A5024239839- Inflammatory Bowel Disease
- Gut microbiota and health
- Immunotherapy and Immune Responses
- PI3K/AKT/mTOR signaling in cancer
- Mesenchymal stem cell research
- Cytokine Signaling Pathways and Interactions
- GABA and Rice Research
- Barrier Structure and Function Studies
- Peripheral Artery Disease Management
- Escherichia coli research studies
- Cancer Immunotherapy and Biomarkers
- Food composition and properties
- Inflammatory mediators and NSAID effects
- Vascular Malformations and Hemangiomas
- Vascular Tumors and Angiosarcomas
- RNA Interference and Gene Delivery
- Telomeres, Telomerase, and Senescence
- Melanoma and MAPK Pathways
- Immune Response and Inflammation
- Angiogenesis and VEGF in Cancer
- Medical and Biological Ozone Research
- Diabetic Foot Ulcer Assessment and Management
- Helicobacter pylori-related gastroenterology studies
- Cardiac tumors and thrombi
- CAR-T cell therapy research
Atlanta VA Medical Center
2016-2025
Emory University
2009-2024
Veterans Health Administration
2018-2024
Atlanta Medical Center
2017-2023
Winship Cancer Institute
2021
AID Atlanta
2021
Emory and Henry College
2021
Kyoto University
2020
Niigata University of Health and Welfare
2008-2018
Niigata University
2014-2016
Abstract Pseudomonas aeruginosa is an opportunistic pathogen that forms biofilms on tissues and other surfaces. We characterized the interaction of purified human neutrophils with P. aeruginosa, growing in biofilms, regard to morphology, oxygen consumption, phagocytosis, degranulation. Scanning electron confocal laser microscopy indicated retained a round, unpolarized, unstimulated morphology when exposed PAO1 biofilms. However, transmission demonstrated neutrophils, although rounded their...
Background Metastasis, the spread and growth of tumor cells to distant organ sites, represents most devastating attribute plays a major role in morbidity mortality cancer. Inflammation is crucial for malignant transformation survival. Thus, blocking inflammation expected serve as an effective cancer treatment. Among anti-inflammation therapies, chemokine modulation now beginning emerge from pipeline. CXC receptor-4 (CXCR4) its ligand stromal cell-derived factor-1 (CXCL12) interaction...
Factors implicated in the pathophysiology of ulcerative colitis (UC) are an abnormal immune response, defect intestinal epithelial barrier function, and gut microbiota. Currently, it is unclear whether specific bacterial strains responsible for induction inflammation, but increased tissue invasion has been described affected UC patients. Further, a quantitative qualitative microbial imbalance UC, defined as dysbiosis, characterized by increase Rhodococcus spp. , Shigella Escherichia decrease...
Global climate models predict an increase in global mean temperature and a higher frequency of intense heat spikes during this century. Cereals such as rice (Oryza sativa L.) are more susceptible to stress, mainly the gametogenesis flowering stages. During periods high temperatures, grain filling often causes serious damage quality and, therefore, yield losses. While genes encoding enzymes involved carbohydrate metabolism chalky grains have been established, significant knowledge gap exists...
Summary Superoxide dismutase ( SOD ) is widely assumed to play a role in the detoxification of reactive oxygen species caused by environmental stresses. We found characteristic expression manganese 1 MSD heat‐stress‐tolerant cultivar rice Oryza sativa ). The deduced amino acid sequence contains signal and an N ‐glycosylation site. Confocal imaging analysis onion cells transiently expressing 1‐ YFP showed Golgi apparatus plastids, indicating that unique Golgi/plastid‐type . To evaluate...
Abstract Molecular events activating the PI3K pathway are frequently detected in human tumors and activation of signaling alters numerous cellular processes including tumor cell proliferation, survival, motility. More recent studies have highlighted impact on response to interferons other immunologic relevant antitumor immunity. Given ability IFNγ regulate antigen processing presentation pivotal role MHC class I (MHCI) II (MHCII) expression T-cell–mediated immunity, we sought determine MHCI...
