A5034134465- Amyotrophic Lateral Sclerosis Research
- COVID-19 Clinical Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Sleep and related disorders
- Alzheimer's disease research and treatments
- Prion Diseases and Protein Misfolding
- Cardiovascular Function and Risk Factors
- Bacterial Genetics and Biotechnology
- Biosimilars and Bioanalytical Methods
- Neurogenetic and Muscular Disorders Research
- Neutropenia and Cancer Infections
- Circadian rhythm and melatonin
- Intensive Care Unit Cognitive Disorders
- Sleep and Wakefulness Research
- Monoclonal and Polyclonal Antibodies Research
- Antimicrobial Resistance in Staphylococcus
- Stroke Rehabilitation and Recovery
- Supramolecular Self-Assembly in Materials
- Sepsis Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Membrane-based Ion Separation Techniques
- Escherichia coli research studies
- Orthopedic Infections and Treatments
- Tryptophan and brain disorders
Houston Methodist
2024
Emory University
2024
Princeton BioMeditech (United States)
2019-2024
University of California, Los Angeles
2005-2024
UCLA Health
2024
University of Pennsylvania
2020-2024
Aurora BayCare Medical Center
2022-2023
University of Michigan
2022-2023
Johns Hopkins Medicine
2019-2022
Johns Hopkins University
2019-2022
Automated cardiac image interpretation has the potential to transform clinical practice in multiple ways, including enabling serial assessment of function by nonexperts primary care and rural settings. We hypothesized that advances computer vision could enable building a fully automated, scalable analysis pipeline for echocardiogram interpretation, (1) view identification, (2) segmentation, (3) quantification structure function, (4) disease detection.Using 14 035 echocardiograms spanning...
The FDA has approved the clinical use of recombinant bone morphogenetic proteins (BMPs). However, BMPs in humans required large doses to be effective, which suggests that delivery method needs optimized. Gene therapy is an alternative deliver such proteins, and gene transfer techniques have been tested on a variety cell types including marrow cells, skin fibroblasts, peripheral blood monocytes, muscle-derived cells. In this study, we sought determine ability BMP-2-producing human...
To evaluate efficacy and safety of ramelteon (MT1/MT2-receptor [corrected] agonist) in subjects with chronic primary insomnia.
As part of an effort to examine the utility antibody–drug conjugates (ADCs) beyond oncology indications, a novel pyrophosphate ester linker was discovered enable targeted delivery glucocorticoids. small molecules, these highly soluble phosphate drug linkers were found have ideal orthogonal properties: robust plasma stability coupled with rapid release payload in lysosomal environment. Building upon findings, site-specific ADCs made between this combination and antibody against human CD70,...
Abstract Background Calcium release-activated calcium (CRAC) channel inhibitors stabilize the pulmonary endothelium and block proinflammatory cytokine release, potentially mitigating respiratory complications observed in patients with COVID-19. This study aimed to investigate safety efficacy of Auxora, a novel, intravenously administered CRAC inhibitor, adults severe or critical COVID-19 pneumonia. Methods A randomized, controlled, open-label Auxora was conducted Patients were randomized 2:1...
To assess the efficacy and safety of ramelteon, a selective melatonin MT1/MT2-receptor agonist, for insomnia treatment in older adults.In randomized, 9-week, 3-period crossover trial conducted at 17 sleep centers, adults (N = 100) with chronic primary (37 men, 63 women; mean age [range], 70.7 [65-83] years) were administered placebo, ramelteon 4 mg, 8 mg three phases two consecutive nights. Each phase was separated by 5- to 12-day washout periods. Sleep monitored via polysomnography....
Effective assessment and management of pain in patients with cancer is strengthened by the patient's report how much interferes daily functioning. This requires a clear delineation different levels interference. We derived optimal cutpoints for differentiating between mild, moderate, severe interference assessed Brief Pain Inventory (BPI) describe prevalence characteristics pain-induced functional impairment cancer. Data were pooled across 3 Phase III pivotal trials. Patient-completed...
Abstract Background In a Phase 3 study, amyotrophic lateral sclerosis (ALS) patients experienced significantly less physical functional decline with 24‐week edaravone vs placebo, followed by open‐label treatment for an additional 24 weeks. Methods Outcome (the change in ALS Functional Rating Scale–Revised, ALSFRS‐R, from baseline) was projected placebo through 48 weeks and compared 48‐week or after switching placebo. Results A total of 123 received (65 edaravone‐edaravone; 58...
