A5002166829- Acupuncture Treatment Research Studies
- Traditional Chinese Medicine Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Salmonella and Campylobacter epidemiology
- Pancreatic function and diabetes
- Diet and metabolism studies
- Sirtuins and Resveratrol in Medicine
- Sphingolipid Metabolism and Signaling
- Neurological Disease Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Dietary Effects on Health
- Liver Disease Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Listeria monocytogenes in Food Safety
- Barrier Structure and Function Studies
- Microbial Metabolism and Applications
- Diet, Metabolism, and Disease
- Alcohol Consumption and Health Effects
- Ion Transport and Channel Regulation
- Fungal Biology and Applications
- Antibiotic Resistance in Bacteria
- Autophagy in Disease and Therapy
- Natural Compounds in Disease Treatment
Anhui Medical University
2024-2025
Emory University
2016-2024
University at Albany, State University of New York
2024
Microbiology Institute of Shaanxi
2024
Institute of Microbiology
2024
Chinese Academy of Sciences
2024
Beihang University
2024
Zhengzhou University
2021-2023
Xuzhou Medical College
2022-2023
United States Department of Veterans Affairs
2022-2023
Abstract Salmonella enterica serovar Typhimurium ( S . Typhimurium) is a major cause of salmonellosis, and the emergence multidrug-resistant pathovariants has become growing concern. Here, we investigate distinct rough colony variant exhibiting strong biofilm-forming ability isolated in China. Whole-genome sequencing on 2,212 Chinese isolates 1,739 publicly available genomes reveals population structure evolutionary history variants. Characterized by macro, red, dry, (mrdar) colonies, these...
Pathological calcification represents an event that consequently leads to a distinct elevation in the morbidity and mortality of patients with chronic kidney disease (CKD) addition strengthening its correlation hyperphosphatemia. Epigenomic regulation by specific microRNAs (miRNAs) is reported be involved ectopic calcification. However, finer molecular mechanisms governing this remain unclear. Hence, study aimed identify potential miRNAs vascular (VC) development progression. Initially,...
To investigate the resistance mechanism of a Salmonella Typhimurium (S. Typhimurium) isolated from faecal sample an infant, which exhibited concurrent to ceftriaxone, ciprofloxacin and azithromycin. Antimicrobial susceptibility testing was performed by broth microdilution in two kinds drug-sensitive plates. (AMR) genes were identified whole genome sequencing bioinformatics analysis. Genotyping strain multilocus sequence typing (MLST). Plasmid DNA sequenced analysed using plasmid tools. The...
Salmonella contamination of eggs and egg shells has been identified as a public health problem worldwide. Here, we reported an outbreak severe gastrointestinal symptoms caused by enterica serovar Enteritidis ( S . enteritidis) in China. We evaluated the using epidemiological surveys, routine laboratory testing methods, whole genome sequencing (WGS). This occurred canteen Beijing, during March 9–11, 2021, 225 324 diners who have eaten at showed symptoms. The had characteristical clinical...
Background & AimsRegeneration of the epithelium by stem cells in intestine is supported intrinsic and extrinsic factors. Lysophosphatidic acid (LPA), a bioactive lipid mediator, regulates many cellular functions, including cell proliferation, survival, cytokine secretion. Here, we identify LPA5 receptor as potent regulator survival transit-amplifying intestine.MethodsWe have used genetic mouse models conditional deletion Lpar5, Lpar5f/f;Rosa-CreERT (Lpar5KO), intestinal epithelial...
We used mice lacking expression of the lysophosphatidic acid receptor 5 (LPA ) in intestinal epithelial cells and organoids to show that LPA protects stem progenitors from radiation-induced injury. induces YAP signaling regulates Paneth cells.
The aim of the present study was to investigate effect metformin on β‑glycerophosphate‑induced calcification vascular smooth muscle cells (VSMCs) and possible mechanisms underlying this. Using an established VSMC model, VSMCs were first treated with β‑glycerophosphate, before metformin, 3‑methyladenine compound C added cell cultures in different combinations. Calcium deposition examined by Alizarin Red S staining using O‑cresolphthalein complexone method. To assess occurrence autophagy,...
Background & AimsDiarrhea is one of the most common illnesses and often caused by bacterial infection. Recently, we have shown that human Na+/H+ exchanger NHE3 (hNHE3), but not non-human NHE3s, interacts with E3 ubiquitin ligase Nedd4-2. We hypothesize this property hNHE3 contributes to increased severity diarrhea in humans.MethodsWe used humanized mice expressing intestine (hNHE3int) compare contribution mouse induced cholera toxin (CTX) enteropathogenic Escherichia coli (EPEC). measured...
Na+ /H+ exchanger NHE3 of human or primates differs from other animals by having a PY motif, which mediates interaction with the E3 ubiquitin (Ub) ligase Nedd4-2. Ub-conjugation Nedd4-2 regulates endocytosis but does not affect its cellular expression. Because is reversible process, aim this study to identify deubiquitinating enzyme (DUB) regulating post-endosomal fate NHE3. Using an activity-based chemical screening, we identified specific protease-7 (USP7) and USP10 that bind The roles...
Glycemic control is the key to management of type 2 diabetes. Metformin an effective, widely used drug for controlling plasma glucose levels in diabetes, but it often culprit gastrointestinal adverse effects such as abdominal pain, nausea, indigestion, vomiting, and diarrhea. Diarrhea a complex disease altered intestinal transport electrolytes fluid common cause Na + /H exchanger 3 (NHE3, SLC9A3 ) major absorptive mechanism intestine our previous study has demonstrated that decreased NHE3...
It was the aim of this study to determine whether abdominal massage reverses high-fat diet-induced insulin resistance compared with RSV treatment. A total sixty male Sprague-Dawley rats were randomly placed in one four groups:the non-fat diet (NFD), (HFD), HFD (HFD+ AM), and plus resveratrol RSV). For eight weeks, fed diets create resistance, followed by six weeks either AM or RSV. Molecular mechanisms adipogenesis cytokine production investigated. The model rat adipose tissue showed...
Abstract Abdominal massage (AM), a traditional Chinese medicine-based treatment method, has received considerable attention in the recent years. The aim of present study was to investigate effect AM on high-fat diet (HFD)-induced insulin resistance (IR) comparison with resveratrol (RSV) treatment. Forty-eight male Sprague-Dawley rats were randomly divided into following four groups: standard chow (control group), (model HFD + abdominal (AM and (RSV group). A rat model IR established by...
Electroneutral NaCl transport by Na
Gastrointestinal (GI) complications, including diarrhea, constipation, and gastroparesis, are common in patients with diabetes. Dysregulation of the Na