A5073971546- Ultrasound and Hyperthermia Applications
- Transcranial Magnetic Stimulation Studies
- Neurological disorders and treatments
- Optical Imaging and Spectroscopy Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Tryptophan and brain disorders
- Advanced MRI Techniques and Applications
- Laser Applications in Dentistry and Medicine
- Cervical Cancer and HPV Research
- Heart Rate Variability and Autonomic Control
- Alzheimer's disease research and treatments
- Genetic Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- Ultrasound Imaging and Elastography
- Neuroscience and Neural Engineering
- Head and Neck Cancer Studies
- Psychosomatic Disorders and Their Treatments
- Olfactory and Sensory Function Studies
- Cancer Diagnosis and Treatment
- Hemispheric Asymmetry in Neuroscience
- Oral health in cancer treatment
- Functional Brain Connectivity Studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Brain Tumor Detection and Classification
- Cancer-related cognitive impairment studies
University of California, Los Angeles
2020-2025
Synaptic Research (United States)
2019-2024
Fundación Chile
2024
Neurobehavioral Systems
2020-2024
VA Greater Los Angeles Healthcare System
2021-2023
Instituto Nacional del Cáncer
2009-2022
Ministry of Health
2019-2021
Child Neurology Associates
2021
Alliance Data (United States)
2020
Pacific Heart Institute
2020
Abstract Reconfigurable devices, whose shape can be drastically altered, are central to expandable shelters, deployable space structures, reversible encapsulation systems and medical tools robots. All these applications require structures actively controlled, both for deployment conform the surrounding environment. While most current reconfigurable designs application specific, here we present a mechanical metamaterial with tunable shape, volume stiffness. Our approach exploits simple...
Transcranial Focused Ultrasound (tFUS) is a promising new potential neuromodulation tool. However, the safety of tFUS has not yet been assessed adequately. Patients with refractory temporal lobe epilepsy electing to undergo an anterior resection present unique opportunity evaluate and efficacy neuromodulation. Histological changes in tissue after can be examined surgical resection, while further concerns using neuropsychological testing.Neuropsychological functions were eight patients before...
Background Low intensity, transcranial focused ultrasound (tFUS) is a re-emerging brain stimulation technique with the unique capability of reaching deep structures non-invasively. Objective/Hypothesis We sought to demonstrate that tFUS can selectively and accurately target modulate in humans important for emotional functioning as well learning memory. hypothesized would result significant longitudinal changes perfusion targeted region selective modulation BOLD activity BOLD-based functional...
Preclinical studies support investigation of focused ultrasound for breakdown cerebral pathologies in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's (PD).A transcranial Doppler device with probes (2 MHz, 520 mW/cm2) affixed bilaterally was used to target the hippocampus or substantia nigra (PD) functional magnetic resonance imaging navigation enhanced plaque removal. A total 22 patients (n = 11 AD, n PD) underwent 8 consecutive, weekly, 1-hour treatments...
This study intended to evaluate a possible therapeutic effect among patients with treatment-refractory generalized anxiety disorder (trGAD) by using transcranial focused ultrasound (tfUS) modulate amygdalar activity.
Objectives Exposure to art, nature, or meditation, all transcending human experiences, has beneficial effects on health and wellbeing. Focusing inward watching art nature videos elicits positive emotions that can help heal stress-related conditions. In a pilot functional magnetic resonance (fMRI) study, we explored the effect of digital compared contemplating universal connectedness (also known as transcendental meditation). The instructions were meditate connection Universal Soul linked...
Essential tremor (ET) can be debilitating. Treatments for ET include beta-blockers and surgical interventions. Low-intensity focused ultrasound (LIFU) may offer an office-based non-invasive alternative.
Background: Alzheimer’s disease (AD) is a progressive, multifactorial, neurodegenerative disorder affecting >6 million Americans. Chronic, low-grade neuroinflammation, and insulin resistance may drive AD pathogenesis. We explored the neurophysiological neuropsychological effects of NE3107, an oral, anti-inflammatory, insulin-sensitizing molecule, in AD. Methods: In this phase 2, open-label study, 23 patients with mild cognitive impairment or dementia received 20-mg oral NE3107 twice daily...
The amygdala is highly implicated in an array of psychiatric disorders but not accessible using currently available non-invasive neuromodulatory techniques. Low-intensity transcranial focused ultrasound (TFUS) a technique that capable reaching subcortical regions non-invasively. Healthy older adult participants (n = 21; ages 48-79) received TFUS targeting the right and left entorhinal cortex (active control region) two-visit within-participant crossover design. Before after TFUS, behavioral...
