor outcomes. A prospective trial assess a risk‐adapted treatment strategy using mifamurtide in Pgp+ patients was performed. Methods This phase 2, multicenter, uncontrolled including 40 years old or younger with nonmetastatic extremity high‐grade stratified according Pgp expression. All received high‐dose methotrexate, doxorubicin, and cisplatin (MAP) preoperatively. In...
Angiosarcoma of bone is a rare high-grade malignant vascular tumor. The literature regarding treatment and outcome patients with this tumor limited.We performed 2 institutional retrospective study to analyze survival angiosarcoma bone.We reviewed the histologic diagnosis primary treated from 1980 2009. Demographic details, histology, treatment, were reviewed.A total 38 men 22 women (median age, 54 y) recruited. Most lesions occurred in femur pelvis. Metastatic disease at presentation was...
The spontaneous reactions of Et3SiH, Ph3GeH, Bu3SnH, and (Me3Si)3SiH with 2,2,6,6-tetramethyl-1-piperidinoxyl (TEMPO) related nitroxides have been investigated. Metal hydrides characterized by relatively weak metal−hydrogen bonds, like Ph3GeH reduce TEMPO to the corresponding hydroxylamine while no reaction is observed Et3SiH Ph3SiH. Tris(trimethylsilyl)silane, on other hand, able nitroxide amine in a ca. 1:1 ratio. By repeating above presence thermal or photochemical radical initiators,...
Background: The evidence on high-dose ifosfamide (HD-IFO) use in patients with relapsed osteosarcoma is limited. We performed a retrospective study to analyze HD-IFO activity. Methods: Patients after standard treatment [methotrexate, doxorubicin, cisplatin +/− (MAP+/−I)] measurable disease according RECIST1.1 were eligible (3 g/m2/day) continuous infusion (c.i.) days 1–5 q21d. overall response rate (ORR) (complete (CR) + partial (PR)), progression-free survival at 6-month (6m-PFS), duration...
The protective effect of Loratadine, a new generation, non-sedating antihistamine, on clinical and cellular events during the early phase reaction (EPR) late (LPR) allergen-specific conjunctival provocation test (CPT) was assessed out pollen season in 20 seasonally allergic rhino-conjunctivitis patients. After screening CPT, selected patients were randomized to Loratadine (10 mg OD) or matching placebo for 7 days. CPT repeated following treatment. Clinical responses evaluated by symptom...
Background Although elderly patients (≥70 years) represent 30% of new diagnoses soft tissue sarcoma (STS), they are underrepresented in clinical trials and often unfit to receive standard anthracycline‐based chemotherapy. Trabectedin is registered as a second‐line treatment for advanced STS characterized by favorable safety profile. Methods The aim this single‐arm, phase 2 study was investigate trabectedin (scheduled dose, 1.3‐1.5 mg/m ) first‐line with stage who inoperable coprimary...
The Italian Sarcoma Group performed this retrospective analysis of patients with advanced soft tissue sarcoma, pretreated ≥1 anthracycline-based treatment, and treated trabectedin every three weeks. Primary endpoint was to describe real-life use across Italy. Secondary endpoints included objective response rate (ORR) safety. Overall, 512 from 20 centers were evaluated. Leiomyosarcoma (37.7%)/liposarcoma (30.3%) the most prevalent histological types (abbreviated as L-sarcoma). Patients...
The protective effect of loratadine (anti-H<sub>1</sub> antagonist) on clinical and cellular processes following the early phase specific conjunctival provocation test was assessed in 20 patients affected by seasonal allergic rhinoconjunctivitis, a double-blind, randomized, placebo-controlled, parallel-group study. Patients were randomly assigned to two treatment groups, each being given single daily dose 10 mg or placebo, for 7 days, out pollen season. Pretreatment with...
In patients with relapsed osteosarcoma, the surgical excision of all metastases, defined as second complete remission (CR-2), is factor that mainly influences post-relapse survival (PRS). Currently a validated follow-up policy for osteosarcoma not available, both chest X-ray and computed tomography (CT) are suggested lung surveillance. The purpose this study to evaluate whether type imaging technique used surveillance, or CT, influenced rate CR-2 prognosis in recurrent osteosarcoma. Patients...
High-grade foci (grade 3 according to Broder's grading system) are sometimes detected in low-grade 1 and 2) central osteosarcoma. The aim of this study was retrospectively evaluate the clinical outcome patients upgraded high grade 3) after a first diagnosis osteosarcoma, following detection high-grade areas resected specimen.Of 132 with osteosarcoma at surgical biopsy our Institute, 33 were considered eligible for study.Median age 37 (range 13-58 years). Location an extremity 29 (88 %)....
Loratadine is a powerful H1 antagonist commonly employed in the treatment of allergic disorders. The present study was performed to investigate whether loratadine, addition anti-H1 activity, able modulate histamine release from human basophils. Leukocyte suspensions were prepared by dextran sedimentation peripheral venous blood drawn 10 normal subjects. Leukocytes stimulated with anti-IgE (1/5,000), N-formyl-methionyl-leucyl-phenylalanine (FMLP; μM) and Ca2+ ionophore A23187 (1 μM), cell...
The safety and efficacy of loratadine was compared with that dexchlorpheniramine in children allergic rhinitis. Twenty‐one received 0.11–0.24 mg/kg ideal body weight once daily 19 0.10–0.23 every 8 h (0.30–0.69 mg/24 h) for 14 consecutive days. Both were effective reducing nasal ocular symptoms children. Substantial improvement allergy observed at the first evaluation (day 3 treatment) maintained study duration. No significant trend abnormality laboratory parameters observed. Drowsiness...