A5042265881- Anesthesia and Sedative Agents
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Traumatic Brain Injury and Neurovascular Disturbances
- Nausea and vomiting management
- Airway Management and Intubation Techniques
- Optical Imaging and Spectroscopy Techniques
- Intensive Care Unit Cognitive Disorders
- Obstructive Sleep Apnea Research
- Hemodynamic Monitoring and Therapy
- Spine and Intervertebral Disc Pathology
- Plant Reproductive Biology
- Pain Management and Placebo Effect
- Pediatric Pain Management Techniques
- Pain Management and Opioid Use
- Musculoskeletal pain and rehabilitation
- Neuroscience of respiration and sleep
- Analytical Chemistry and Sensors
- Epilepsy research and treatment
- Respiratory Support and Mechanisms
- Sleep and Wakefulness Research
University of Liège
2016-2025
Imation (United States)
2021-2025
Centre Hospitalier Universitaire de Liège
2015-2024
Institut des Sciences de l'Evolution de Montpellier
2022-2024
Royal Prince Alfred Hospital
2024
Radboud University Nijmegen
2024
Radboud University Medical Center
2024
Joint Research Center
2024
Centre hospitalier régional de la Citadelle
2014-2023
Cliniques Universitaires Saint-Luc
2023
Mechanisms of anesthesia-induced loss consciousness remain poorly understood. Resting-state functional magnetic resonance imaging allows investigating whole-brain connectivity changes during pharmacological modulation the level consciousness.Low-frequency spontaneous blood oxygen level-dependent fluctuations were measured in 19 healthy volunteers wakefulness, mild sedation, deep sedation with clinical unconsciousness, and subsequent recovery consciousness.Propofol-induced decrease linearly...
In the present study, we used positron emission tomography to investigate changes in regional cerebral blood flow (rCBF) during a general anesthetic infusion set produce gradual transition from awake state unconsciousness. Five right-handed human volunteers participated study. They were given propofol with computer-controlled pump achieve three stable levels of plasma concentrations corresponding mild sedation, deep and unconsciousness, latter defined as unresponsiveness verbal commands....
The mechanisms underlying anesthesia-induced loss of consciousness remain a matter debate. Recent electrophysiological reports suggest that while initial propofol infusion provokes an increase in fast rhythms (from beta to gamma range), slow activity delta alpha range) rises selectively during consciousness. Dynamic causal modeling was used investigate the neural mediating these changes spectral power humans. We analyzed source-reconstructed data from frontal and parietal cortices normal...
Loss of cortical integration and changes in the dynamics electrophysiological brain signals characterize transition from wakefulness towards unconsciousness. In this study, we arrive at a basic model explaining these observations based on theory phase transitions complex systems. We studied link between spatial temporal correlations large-scale activity recorded with functional magnetic resonance imaging during wakefulness, propofol-induced sedation loss consciousness subsequent recovery....
Abstract Background Consciousness-altering anesthetic agents disturb connectivity between brain regions composing the resting-state consciousness networks (RSNs). The default mode network (DMn), executive control network, salience (SALn), auditory sensorimotor (SMn), and visual sustain mentation. Ketamine modifies differently from other agents, producing psychedelic dreaming no apparent interaction with environment. authors used functional magnetic resonance imaging to explore...
Consciousness can be defined by two components: arousal (wakefulness) and awareness (subjective experience). However, neurophysiological consciousness metrics able to disentangle between these components have not been reported. Here, we propose an explainable indicator (ECI) using deep learning the of consciousness. We employ electroencephalographic (EEG) responses transcranial magnetic stimulation under various conditions, including sleep (n = 6), general anesthesia 16), severe brain injury...
In this functional magnetic resonance imaging study, we examined the effect of mild propofol sedation and propofol-induced unconsciousness on resting state brain connectivity, using graph analysis based independent component a classical seed-based analysis. Contrary to previous research, which mainly emphasized importance connectivity in default mode network (DMN) external control (ECN), focused salience network, thalamus, brainstem. The these regions arousal organization merits more...
Background Recent studies have been shown that functional connectivity of cerebral areas is not a static phenomenon, but exhibits spontaneous fluctuations over time. There evidence fluctuating an intrinsic phenomenon brain dynamics persists during anesthesia. Lately, point process analysis applied on data has revealed much the information regarding contained in fraction critical time points resting state dataset. In present study we want to extend this methodology for investigation fMRI...
The isolated forearm technique allows assessment of consciousness the external world (connected consciousness) through a verbal command to move hand (of tourniquet-isolated arm) during intended general anesthesia. Previous data suggest that incidence connected may approach 37% after noxious stimulus. authors conducted an international, multicenter, pragmatic study establish responsiveness intubation in routine practice.Two hundred sixty adult patients were recruited at six sites into...
A key feature of the human brain is its capability to adapt flexibly changing external stimuli. This can be eliminated by general anesthesia, a state characterized unresponsiveness, amnesia, and (most likely) unconsciousness. Previous studies demonstrated decreased connectivity within thalamus, frontoparietal, default mode networks during anesthesia. We hypothesized that these alterations specific lead change communication between their temporal dynamics.We conducted pooled spatial...
General anesthesia reversibly alters consciousness, without shutting down the brain globally. Depending on anesthetic agent and dose, it may produce different consciousness states including a complete absence of subjective experience (unconsciousness), conscious perception environment (disconnected like during dreaming), or episodes oriented with awareness (connected consciousness). Each state potentially be followed by explicit implicit memories after procedure. In this respect, can...
Consciousness transiently fades away during deep sleep, more stably under anesthesia, and sometimes permanently due to brain injury. The development of an index quantify the level consciousness across these different states is regarded as a key problem both in basic clinical neuroscience. We argue that this ill-defined since such would not exhaust all relevant information about given state consciousness. While can be taken describe actual state, complete characterization should also include...
To understand how pharmacological interventions can exert their powerful effects on brain function, we need to they engage the brain's rich neurotransmitter landscape. Here, bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating regional distribution of 19 receptors transporters obtained from positron emission tomography, changes in magnetic resonance imaging connectivity 10 different mind-altering drugs: propofol,...
Background It is postulated that alteration of central cholinergic transmission plays an important role in the mechanism by which anesthetics produce unconsciousness. The authors investigated effect altering transmission, physostigmine and scopolamine, on unconsciousness produced propofol. Methods Propofol was administered to American Society Anesthesiologists physical status 1 (n = 17) volunteers with use a computer-controlled infusion pump at increasing concentrations until resulted...
Summary The effects of intra‐operative magnesium sulphate on pain relief after major lumbar surgery were investigated in 24 patients. Patients randomly allocated to receive either an infusion 50 mg.kg −1 or equivalent volume saline at induction anaesthesia. Anaesthesia was induced with propofol and remifentanil. Tracheal intubation facilitated using rocuronium. Maintenance achieved remifentanil sevoflurane nitrous oxide/ oxygen. Intra‐operative monitoring included standard equipment...
We describe the target‐controlled administration of propofol and remifentanil, combined with monitoring bispectral index, during an awake craniotomy for removal a left temporo‐parietal tumour near motor speech centre. Target concentrations two drugs were adjusted according to patient's responses painful stimuli surgical events, need testing. Allowing effect‐site remifentanil decrease surgery allowed performance cortical mapping testing ability speak. Although index was not used as guide...