A5034030763- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Mesenchymal stem cell research
- Connective Tissue Growth Factor Research
- Gastrointestinal disorders and treatments
- Diabetic Foot Ulcer Assessment and Management
- Renal and Vascular Pathologies
- Bariatric Surgery and Outcomes
- Biomarkers in Disease Mechanisms
- Muscle Physiology and Disorders
- Cardiovascular Health and Disease Prevention
- Gastrointestinal Tumor Research and Treatment
- Biomedical Ethics and Regulation
- Biliary and Gastrointestinal Fistulas
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Disease and Adiposity
- Muscle metabolism and nutrition
- Medical and Biological Ozone Research
- Cardiovascular and exercise physiology
- Obesity and Health Practices
Atlanta VA Medical Center
2023-2025
Emory University
2022-2025
Emory University Hospital
2023
Atlanta Medical Center
2023
Objective: The mechanisms of structured exercise therapy (SET) in peripheral artery disease (PAD) are not clear. We have developed an SET module for our large animal model ischemic myopathy. hypothesized that would increase muscle strength and walking distance this model. objective was to discover the SET-dependent involved process. Approach: After induction unilateral hind limb ischemia, three animals were exposed standard environmental enrichment (sedentary or SED) four underwent thrice...
Arterial ring testing is the gold standard for measuring arterial function. Increased tone through contraction and impaired endothelial relaxation (endothelial dysfunction) are key metrics of health in peripheral disease (PAD). To allow comparative arteries during laboratory hours, storage buffers conditions have been used to extend functional life arteries. Various compared, but there has not a robust comparison or validation human The objective this work optimize segments cell (EC) murine...
Abstract Background Peripheral arterial disease (PAD) is the 3 rd leading type of atherosclerotic (ASD) morbidity. Arterial stiffness intimately connected to onset and progression peripheral artery (PAD). The role stiffening on flow-mediated plaque formation not well understood. objective this study discover endothelial cell (EC) pathways under PAD conditions test modifiability these ASD. Methods in mice were conferred by partial carotid ligation induce disturbed Flow (D-flow) pre-stiffened...
Diabetes Mellitus (DM) affects 34.2 million Americans. DM impairs the body’s reparative machinery leading to early onset chronic illness (peripheral arterial disease (PAD), neuropathy, nephropathy, and retinopathy, latter being hallmarks of microvascular disease). Patients with DM+PAD have increased risk major amputation. Mesenchymal stem cells (MSCs) are found in all tissues providing paracrine trophic support for new tissue. This study’s objective was identify intracellular epigenetic...
Peripheral artery disease (PAD) causes an ischemic myopathy in the lower extremity muscles, which contributes to patient functional disability. Although structured exercise therapy is a leading therapeutic improve ambulatory function, impact of on PAD unclear. Using our porcine model PAD, we sought elucidate effect hindlimb ischemia markers 1) muscle damage (caspase 3, myogenic differentiation 1 (MyoD), and Forkhead box protein O1 (FOXO1)), 2) turnover (autophagic flux proteolytic activity),...