A5005585008- Aortic aneurysm repair treatments
- Connective tissue disorders research
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Infectious Aortic and Vascular Conditions
- Protease and Inhibitor Mechanisms
- Macrophage Migration Inhibitory Factor
- Coronary Interventions and Diagnostics
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Peripheral Nerve Disorders
- Intracranial Aneurysms: Treatment and Complications
- Immune cells in cancer
- Cerebrovascular and Carotid Artery Diseases
- Aortic Thrombus and Embolism
- Reconstructive Surgery and Microvascular Techniques
- Cardiac tumors and thrombi
- Galectins and Cancer Biology
- Lymphatic System and Diseases
- Cardiac and Coronary Surgery Techniques
- Spinal Cord Injury Research
- Xenotransplantation and immune response
University of Nebraska Medical Center
2008-2024
Baxter (United States)
2013-2018
MedStar Georgetown University Hospital
2018
MedStar Washington Hospital Center
2018
Georgetown University
2018
University of Nebraska at Omaha
1998-2018
VA Nebraska Western Iowa Health Care System
2013
Houston Methodist
2005
Methodist Hospital
2005
University of Kansas Medical Center
1998
Abstract —Degradation of the elastic media is a hallmark abdominal aortic aneurysms (AAAs). We examined expression 2 elastolytic matrix metalloproteinases (MMPs), MMP-2 and MMP-9, in AAA tissues compared with those from atherosclerotic occlusive disease (AOD) nondiseased control tissues. Quantitative competitive reverse transcription–polymerase chain reaction gelatin zymography showed increased MMP-9 mRNA protein both AOD tissue, but there was no significant difference between AOD. In...
Abdominal aortic aneurysms are inflammatory in nature and associated with some risk factors that also lead to atherosclerotic occlusive disease, most notably smoking. The purpose of our study was identify differential cytokine expression patients abdominal aneurysm those disease. Based on this analysis, we further explored compared the mechanism action IL (interleukin)-1β versus TNF-α (tumor necrosis factor-α) formation.IL-1β differentially expressed human plasma lower levels detected...
Macrophages play critical roles in events ranging from host defense to obesity and cancer, where they infiltrate affected tissues orchestrate immune responses tandem with the remodeling of extracellular matrix (ECM). Despite dual played by macrophages inflammation, functions macrophage-derived proteinases are typically relegated tissue-invasive or -degradative events. Here we report that membrane-tethered metalloenzyme MT1-MMP not only serves as an ECM-directed proteinase, but unexpectedly...
Thoracic aortic aneurysm and dissection are life-threatening complications of Marfan syndrome (MFS). Studies human mouse samples from late stage MFS demonstrate increased TGF-β activation/signaling diffuse matrix changes. However, the role smooth muscle cell (SMC) phenotype in early formation has yet to be fully elucidated. As our objective, we investigated whether an altered SMC plays a MFS. We describe previously unrecognized concordant findings aortas murine model MFS, mgR, during...
• A prospective comparison of the findings on standard completion arteriography with those seen using videoangioscopy was done following 49 cases "femorodistal" bypass grafting in 47 patients. The two techniques were compared respect to detection technical defects, modification surgical procedures, early graft patency (72 hours), and complications. Completion specific (95%) but only moderately sensitive (67%) angioscopy for problems. Following angioscopy, significant alterations procedure...
The leading cause of mortality in patients with Marfan syndrome (MFS) is thoracic aortic aneurysm and dissection. Notch signaling essential for vessel morphogenesis function. However, the role pathology smooth muscle cell (SMC) differentiation not completely understood. RNA-sequencing on ascending tissue from a mouse model MFS, Fbn1mgR/mgR , wild-type controls was performed. 3 expression activation were confirmed real-time RT-PCR, immunohistochemistry, Western blot. mice treated γ-secretase...
This paper presents micro-particle tracking velocimetry measurements over cultured bovine aortic endothelial cell monolayers in microchannels. The objective was to quantify fluid forces and morphology at the sub-cellular scale for subjected steady shear rates of 5, 10, 20 dyn/cm2. ultimate goal this study develop an experimental methodology vitro detailed physiologically realistic healthy diseased conditions. Cell topography, stress, pressure distributions were calculated from sets velocity...
The cellular infiltrate in xenografts suggests that macrophages may be involved xenograft rejection. However, the precise role of rejection has not yet been fully addressed.Xenogeneic rat skin grafts were transplanted to macrophage colony stimulating factor (M-CSF)/macrophage-deficient osteopetrotic ([OP]-/-) and wild-type control mice. Skin graft survival antidonor humoral responses quantified.Xenogeneic survived 13 days mice, was significantly prolonged 24 [OP]-/- mice (P<0.01). Similar...
Abdominal aortic aneurysm (AAA) is a common, progressive and potentially fatal dilation of the most distal segment. Multiple studies with longitudinal follow-up AAA have identified markedly slower progression among patients affected diabetes. Understanding molecular pathway responsible for growth inhibition could implications therapy in nondiabetic patients. Toward this end, we investigated effects hyperglycemia murine model carefully monitored cohort from Noninvasive Treatment AAA-Clinical...