A5072076176- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Psychosomatic Disorders and Their Treatments
- Neural dynamics and brain function
- Anesthesia and Sedative Agents
- Transcranial Magnetic Stimulation Studies
- Autoimmune Neurological Disorders and Treatments
- Epilepsy research and treatment
- Cognitive Functions and Memory
- Anesthesia and Neurotoxicity Research
- Atomic and Subatomic Physics Research
- Suicide and Self-Harm Studies
- Sleep and Wakefulness Research
- Advanced Neuroimaging Techniques and Applications
- Mitochondrial Function and Pathology
- Neural and Behavioral Psychology Studies
- Acute Ischemic Stroke Management
- Histiocytic Disorders and Treatments
- Brain Tumor Detection and Classification
- Hematological disorders and diagnostics
- Evolutionary Algorithms and Applications
- Neuroscience and Neuropharmacology Research
University of Liège
2016-2025
Centre Hospitalier Universitaire de Liège
2014-2023
Cyclotron (Netherlands)
2014
Fund for Scientific Research
2014
Validating objective, brain-based indices of consciousness in behaviorally unresponsive patients represents a challenge due to the impossibility obtaining independent evidence through subjective reports. Here we address this problem by first validating promising metric consciousness-the Perturbational Complexity Index (PCI)-in benchmark population who could confirm presence or absence reports, and then applying same index with disorders (DOCs).The encompassed 150 healthy controls...
Consciousness can be defined by two components: arousal (wakefulness) and awareness (subjective experience). However, neurophysiological consciousness metrics able to disentangle between these components have not been reported. Here, we propose an explainable indicator (ECI) using deep learning the of consciousness. We employ electroencephalographic (EEG) responses transcranial magnetic stimulation under various conditions, including sleep (n = 6), general anesthesia 16), severe brain injury...
Making an accurate diagnosis in patients with disorders of consciousness remains challenging. 18F-fluorodeoxyglucose (FDG)–PET has been validated as a diagnostic tool this population, and allows identifying unresponsive capacity for consciousness. In parallel, the perturbational complexity index (PCI), new measure based on analysis electroencephalographic response to transcranial magnetic stimulation, also suggested distinguish between unconscious conscious states. The aim study was...
Abstract Unresponsive wakefulness syndrome (UWS) patients may retain intact portions of the thalamocortical system that are spontaneously active and reactive to sensory stimuli but fail engage in complex causal interactions, resulting loss consciousness. Here, we show brain complexity after severe injuries is due a pathological tendency cortical circuits fall into silence (OFF-period) upon receiving an input, behavior typically observed during sleep. Spectral phase domain analysis EEG...
General anesthesia reversibly alters consciousness, without shutting down the brain globally. Depending on anesthetic agent and dose, it may produce different consciousness states including a complete absence of subjective experience (unconsciousness), conscious perception environment (disconnected like during dreaming), or episodes oriented with awareness (connected consciousness). Each state potentially be followed by explicit implicit memories after procedure. In this respect, can...
The Coma Recovery Scale-Revised (CRS-R) is the gold standard to assess severely brain-injured patients with prolonged disorders of consciousness (DoC). However, amount time needed complete this examination may limit its use in clinical settings.We aimed validate a new faster tool individuals DoC.This prospective validation study introduces Simplified Evaluation CONsciousness Disorders (SECONDs), composed 8 items: arousal, localization pain, visual fixation, pursuit, oriented behaviors,...
Abstract Neurophysiological markers can overcome the limitations of behavioural assessments Disorders Consciousness (DoC). EEG alpha power emerged as a promising marker for DoC, although long-standing literature reported being sustained during anesthetic-induced unconsciousness, and reduced dreaming hallucinations. We hypothesized that suppression caused by severe anoxia could explain this conflict. Accordingly, we split DoC patients (n = 87) in postanoxic non-postanoxic cohorts. Alpha was...
Different behavioural signs of consciousness can distinguish patients with an unresponsive wakefulness syndrome from in minimally conscious state (MCS). The Coma Recovery Scale-Revised (CRS-R) is the most sensitive scale to differentiate different altered states and eleven items detect MCS. aim this study document prevalence these items. We analysed assessments 282 diagnosed MCS based on CRS-R. Results showed that some are particularly frequent among MCS, namely fixation, visual pursuit,...
Survivors of severe brain injuries may end up in a state ‘wakeful unresponsiveness’ or minimally conscious state. Pharmacological treatments patients with disorders consciousness aim to improve arousal levels and recovery consciousness. We here provide systematic overview the therapeutic effects amantadine, apomorphine zolpidem recovering from coma. Evidence clinical trials using these commonly prescribed pharmacological agents suggests positive changes patients’ neurological status, leading...
Transcranial magnetic stimulation (TMS) in combination with neuroimaging techniques allows to measure the effects of a direct perturbation brain. When coupled high-density electroencephalography (TMS/hd-EEG), TMS pulses revealed electrophysiological signatures different cortical modules health and disease. However, neural underpinnings these remain unclear. Here, by applying multimodal analyses response recordings diffusion resonance imaging (dMRI) tractography, we investigated relationship...
Establishing an accurate diagnosis is crucial for patients with disorders of consciousness (DoC) following a severe brain injury. The Coma Recovery Scale-Revised (CRS-R) the recommended behavioral scale assessing level among these patients, but its long duration administration major hurdle in clinical settings. Simplified Evaluation CONsciousness Disorders (SECONDs) shorter that was developed to tackle this issue. It consists six mandatory items (observation, command-following, visual...
Establishing an accurate diagnosis is crucial for patients with disorders of consciousness (DoC) following a severe brain injury. The Coma Recovery Scale-Revised (CRS-R) the recommended behavioral scale assessing level among these patients, but its long duration administration major hurdle in clinical settings. Simplified Evaluation CONsciousness Disorders (SECONDs) shorter that was developed to tackle this issue. It consists six mandatory items (observation, command-following, visual...
Cryogenic magnetoencephalography (MEG) has a lower yield in temporal lobe epilepsy (TLE) than extra-TLE (ETLE). The advent of optically pumped magnetometers (OPMs) might change this thanks to on-scalp MEG, which allows sensors be placed closer the brain and design bespoke sensor arrays target specific regions. This study aims investigate detection localization accuracy interictal epileptiform discharges (IEDs) using MEG TLE added-value face-OPMs for IED detection/localization. Eleven...
A number of recent studies suggest that some 'vegetative state' patients have been misdiagnosed, judging by their ability to follow commands and in cases even communicate through brain activity. Such highlight the difficulty forming a diagnosis based only on behavioral assessments. We think neuroimaging electrophysiology methods will be used more frequently clinical settings, integrated with existing efforts are expected lead accurate understanding individual patients' cognitive abilities or...
Due to life-saving medical advances, the diagnosis and treatment of disorders consciousness (DOC) has become a more commonly occurring clinical issue. One recently developed intervention option been non-invasive transcranial direct current stimulation. This dichotomy patient responders may be better understood by investigating mechanism behind stimulation (tDCS) intervention. The combination magnetic electroencephalography (TMS-EEG) an important diagnostic tool in DOC patients. We therefore...