A5030206822- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Psychosomatic Disorders and Their Treatments
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Neurobiology of Language and Bilingualism
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Vestibular and auditory disorders
- Cognitive Functions and Memory
- Epilepsy research and treatment
- Stroke Rehabilitation and Recovery
- Neurological disorders and treatments
- Attention Deficit Hyperactivity Disorder
- Heart Rate Variability and Autonomic Control
- Sleep and related disorders
- Healthcare Decision-Making and Restraints
- Musculoskeletal pain and rehabilitation
- Pain Management and Placebo Effect
- Cerebrospinal fluid and hydrocephalus
- Neurology and Historical Studies
- Mental Health and Psychiatry
- Paranormal Experiences and Beliefs
- Cerebral Palsy and Movement Disorders
Casa Colina Centers for Rehabilitation
2017-2025
Presbyterian Hospital
2024
New York Hospital Queens
2024
Columbia University
2024
NewYork–Presbyterian Hospital
2024
King's College London
2023
Moss Rehabilitation Hospital
2023
University of California, Los Angeles
2014-2022
Loyola Marymount University
2019-2020
Massachusetts General Hospital
2015-2020
Abstract Background Previously published studies have reported that up to 43% of patients with disorders consciousness are erroneously assigned a diagnosis vegetative state (VS). However, no recent investigated the accuracy this grave clinical diagnosis. In study, we compared consensus-based diagnoses VS and MCS those based on well-established standardized neurobehavioral rating scale, JFK Coma Recovery Scale-Revised (CRS-R). Methods We prospectively followed 103 (55 ± 19 years) mixed...
The ‘default network’ is defined as a set of areas, encompassing posterior-cingulate/precuneus, anterior cingulate/mesiofrontal cortex and temporo-parietal junctions, that show more activity at rest than during attention-demanding tasks. Recent studies have shown it possible to reliably identify this network in the absence any task, by resting state functional magnetic resonance imaging connectivity analyses healthy volunteers. However, significance these spontaneous brain fluctuations...
Mechanisms of anesthesia-induced loss consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation the level consciousness.Low-frequency spontaneous blood oxygen level-dependent fluctuations were measured in 19 healthy volunteers wakefulness, mild sedation, deep sedation with clinical unconsciousness, and subsequent recovery consciousness.Propofol-induced decrease linearly...
In perceptual experiments, within-individual fluctuations in perception are observed across multiple presentations of the same stimuli, a phenomenon that remains only partially understood. Here, by means thulium–yttrium/aluminum–garnet laser and event-related functional MRI, we tested whether variability identical stimuli relates to differences prestimulus, baseline brain activity. Results indicate positive relationship between conscious low-intensity somatosensory immediately preceding...
Discerning the neural correlates of (un)consciousness sheds light on mechanisms underlying vegetative states.
In humans, some evidence suggests that there are two different types of spindles during sleep, which differ by their scalp topography and possibly aspects regulation. To test for the existence spindle types, we characterized activity associated with slow (11–13 Hz) fast (13–15 spindles, identified as discrete events non-rapid eye movement in non-sleep-deprived human volunteers, using simultaneous electroencephalography functional MRI. An activation pattern common to both involved thalami,...
<h3>Background</h3> A major challenge in the management of severely brain-injured patients with altered states consciousness is to estimate their residual perception environment. <h3>Objective</h3> To investigate integrity detection one's own name a behaviorally well-documented vegetative state (VS), minimally conscious (MCS), and locked-in syndrome. <h3>Design</h3> We recorded auditory evoked potentials patient's 7 other equiprobable first names 15 brain-damaged patients. <h3>Results</h3>...
<b>Background: </b> Disentangling the vegetative state from minimally conscious is often difficult when relying only on behavioral observation. In this study, we explored a new active evoked-related potentials paradigm as an alternative method for detection of voluntary brain activity. <b>Methods: The participants were 22 right-handed patients (10 traumatic) diagnosed being in (VS) (n = 8) or (MCS) 14). They presented sequences names containing patient’s own name other names, both passive...
Recent advances in functional neuroimaging have demonstrated novel potential for informing diagnosis and prognosis the unresponsive wakeful syndrome minimally conscious states. However, these technologies come with considerable expense difficulty, limiting possibility of wider clinical application patients. Here, we show that high density electroencephalography, collected from 104 patients measured at rest, can provide valuable information about brain connectivity correlates behaviour...
Assessing behavioral responses to nociception is difficult in severely brain-injured patients recovering from coma. We here propose a new scale developed for assessing vegetative (VS) and minimally conscious (MCS) coma survivors, the Nociception Coma Scale (NCS), explore its concurrent validity, inter-rater agreement sensitivity. Concurrent validity was assessed by analyzing of 48 post-comatose noxious stimulation (pressure applied fingernail) (28 VS 20 MCS; age range 20-82 years; 17...
Total locked-in syndrome is characterized by tetraplegia, anarthria and paralysis of eye motility. In this study, consciousness was detected in a 21-year-old woman who presented total after basilar artery thrombosis (49 days post-injury) using an active event-related paradigm. The patient sequences names containing the patient's own name other names. instructed to count her or another target name. Similar 4 age- gender-matched healthy controls, P3 response recorded for voluntarily counted...
Primary objective: The aim of the present study was to explore concurrent validity, inter-rater agreement and diagnostic sensitivity a French adaptation Coma Recovery Scale–Revised (CRS-R) as compared other coma scales such Glasgow Scale (GCS), Full Outline UnResponsiveness scale (FOUR) Wessex Head Injury Matrix (WHIM).Research design: Multi-centric prospective study.Method procedures: To test validity sensitivity, four behavioural were administered in randomized order 77 vegetative...
The existence of normal sleep in patients a vegetative state is still matter debate. Previous electrophysiological studies with disorders consciousness did not differentiate from minimally conscious state. Using high-density electroencephalographic recordings, 11 (six state, five state) were studied to correlate the changes associated behavioural vigilance (sustained eye closure and muscle inactivity). All showed clear decreases vigilance. In showing sustained periods, we identified several...