A5073023506- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Sinusitis and nasal conditions
- Oral and Maxillofacial Pathology
- Cancer and Skin Lesions
- Viral-associated cancers and disorders
- Sarcoma Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Cancer-related molecular mechanisms research
- Cervical Cancer and HPV Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphoma Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Tumors and Oncological Cases
- Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Bone Tumor Diagnosis and Treatments
- Cancer-related Molecular Pathways
- Breast Implant and Reconstruction
- Meningioma and schwannoma management
- Breast Lesions and Carcinomas
Fondazione IRCCS Istituto Nazionale dei Tumori
2014-2023
University of Milan
2019
ChromoLogic (United States)
2011
IFOM
2006
Tumori Foundation
1998
Istituto Nazionale di Documentazione Innovazione e Ricerca Educativa
1998
Human papillomavirus (HPV) DNA tumors actively integrating the E6 and E7 oncogenes have a distinct biologic behavior resulting in more favorable prognosis. To which extent viral integration by itself, and/or associated wild-type (wt) TP53 status, functional p16 contribute to prognosis is unclear.To clarify how presence of high-risk (HR) -HPV, TP53, p16INK4a status interact with clinical outcome, we considered retrospective series 90 consecutive oropharyngeal cancer patients treated primarily...
Purpose: Prognosis of patients with advanced oral cavity cancer is worth improving. Chemotherapy has been reported to be especially active in tumors. Here we repeat the results a randomized, multicenter trial enrolling resectable, stage T2–T4 (> 3 cm), N0–N2, M0 untreated, squamous cell carcinoma cavity. Patients and Methods: were randomly assigned three cycles cisplatin fluorouracil followed by surgery (chemotherapy arm) or alone (control arm). In both arms, postoperative radiotherapy...
Androgen deprivation therapy has some clinical activity in selected salivary gland cancer histotypes, with androgen receptor expression.We retrospectively analyzed patients receptor-expressing recurrent/metastatic cancer, treated therapy. Protein expression of and ErbB family members was investigated. Progression-free survival (PFS) overall (OS) were the main endpoints.Seventeen identified. No significant toxicities reported. Overall response rate 64.7%; 3-year PFS 5-year OS 11.8% 19.3%,...
PURPOSE To find out if TP53 functional status predicts response to neoadjuvant chemotherapy and thus may be helpful during treatment decision making of oral cavity squamous cell carcinoma (SCC) patients. PATIENTS AND METHODS We analyzed the predictive value mutations their on basis transactivation activity p53 mutant proteins in 53 pretreatment biopsies SCC patients receiving primary cisplatin fluorouracil followed by surgery. Results The surgical specimens showed that 15 (28%) achieved a...
Background The treatment of patients with recurrent and/or metastatic (R/M) salivary gland adenoid cystic carcinoma (ACC) remains an unmet need. Methods Patients R/M disease a history clinical or symptomatic progression within 6 months and maximum 1 previous line chemotherapy multiple kinase inhibitor received oral lenvatinib at dose 24 mg/day. primary endpoint was the objective response rate; secondary endpoints included quality life (QOL) (according to European Organization for Research...
Purpose To assess the role of TP53 status in predicting pathologic complete remission after primary chemotherapy patients with ethmoidal intestinal-type adenocarcinoma (ITAC). Patients and Methods Thirty ITAC enrolled onto a phase II study received cisplatin, fluorouracil, leucovorin (PFL) followed by surgery radiation. On surgical specimens, absence viable tumor cells was defined as (pCR). status/p53 function, analyzed on pretreatment biopsies, were retrospectively correlated results...
The purpose of our study was to identify the role work exposure organic dusts in patients with malignant paranasal sinus tumors.We analyzed all surgically treated for a tumor at institution between 1987 and 2006. All were specifically asked about their occupational history. site classified as maxillary or ethmoid sinus. Adenocarcinomas divided into intestinal type (ITAC) non-ITAC.The sample included 345 301 Regarding sinus, we found an 148 153 ITAC, 3 16 non-ITAC adenocarcinoma, 10 176 other...
