A5086976541- Mesenchymal stem cell research
- Cardiac Ischemia and Reperfusion
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Mechanical Circulatory Support Devices
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced MRI Techniques and Applications
- Galectins and Cancer Biology
- Aortic aneurysm repair treatments
- Cardiac tumors and thrombi
- Salivary Gland Tumors Diagnosis and Treatment
- Cardiac electrophysiology and arrhythmias
- Ear and Head Tumors
- Cardiac Arrhythmias and Treatments
- Peptidase Inhibition and Analysis
- Heart Failure Treatment and Management
- GDF15 and Related Biomarkers
- Congenital Heart Disease Studies
- Acute Myocardial Infarction Research
- Health and Conflict Studies
- Cardiovascular Function and Risk Factors
Albert Schweitzer Ziekenhuis
2011-2022
University Medical Center
2005-2019
Radboud University Nijmegen
2017-2019
Radboud University Medical Center
2017-2019
Albert Schweitzer Hospital
2011-2015
Erasmus MC
2005-2012
Erasmus University Rotterdam
1978-2012
Duke University Hospital
2003-2005
Duke Medical Center
2003-2005
Rotterdam University of Applied Sciences
2003-2005
Mouse myocardial infarction (MI) models are frequently used research tools. The most commonly applied model is coronary artery ligation. However, ligation often gives rise to apical aneurysmatic infarcts of variable size. Other infarct include cryoinfarction, which produces reproducible the anterior wall. Thus far, this has not been extensively described in mice. Therefore, we developed a murine cryoinfarction and compared it with Studies were performed under isoflurane anesthesia follow-up...
In patients with atrial fibrillation, minor troponin I elevation is regularly detected; however, the prognostic significance of this finding unknown. We therefore sought to examine value elevated in fibrillation.A prospective study was conducted analysing all consecutive admitted fibrillation a 2-year period. Patients an ST-elevation myocardial infarction (MI) were excluded. Minor defined as level between 0.15 and 0.65 ng/mL, which still below 99th percentile upper reference limit. A...
Background— Multiple cell types are being proposed for cardiac repair, but side-by-side comparisons lacking. We tested the hypothesis that intracardiac transplantation of autologous bone marrow- or skeletal muscle-derived progenitor cells improve regional heart function to a similar degree. Methods and Results— Thirty-nine New Zealand White rabbits underwent cryoinjury left ventricle simultaneous hind limb marrow aspiration soleus muscle biopsy. Both were expanded in vitro. After 2 weeks, 10...
Labeling stem cells with FDA-approved superparamagnetic iron oxide particles makes it possible to track in vivo magnetic resonance imaging (MRI), but high intracellular levels of can cause free radical formation and cytotoxicity. We hypothesized that the use cationic liposomes would increase labeling efficiency without toxic effects. Rabbit skeletal myoblasts were labeled by: 1) uptake incorporated into transfection (group I) or 2) customary endocytosis II). In both groups, cell...
Postconditioning (POC) is known as the phenomenon whereby brief intermittent ischemia applied at onset of reperfusion following index limits myocardial infarct size. Whereas there evidence that algorithm POC stimulus an important determinant protective efficacy, importance duration on outcome effects has received little attention. Pentobarbital sodium-anesthetized Wistar rats were therefore subjected to produced by coronary artery occlusions (CAO) varying (15-120 min) followed reperfusion,...
Studies on serially measured GDF-15 (growth differentiation factor 15) in acute heart failure (HF) are limited. Moreover, several pathophysiological pathways contribute to HF. Therefore, we aimed explore the (additional) prognostic value of using a multi-marker approach more accurately predict HF risk.TRIUMPH (Translational Initiative Unique and Novel Strategies for Management Patients With Heart Failure) is prospective cohort 496 patients with who were enrolled 14 hospitals Netherlands...
Aims Magnetic resonance imaging (MRI) has been proposed as a tool to track iron oxide-labelled cells within myocardial infarction (MI). However, infarct reperfusion aggravates microvascular obstruction (MO) and causes haemorrhage. We hypothesized that haemorrhagic MI magnetic susceptibility-induced signal voids may interfere with cell detection. Methods results Pigs (n = 23) underwent 2 h occlusion of the left circumflex artery. Cine, T2*-weighted, perfusion, delayed enhancement MRI scans...
Stem cell therapy after myocardial infarction (MI) has been studied in models of permanent coronary occlusion. We the effect intracoronary administration unselected bone marrow (BM) and mononuclear cells (MNC) a porcine model reperfused MI.In 34 swine, left circumflex artery was balloon-occluded for 2 h followed by reperfusion. Ten swine without MI served as controls. All underwent magnetic resonance imaging (MRI) 1 week post-MI. The next day, 10 30 surviving received BM, other MNC,...
Several clinical studies have evaluated the association between galectin-3 levels and outcome in patients with heart failure (HF). However, little is known about predictive value of repeated measurements. This study evaluates prognostic time-dependent measurements acute HF patients.In TRIUMPH (Translational Initiative on Unique Novel Strategies for Management Patients Heart Failure) cohort study, 496 were enrolled 14 hospitals The Netherlands, 2009 2014. Repeated blood samples (7) drawn...
From 1987 to 1992, 22 children (age 0 days-14 years) were operated for congenital bronchopulmonary disease. One patient had a hamartoma. Four bronchogenic cyst, in 1 combined with an esophageal duplication. Intrapulmonary sequestration was diagnosed 3 children; one of whom duplication as well. localized emphysema. In histology showed rhabdomyosarcoma. A lobectomy performed following chemotherapy but recurrence not resectable at third thoracotomy. Ten patients cystic adenomatoid malformation,...
Background Atrial fibrillation (AF) is the most common cardiac arrhythmia in emergency department. The CHA 2 DS ‐VASc score helps to predict thromboembolic risk; however, rate of other adverse events more difficult predict. Hypothesis biomarker N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) has prognostic value patients presenting department with AF. Methods During a 1.5‐year period, prospective study was performed consecutive AF on electrocardiogram. At baseline, NT‐proBNP measured....
The first 1041 patients who underwent an isolated aorto-coronary bypass operation in the same institution since it opened 1971, were followed for up to 10 years determine their prognosis. mean follow-up time was 3.5 years. probability of survival at five 94 +/- 2% (95% confidence limits). This similar general Dutch population matched age and sex. Multivariate analysis with proportional hazards model did reveal a relationship rate death sex operation; however this not significant. There trend...