Objective: The mechanisms of structured exercise therapy (SET) in peripheral artery disease (PAD) are not clear. We have developed an SET module for our large animal model ischemic myopathy. hypothesized that would increase muscle strength and walking distance this model. objective was to discover the SET-dependent involved process. Approach: After induction unilateral hind limb ischemia, three animals were exposed standard environmental enrichment (sedentary or SED) four underwent thrice...
Propranolol is a widely used beta blocker that consists of racemic mixture R and S stereoisomers. Only the stereoisomer has significant activity against beta-adrenergic receptor. A fortuitous clinical observation was made in an infant who received propranolol for cardiac disease, regression hemangioma infancy noted. This led to widespread use treatment large life-threatening hemangiomas infancy. Infants receiving require monitoring ensure they do not suffer from side effects related...
ABSTRACT Previously, we have identified a large gene ( lifA , for lymphocyte inhibitory factor A) in enteropathogenic Escherichia coli (EPEC) encoding protein termed lymphostatin that suppresses cytokine expression vitro. This also functions as an adhesion enterohemorrhagic E. (EHEC) and Shiga toxin-producing is alternatively known efa1 (EHEC adherence 1). The / present Citrobacter rodentium enteric pathogen causes disease transmissible murine colonic hyperplasia (TMCH), which induces...
Exercise upregulates the expression of NR4A receptors, which are involved in regulation glucose and fatty acid utilization genes skeletal muscle. The aims our study were 1) to determine role local contractile activity on mRNA muscle during exercise; 2) elucidate mechanisms underlying induction response activity. Rats subjected an acute 3-h low-intensity swimming or a treadmill running as model endurance exercise. Low-intensity increased NR4A1 NR4A3 triceps but not soleus Conversely,...
Abstract IGF1R and CD44 are overexpressed in most advanced melanomas so we designed chemotherapeutic nanoparticles to target those receptors. Tris(dibenzylideneacetone)dipalladium (Tris DBA-Pd) is a novel inhibitor of N -myristoyltransferase 1 (NMT-1) has proven vivo activity against melanoma. However, poor solubility impairs its effectiveness. To improve therapeutic efficacy overcome drug resistance melanomas, synthesized Tris DBA-Pd hyaluronic acid HANP) evaluated them xenografts LM36R, an...
GNAQ is mutated in vascular and melanocytic lesions, including malformations nevi. No vivo model of activation endothelial cells has previously been described. We introduce mutant into a murine cell line, MS1. The resultant transduced exhibit novel phenotype vivo, with extensive vasoformative forming aberrant lumens similar to those seen malformations. ATAC-seq analysis reveals c-Kit the demonstrate that expressed authentic human Sturge–Weber malformations, indicating druggable target for...
Depudecin, a microbial metabolite containing two epoxide groups, was tested for its anti-angiogenic activity in an vivo assay system involving the chorioallantoic membrane of growing chick embryo. The inhibited embryonic angiogenesis dose-dependent manner with ID50 320ng (1.5 nmol) per egg. It also affected growth vascular endothelial cells, key event process vivo. These results suggest that depudecin could be promising as agent and action involves inhibitory effect on cell growth.
β-Adrenergic stimulation and exercise up-regulate the mRNA expression of nuclear receptor NR4A3, which is involved in regulation glucose fatty acid utilization genes skeletal muscle. The objective our study was to examine effects β-adrenergic on NR4A3 protein rat A single subcutaneous injection clenbuterol, a β2-adrenergic (β2-AR) agonist, increased fast-twitch glycolytic triceps On other hand, an acute 3-h session either treadmill running or swimming did not increase level exercised muscle,...
Epidemiological and genetic studies suggest a role for enteric flora in the pathogenesis of Crohn's disease (CD). disease-associated Escherichia coli (CDEC) is characterized by their ability to invade epithelial cells survive induce high concentration TNF-α from infected macrophages. However, molecular mechanisms CDEC survival macrophages are not completely understood.Intracellular strain LF82 isolated inflamed ileum tissue, 13I colonic control E. strains were tested murine macrophage cell...