Abstract Intestinal‐type adenocarcinoma (ITAC) of the nasal cavity and paranasal sinuses is an uncommon tumor associated with occupational exposure to dusts different origin. Few investigations addressed molecular alterations in ITAC mainly focused on TP53 , K‐ ras H‐ gene mutations. The occurrence p14 ARF p16 INK4a deregulation mutations was investigated 21 consecutive untreated ITACs cases, 17 known professional exposure. No were found. In patients exposure, cumulative evidence or...
Anatomists and surgeons have underestimated the importance of understanding anatomic connective frame inframammary region. The submammary fold does not originate as a self-governing unit but depends on breast mould fine superficial fascial system suspension. authors investigated anatomy subcutaneous territory in cadaver live dissection with histologic analyses, without sharing theories about fascia splitting ligament existence. understood that reliable correction contour reconstruction may...
BackgroundTo investigate the activity and safety of afatinib in preoperative treatment squamous cell carcinoma head neck (SCCHN).Patients methodsThis study was an open-label, randomized, multicenter, phase II window opportunity trial. Treatment-naïve SCCHN patients selected for primary curative surgery were randomized (5 : 1 ratio) to receive during 14 days (day –15 until day –1) before 0) or no treatment. Tumor biopsies, 2-[fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography...
Abstract Background Patients with prognosis recurrent/metastatic (R/M) salivary gland carcinomas (SGCs) are poor. Activity of axitinib was demonstrated in adenoid cystic carcinoma (ACC). We tested a larger cohort R/M SGCs including non‐ACC. Methods Axitinib administered at 10 mg daily (dose escalation allowed) until progression or unacceptable toxicity. Null hypothesis would be rejected if more than 3 26 responses were observed. Results Twenty‐six patients (50% male; 6 ACC, 20 non‐ACC)...
Objective Outcomes of locally advanced epithelial sinonasal cancers remain unsatisfactory; moreover, only limited and heterogeneous data exist on prognostic factors. Methods We reviewed all consecutive patients with American Joint Committee Cancer stage III to IV treated platinum‐based induction chemotherapy (IC) followed by locoregional treatment between 1996 2015. Results identified 69 a multimodal approach (IC, surgery, radiotherapy). Overall, 44 recurred (64%). Of those, 19 received...
The purpose of this study was to evaluate the results a mono-institutional series patients treated with anterior craniofacial resection for malignant paranasal sinus tumors.We analyzed all tumors at our institution between 1987 and 2007. All were classified according both American Joint Committee on Cancer (AJCC)-2002 Istituto Nazionale Tumori (INT) classifications.The sample included 366 patients. There intraorbital spread in 108 cases. skull base eroded 127 patients, dura or brain...
// Salvatore Alfieri 1 , Nicola Alessandro Iacovelli 2 Sara Marceglia 3 Irene Lasorsa Carlo Resteghini Francesca Taverna 4 Arabella Mazzocchi Ester Orlandi Marco Guzzo 5 Roberto Bianchi Diana Fanti 6 Laura Pala 7 Racca 8 Roee Dvir Pasquale Quattrone 9 Annunziata Gloghini Chiara Costanza Volpi Roberta Granata Cristiana Bergamini Locati Lisa Licitra 1, 10 and Paolo Bossi Department of Medical Oncology 3, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Radiation Oncology,...
The activity of androgen-deprivation therapy (ADT) in androgen receptor-positive (AR+) salivary gland carcinomas (SGCs) has been established the past few years. Second-line treatment castration-resistant patients is still unknown. We investigated abiraterone acetate as second-line ADT-resistant, AR+ with SGC.This was a single-institution phase II trial. A two-stage Simon's design applied. primary end point confirmed objective response rate. Secondary points were disease control rate, safety,...