A5085858872- Peripheral Artery Disease Management
- Cardiovascular and exercise physiology
- Diabetic Foot Ulcer Assessment and Management
- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Muscle and Compartmental Disorders
- Mitochondrial Function and Pathology
- Cerebrovascular and Carotid Artery Diseases
- Adipose Tissue and Metabolism
- Balance, Gait, and Falls Prevention
- Dialysis and Renal Disease Management
- Heart Rate Variability and Autonomic Control
- Medical and Biological Ozone Research
- Exercise and Physiological Responses
- Cardiovascular Effects of Exercise
- Lipoproteins and Cardiovascular Health
- Stroke Rehabilitation and Recovery
- Sport Psychology and Performance
- Sports Performance and Training
- Chronic Kidney Disease and Diabetes
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Health and Disease Prevention
- Connective tissue disorders research
- Musculoskeletal pain and rehabilitation
- Non-Invasive Vital Sign Monitoring
University of West Florida
2024-2025
Baylor University
2018-2024
University of Nebraska Medical Center
2012-2024
Marcus (United States)
2024
RELX Group (Netherlands)
2022
Michigan United
2022
Temple College
2022
Florida State University
2018-2020
Dermatology Associates of Tallahassee
2019
Longwood University
2015
Peripheral arterial disease (PAD), a manifestation of systemic atherosclerosis that produces blockages in arteries supplying the legs, affects an estimated 27 million people Europe and North America. Increased production reactive oxygen species by dysfunctional mitochondria leg muscles PAD patients is viewed as key mechanism initiation progression disease. Previous studies demonstrated increased oxidative damage homogenates biopsy specimens from gastrocnemius compared to controls, but did...
Peripheral artery disease (PAD), a manifestation of systemic atherosclerosis that produces blockages in the arteries supplying legs, affects approximately 5% Americans. We have previously, demonstrated myopathy characterized by myofiber oxidative damage and degeneration is central to PAD pathophysiology.In this study, we hypothesized increased myofibers gastrocnemius patients myofiber-type selective correlates with reduced size.Needle biopsies were taken from 53 (28 early 25 advanced PAD)...
Patients with peripheral artery disease (PAD) develop a myopathy in their ischemic lower extremities, which is characterized by myofiber degeneration, mitochondrial dysfunction and impaired limb function. Desmin, protein of the cytoskeleton, central to maintenance structure, shape function its organelles, especially mitochondria, translation sarcomere contraction into muscle contraction. In this study, we investigated hypothesis that disruption desmin network occurs gastrocnemius myofibers...
Lower leg ischemia, myopathy, and limb dysfunction are distinguishing features of peripheral artery disease (PAD). The myopathy PAD is characterized by myofiber degeneration in association with extracellular matrix expansion, increased expression transforming growth factor-beta 1 (TGF-β1; a pro-fibrotic cytokine). In this study, we evaluated cellular TGF-β1 gastrocnemius control (CTRL) patients its relationship to deposited collagen, fibroblast accumulation hemodynamics.Gastrocnemius...
Objective: The mechanisms of structured exercise therapy (SET) in peripheral artery disease (PAD) are not clear. We have developed an SET module for our large animal model ischemic myopathy. hypothesized that would increase muscle strength and walking distance this model. objective was to discover the SET-dependent involved process. Approach: After induction unilateral hind limb ischemia, three animals were exposed standard environmental enrichment (sedentary or SED) four underwent thrice...
Peripheral arterial disease (PAD), which affects ∼10 million Americans, is characterized by atherosclerosis of the noncoronary arteries. PAD produces a progressive accumulation ischemic injury to legs, manifested as gradual degradation gastrocnemius histology. In this study, we evaluated hypothesis that quantitative morphological parameters myofibers change in consistent manner during progression PAD, provide an objective grading muscle degeneration limb, and correlate clinical stage PAD....
This study evaluated the hypothesis that protein concentration and mitochondrial content in gastrocnemius biopsies from patients with peripheral arterial disease (PAD) predict mortality rates.PAD experience advancing myopathy characterized by dysfunction, myofiber degradation, fibrosis their ischemic legs, along increased rates.Samples of PAD were used for all analyses. Protein was normalized to muscle wet weight, citrate synthase activity (standard measure cells) weight concentration. data...
Peripheral artery disease (PAD) pathophysiology extends beyond hemodynamics to include other operating mechanisms, including endothelial dysfunction. Oxidative stress may be linked dysfunction by reducing nitric oxide (NO) bioavailability. We aimed investigate whether the NO system and its regulators are altered in setting of PAD assess relationship between bioavailability oxidative stress. Sera from 35 patients with intermittent claudication (IC), 26 critical limb ischemia (CLI), non-PAD...
Thoracic aortic aneurysm and dissection are life-threatening complications of Marfan syndrome (MFS). Studies human mouse samples from late stage MFS demonstrate increased TGF-β activation/signaling diffuse matrix changes. However, the role smooth muscle cell (SMC) phenotype in early formation has yet to be fully elucidated. As our objective, we investigated whether an altered SMC plays a MFS. We describe previously unrecognized concordant findings aortas murine model MFS, mgR, during...
Work from our laboratory documents pathological events, including myofiber oxidative damage and degeneration, myofibrosis, micro-vessel (diameter = 50–150 μm) remodeling, collagenous investment of terminal micro-vessels ≤ 15 µm) in the calf muscle patients with Peripheral Artery Disease (PAD). In this study, we evaluate hypothesis that vascular pathology associated legs PAD encompasses pathologic changes to smallest muscle. Biopsies were collected control subjects Fontaine Stage II IV PAD....
Previous studies have shown that chronic heavy alcohol consumption and of a high-fat (HF) diet can independently contribute to skeletal muscle oxidative stress mitochondrial dysfunction, yet the concurrent effect these risk factors remains unclear. We aimed assess different dietary compositions on activity markers. Male female mice were randomized an (EtOH)-free HF diet, + EtOH or low-Fat (LF) for 6 weeks. At end study, electron transport chain complex expression as well antioxidant...
Clinicians are in need of valid and objective measures postural sway. Accelerometers have been shown to be suitable alternatives expensive stationary force plates. We evaluated the test-retest reliability balance task discrimination capability a new wireless triaxial accelerometer (YEI 3-Space Sensor). Four testing conditions (eyes open or closed, while on firm compliant surface) were used progressively challenge static 20 healthy male (n = 8) female 12) older adults (mean age 81 ± 4.3 y)....