A5029221114- Bone health and treatments
- Bone and Joint Diseases
- Cancer Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Oral and gingival health research
- Salivary Gland Tumors Diagnosis and Treatment
- Oral health in cancer treatment
- Facial Trauma and Fracture Management
- Osteomyelitis and Bone Disorders Research
- Lung Cancer Treatments and Mutations
- Salivary Gland Disorders and Functions
- Infection Control and Ventilation
- Streptococcal Infections and Treatments
- Musculoskeletal synovial abnormalities and treatments
- Tumors and Oncological Cases
- COVID-19 and healthcare impacts
- Retinal and Optic Conditions
- Teratomas and Epidermoid Cysts
- Orthodontics and Dentofacial Orthopedics
- Craniofacial Disorders and Treatments
- Vascular Malformations and Hemangiomas
- Oral Health Pathology and Treatment
- Traumatic Ocular and Foreign Body Injuries
- Lung Cancer Diagnosis and Treatment
- Venomous Animal Envenomation and Studies
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2016-2018
This study investigated the incidence, risk factors, and outcome of medication-related osteonecrosis jaw after dental extractions in patients receiving antiresorptive agents for osteoporosis or bone metastases. 240 with a median drug exposure 43 months were retrospectively studied. The incidence MRONJ extraction cohort was 2.7 % per person-year (95 CI 1.6-4.6 %) (n = 13/126), metastases 26.4 20.4-34.2 58/114). 92 cases stage 1. Dental infection as reason increased (OR 22.77; 95 2.85-181.62;...
This observational case registry study was designed to describe the natural history of cancer patients with medication-related osteonecrosis jaw (ONJ) and evaluate ONJ resolution rate. Adults a diagnosis new were enrolled evaluated by dental specialist at baseline every 3 months for 2 years then 6 until death, consent withdrawal, or loss follow-up. The primary endpoint rate time course resolution. Secondary endpoints included frequency incident risk factors, treatment patterns, patterns...
Osteonecrosis of the jaw (ONJ) is a serious adverse event bone resorption inhibitors (BRIs), such as bisphosphonates and denosumab. Bisphosphonates denosumab inhibit osteoclast function through different pharmacological effects are retained in for several months to years. Sequential treatment with might lead an overlapping effect, due addition effect on residual bisphosphonate effect. Therefore, aim our study was investigate if switching from associated higher incidence ONJ.We...
To determine the impact of alveolar socket surface area and number root extractions for developing medication-related osteonecrosis jaw (MRONJ) in polypharmacy patients following multiple tooth extractions. A retrospective sample 40 was recruited, including 20 (109 extractions) who developed MRONJ at least one extraction sites, matched with controls (100 extractions). Tooth-specific areas were assessed using CBCT scans from control group to establish reference values MRONJ. Correlations...
There is currently no widespread strategy for treating medication-related osteonecrosis of the jaw (MRONJ), so our aim was to evaluate retrospectively outcome a minimally invasive treatment protocol patients with both MRONJ and cancer. We designed retrospective cohort study cancer who had been diagnosed after denosumab or bisphosphonates given intravenously. Primary measures were improvement in clinical stage time course its resolution. Secondary included incidence risk factors patterns...
BackgroundTo investigate the activity and safety of afatinib in preoperative treatment squamous cell carcinoma head neck (SCCHN).Patients methodsThis study was an open-label, randomized, multicenter, phase II window opportunity trial. Treatment-naïve SCCHN patients selected for primary curative surgery were randomized (5 : 1 ratio) to receive during 14 days (day –15 until day –1) before 0) or no treatment. Tumor biopsies, 2-[fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography...
Abstract Objective To attempt defining differential radiographic diagnostic characteristics for osteonecrotic lesions using 2D as opposed to 3D images. Materials and Methods This was a cross‐sectional study. Subjects presenting mandibular (osteomyelitis, osteoradionecrosis, medication‐related osteonecrosis of the jaws) were selected compared group age‐ gender‐matched controls, all having both cone‐beam computed tomographic images (CBCT) panoramic radiographs (PANO). Both imaging modalities...
ObjectiveThis study aimed to investigate the bacterial population in patients with medication-related osteonecrosis of jaw (MRONJ) after treatment doxycycline and metronidazole.Study DesignA total 38 MRONJ (age range 55-88, mean age 73 + 8.82 standard deviation) treated first metronidazole second were enrolled this study. Two swabs taken at margin infected lesion applying pressure on marginal mucosa, visible pus was secreted. Real-time polymerase chain reaction used analyze 20...
Objectives/Hypothesis Submandibular gland tumors (SMGTs) are rare and characterized by heterogeneity in histologic profiles. The aim of the present study was to retrieve data on submandibular (SMG) malignancies identify factors influencing survival. Study Design Retrospective study. Methods A multicenter, retrospective patients who underwent primary surgery for SMGTs at three referral centers performed. Results Among 204 with SMGTs, 50 (24.5%) SMG were analyzed detail. Definitive pT status...
Depending on the diagnostic modality, classification of vascular anomalies varies and so does nomenclature. The 'International Society for Study Vascular Anomalies' (ISSVA) is most widely accepted in literature mainly based radiologic clinical presentation. aim this article to review practice diagnosis treatment head neck region a university hospital, with special focus All patients anomaly presenting department oral maxillofacial surgery were reviewed retrospective manner. Nomenclature,...
The use of high quality facemasks is indispensable in the light current COVID pandemic. This study proposes a fully automatic technique to design face specific mask. Through stereophotogrammetry, computer-assisted and three-dimensional (3D) printing, we describe protocol for manufacturing perfectly adapted individual characteristics. mask was compared universal facemask different filter container’s designs were merged with body. Subjective assessment demonstrated tight closure at nose, mouth...
Lack of evidence existed related to the essential role by which anticancer medications alone or in combination with other polypharmacy would be accountable for wound healing impairment post-dental extraction. The following study was conducted assess influence antiresorptive (AR) and non-antiresorptive (non-AR) drugs patient-related risk factors on status tooth
6049 Background: Targeted agents (TA) are often investigated in unselected end-stage cancer patients (pts), making difficult to fully evaluate their activity and impairing translational research. One way resolve this issue is perform
This study was performed to introduce an in vivo hybrid multimodality technique involving the coregistration of micro-computed tomography (micro-CT) and high-resolution magnetic resonance imaging (HR-MRI) concomitantly visualize quantify mineralization vascularization at follow-up a rat model.Three adult female rats were randomly assigned as test subjects, with 1 serving control subject. For 20 weeks, received weekly intravenous injection 30 µg/kg zoledronic acid, administered similar dose...
Chondrocalcinosis is a non-infectious, inflammatory arthropathy which typically characterized by intra-articular deposition of calcium pyrophosphate dihydrate crystals. The occurrence chondrocalcinosis in the temporomandibular joint uncommon. This report describes case 51-year-old female with periarticular left joint. Disease progression and prolonged complaints pain limitation mouth opening were indications for surgical treatment. placement an alloprosthesis was performed simultaneously...
e21663 Background: Medication-related osteonecrosis of the jaw (MRONJ) is defined as exposed jawbone or bone that can be probed through a fistula, persisting for 8 more weeks. MRONJ occurs in absence radiation metastatic disease to jaws, and presence current previous antiresorptive antiangiogenic treatment (Ruggiero et al, 2014). This multicenter observational case registry advanced cancer patients (pts) with reports on natural history ONJ describes estimated rate time course resolution....