Ammonia is considered a contaminant to be removed from wastewater. However, ammonia valuable commodity chemical used as the primary feedstock for fertilizer manufacturing. Here we describe simple and low-cost gas stripping membrane capable of recovering The material composed an electrically conducting porous carbon cloth coupled hydrophobic polypropylene support, that together form conductive (ECM). When cathodic potential applied ECM surface, hydroxide ions are produced at water-ECM...
Despite much effort, antibody therapies for Alzheimer’s disease (AD) have shown limited efficacy. Challenges to the rational design of effective antibodies include difficulty achieving specific affinity critical targets, poor expression, and aggregation caused by buried charges unstructured loops. To overcome these challenges, we grafted previously determined sequences fibril-capping amyloid inhibitors onto a camel heavy chain scaffold. These were designed cap fibrils tau, known form...
This observational case registry study was designed to describe the natural history of cancer patients with medication-related osteonecrosis jaw (ONJ) and evaluate ONJ resolution rate. Adults a diagnosis new were enrolled evaluated by dental specialist at baseline every 3 months for 2 years then 6 until death, consent withdrawal, or loss follow-up. The primary endpoint rate time course resolution. Secondary endpoints included frequency incident risk factors, treatment patterns, patterns...
A pan-caspase inhibitor, Q-VD-OPH, has therapeutic efficacy against preclinical methicillin-resistant Staphylococcus aureus skin infection.
Abstract Background Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. Methods CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, CRAC inhibitor, to corticosteroids standard care in adults Eligible were ≥ 1 symptom consistent infection, diagnosis confirmed by laboratory testing using...
Personality is an important aspect when deciding group dynamics. Depending on a person’s way of decision-making, or choice playstyle, this can change Final Fantasy game’s playthrough. For study, the playstyles X in Japan and United States were surveyed. This research involved using Hofstede’s cultural dimensions theoretical framework combined with Likert scale player responses. project aimed to show that individual decisions aligned choices expected predicted by...
Abstract In vivo bioluminescence imaging has been used to monitor Staphylococcus aureus infections in preclinical models by employing bacterial reporter strains possessing a modified lux operon from Photorhabdus luminescens . However, the relatively short emission wavelength of (peak 490 nm) limited tissue penetration. To overcome this limitation, gene for click beetle ( Pyrophorus plagiophtalamus ) red luciferase luc (with longer >600 wavelength), was introduced singly and combination...
Background Edaravone slowed the rate of functional decline in subjects with amyotrophic lateral sclerosis (ALS) phase 3 study MCI186-19 (Study 19). One Study 19 inclusion criteria was forced vital capacity (FVC) ≥80% predicted (≥80%p). Therefore, provided no information on edaravone efficacy FVC <80%p. In 19, 24-week, double-blind treatment followed by open-label where all received edaravone. At 24 weeks, some had <80%p (FVC <80%p). This allowed for post-hoc assessment effects...
Article AbstractObjective: To evaluate the long-term safety and subjective sleep effects of ramelteon in adults with chronic insomnia.Method: Subjects primary insomnia (DSM-IV-TR criteria) for ≥ 3 months received nightly 1 year; a 3-day placebo run out followed. aged 65 years open-label 8 mg (N = 248); those 18 to 64 16 965). completed diaries returned clinic at week 1, 2, 3, 4, 6, 8, 10, 12 assessments investigator-performed Clinical Global Impressions. The study was conducted from February...
Abstract In eukaryotes, linear motor proteins govern intracellular transport and organization. bacteria, where motors involved in spatial regulation are absent, the ParA/MinD family of ATPases organize an array genetic- protein-based cellular cargos. The positioning these cargos has been independently investigated to varying degrees several bacterial species. However, it remains unclear how multiple can coordinate diverse same cell. Here, we find that over a third sequenced genomes encode...
Background: Alzheimer’s disease (AD) is a progressive, multifactorial, neurodegenerative disorder affecting >6 million Americans. Chronic, low-grade neuroinflammation, and insulin resistance may drive AD pathogenesis. We explored the neurophysiological neuropsychological effects of NE3107, an oral, anti-inflammatory, insulin-sensitizing molecule, in AD. Methods: In this phase 2, open-label study, 23 patients with mild cognitive impairment or dementia received 20-mg oral NE3107 twice daily...
This experimental study consisted of four groups. In Group I, 8 animals were implanted with a collagen sponge containing 5 million human-derived bone marrow cells (HBMCs) infected the BMP-2-containing adenovirus. II, HBMCs, which had been an adenovirus cDNA for lacZ gene. III, uninfected HBMCs. IV, alone. All killed at 12 weeks.The purpose this was to assess ability HBMCs BMP-2 induce posterolateral spine in athymic rat model.High pseudarthrosis rates after attempted spinal arthrodesis as...