A5060703140- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Prostate Cancer Treatment and Research
- Lipid metabolism and disorders
- Muscle metabolism and nutrition
- Advanced biosensing and bioanalysis techniques
- Nanoparticle-Based Drug Delivery
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Immune cells in cancer
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Sirtuins and Resveratrol in Medicine
- Cannabis and Cannabinoid Research
- Bone health and treatments
- Graphene and Nanomaterials Applications
- Radiopharmaceutical Chemistry and Applications
- Fungal Biology and Applications
- Chemokine receptors and signaling
- Peptidase Inhibition and Analysis
- Mesenchymal stem cell research
University of Florence
2013-2023
// Luigi Ippolito 1 , Alberto Marini 5 Lorenzo Cavallini Andrea Morandi Laura Pietrovito Gianfranco Pintus 5, 6 Elisa Giannoni Thomas Schrader 2 Martin Puhr 3 Paola Chiarugi 1, 4, * Maria Letizia Taddei 7, Department of Experimental and Clinical Biomedical Sciences, University Florence, Italy Chemistry, Duisburg-Essen, Essen, Germany Urology, Medical Innsbruck, Austria 4 Tuscany Tumor Institute “Center for Research, Transfer High Education DenoTHE”, Laboratory Cell Signaling...
There is growing evidence to suggest that bone marrow‐derived mesenchymal stem cells ( BM ‐ MSC s) are key players in tumour stroma. Here, we investigated the cross‐talk between s and osteosarcoma OS ) cells. We revealed a strong tropism of towards these identified monocyte chemoattractant protein MCP )‐1, growth‐regulated oncogene GRO )‐α transforming growth factor TGF )‐β1 as pivotal factors for chemotaxis. Once contact with cells, trans‐differentiate into cancer‐associated fibroblasts,...
Endo-, phyto- and synthetic cannabinoids have been proposed as promising anti-cancer agents able to impair cancer cells’ behavior without affecting their non-transformed counterparts. However, outcome depends not only on activity, but also the stromal cells, which coevolve with cells sustain tumor progression. Here, we show for first time that cannabinoid treatment impairs activation reactivity of cancer-associated fibroblasts (CAFs), most represented component prostate microenvironment....
Extracellular proteins are easily accessible, which presents a subproteome of molecular targets that have high diagnostic and therapeutic potential. Efforts been made to catalog the cardiac extracellular matridome analyze topology identified for design targets. Although many bioinformatics tools developed predict protein topology, has experimentally validated only very small portion membrane proteins. The aim this study was use glycoproteomics MS approach identify glycoproteins in infarcted...
Osteosarcoma (OS) is the most common primary malignancy of bone, highly aggressive and metastasizing, it mainly affects children adolescents. The current standard care for OS a combination surgery chemotherapy. However, these treatment options are not always successful, especially in cases metastatic or recurrent osteosarcomas. For this reason, research into new therapeutic strategies currently underway, immunotherapies have received considerable attention. Mifamurtide stands out among...
Previous studies by us and other groups characterized protein expression variation following long-term moderate training, whereas the effects of single bursts exercise are less known. Making use a proteomic approach, we investigated acute swimming (ASE) on carbonylation patterns in two hind limb muscles: Extensor Digitorum Longus (EDL) Soleus, mostly composed fast-twitch slow-twitch fibres, respectively. Carbonylation is one most common oxidative modifications proteins marker stress. In...
Amino polystyrene nanospheres are shown to be efficient and controllable delivery devices, capable of transporting several bioactive cargoes. Recently, the design a new device for prodrug activation, using these with palladium encapsulated onto them, has been developed successfully. To study influence cellular uptake nanodevices, we investigated response human embryonic kidney cells (HEK-293T) murine fibroblasts (L929) treated empty or palladium-conjugated amino nanospheres. identify...
The bisphosphonate Zoledronic acid (ZA) is a potent osteoclast inhibitor currently used in the clinic to reduce osteoporosis and cancer-induced osteolysis. Moreover, ZA exerts an anti-tumor effect several tumors. Despite this evidence, relevance of prostate cancer (PCa) not completely understood.To investigate administration on invasive properties PC3 cells, which are characterised by RhoA-dependent amoeboid motility.The vitro cells was evaluated cell migration 3D collagen matrices,...
Metastatic melanoma is characterized by poor prognosis and a low free-survival rate. Thanks to their high plasticity, cells are able migrate exploiting different cell motility strategies, such as the rounded/amoeboid-type elongated/mesenchymal-type motility. In particular, amoeboid strongly contributes dissemination of highly invasive no treatment targeting this process currently available for clinical application. Here, we tested Claisened Hexafluoro novel inhibitor Reported data...
Abstract Angiopoietin like (ANGPTL) proteins are secreted showing structural similarity to members of the angiopoietin family. Some ANGPTL possess pleiotropic activities, being involved in cancer lipid, glucose energy metabolisms and angiogenesis. ANGPTL7 is less characterized member family whose functional role only marginally known. In this study we provide experimental evidences that over-expressed different human cancers. To understand played by tumor biology, asked whether endogenously...