Background: This study sought to validate the clinical utility of multimodal magnetic resonance imaging (MRI) techniques in assessment neurodegenerative disorders. We intended demonstrate that advanced neuroimaging commonly used research can effectively be employed practice accurately differentiate heathy aging and dementia subtypes.Methods: Twenty patients with Alzheimer's type (DAT) 18 Parkinson's disease (PDD) were identified using gold-standard techniques. Twenty-three healthy, age sex...
Introduction: This study intended to evaluate the safety and possible therapeutic effect of transcranial infrared laser stimulation (TILS) based on photobiomodulation (PBM) among patients with traumatic brain injury (TBI). Methods: Eleven participants who were diagnosed TBI after full neurological examination MRI evaluation by a board-certified neurologist completed five eight 20-minute TILS sessions using Cytonsys CytonPro-5000 apparatus (pilot control, focused wavelength 1064 nm, maximum...
The pursuit of an effective therapeutic intervention for dementia has inspired interest in the class medications known as tyrosine kinase inhibitors such bosutinib.
Abstract Purpose The aim of this study was to assess the efficacy and safety Dentoxol mouthrinse in reducing severity oral mucositis (OM) secondary radiation therapy (RT) for head neck cancer. Methods A randomized, double-blind, placebo-controlled, multicenter phase II clinical trial conducted. Subjects were asked use ( n = 55) or control 53) 5 times/day during RT. Twice a week, OM assessed clinically using WHO scale Oral Mucositis Daily Questionnaire (OMDQ) completed. Results incidence...
The present study investigates a potential method of optimizing effective strategies for the functional lateralization dorsolateral prefrontal cortex (dlPFC) while in scanner. Effective hemisphere dlPFC is crucial lowering risks connected to specific interventions (such as neurosurgery and transcranial magnetic stimulation (TMS), well increasing effectiveness given intervention by figuring out optimal location. This task combines elements creative problem solving, executive decision making...
This study reports the results of a pilot program in Kenosha County that used combination direct biomarkers extracted from blood spots and nails to monitor repeat intoxicated drivers for their use alcohol drugs with detection window spanning 3 weeks several months. The objectives were test whether phosphatidylethanol (PEth), ethylglucuronide (EtG), 5 drug metabolites would (1) help assessors obtain more objective evaluation offenders during assessment interview, (2) allow timely...
ABSTRACT Objective Low-Intensity Focused Ultrasound Pulsations (LIFUP) is a promising new potential neuromodulation tool. However, the safety of LIFUP has not yet been adequately assessed. Patients with refractory temporal lobe epilepsy electing to undergo an anterior resection present unique opportunity evaluate and efficacy neuromodulation. Because brain tissue in these patients will be removed, histological changes after can examined. Evidence effective was assessed using functional MRI...
The concept "Biobank" is relatively new in the scientific literature, and not yet consensually defined, even for World Health Organization (WHO). However, use of human samples biomedical research a very old activity. organized development Biobanks different places has grown last decade. experience countries continents been diverse. In this special article we intend to summarize, organize communicate national medical community, (i) Biobank, (ii) international map Research working Chile, (iii)...
Colorectal (CRC) is one of the most common types cancer worldwide. Most tumors develop from an adenoma in a period 10 to 15 years, but some may appear without previous adenomatous lesions. Seventy-five percent colorectal cancers are sporadic, 20% have family component (first or second-degree relatives with CRC) and 5% hereditary predisposition Mendelian pattern. The epidemiological evolution recent years Chile has worrisome treatment costs advanced stages burden for healthcare system. We...
Choosing Wisely is an initiative by the American Board of Internal Medicine (ABIM) and ABIM Foundation to deter unnecessary medical treatments procedures. Faced with burden modern technologies treatments, it crucial identify practices lacking value in daily care. The Latin Caribbean Society (SLACOM), comprising cancer control experts, deems vital tailor this for enhancing care region. Through a modified DELPHI methodology involving two rounds electronic questionnaires hybrid meeting discuss...
The nucleus basalis (NBM) is the major source of cholinergic innervation to cerebral cortex, hippocampus and other subcortical structures. Focusing DTI fMRI on NBM can shed light potential state subjects with Alzheimer’s disease. We aim use provide insight into white matter projections from depict how it functionally wired. found that imaging differentiated dementia patients controls, captured level cognitive decline. While results are preliminary, this analysis introduces a method observing...
Survival rates after curative surgery for gastric cancer are disappointing. Therefore adjuvant therapeutic strategies required.To analyze survival and side effects of treatment among patients treated with chemo radiotherapy resection adenocarcinoma.Retrospective review medical records 74 aged 20 to years, complete adenocarcinoma followed by radiation. analysis was based on the information from National Mortality Registry.Five years fluctuated 50% in stage IB 25% those is IV. Significant...