A5001943118- Functional Brain Connectivity Studies
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced Neuroimaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- EEG and Brain-Computer Interfaces
- Heart Rate Variability and Autonomic Control
- Transcranial Magnetic Stimulation Studies
- Cardiac Arrest and Resuscitation
- Multiple Sclerosis Research Studies
- RNA regulation and disease
- Fetal and Pediatric Neurological Disorders
- Neural dynamics and brain function
- Dementia and Cognitive Impairment Research
- Neonatal and fetal brain pathology
- MRI in cancer diagnosis
- DNA Repair Mechanisms
- Medical Image Segmentation Techniques
- Neurological Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Prenatal Screening and Diagnostics
- RNA and protein synthesis mechanisms
- Spaceflight effects on biology
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Amsterdam Neuroscience
2024
Vrije Universiteit Amsterdam
2024
IRCCS Istituto Auxologico Italiano
2024
University of Edinburgh
2017-2022
Edinburgh College
2022
University of Liège
2013-2021
UK Dementia Research Institute
2017-2021
Klinikum rechts der Isar
2019
Centre Hospitalier Universitaire de Liège
2016-2018
Despite advances in resting state functional magnetic resonance imaging investigations, clinicians remain with the challenge of how to implement this paradigm on an individualized basis. Here, we assessed clinical relevance acquisitions patients disorders consciousness by means a systems-level approach. Three centres collected data from 73 minimally conscious state, vegetative state/unresponsive wakefulness syndrome and coma. The main analysis was performed set coming one centre (Liège)...
To date, hampered physiological function after exposure to microgravity has been primarily attributed deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain long-duration spaceflight. More specifically, we found significant differences resting-state functional connectivity between motor cortex and cerebellum, as well changes within default mode network. In addition, cosmonaut showed supplementary areas during a imagery task. These...
Background Recent studies have been shown that functional connectivity of cerebral areas is not a static phenomenon, but exhibits spontaneous fluctuations over time. There evidence fluctuating an intrinsic phenomenon brain dynamics persists during anesthesia. Lately, point process analysis applied on data has revealed much the information regarding contained in fraction critical time points resting state dataset. In present study we want to extend this methodology for investigation fMRI...
A key feature of the human brain is its capability to adapt flexibly changing external stimuli. This can be eliminated by general anesthesia, a state characterized unresponsiveness, amnesia, and (most likely) unconsciousness. Previous studies demonstrated decreased connectivity within thalamus, frontoparietal, default mode networks during anesthesia. We hypothesized that these alterations specific lead change communication between their temporal dynamics.We conducted pooled spatial...
Abstract Background We classified non‐demented European Prevention of Alzheimer's Dementia (EPAD) participants through the amyloid/tau/neurodegeneration (ATN) scheme and assessed their neuropsychological imaging profiles. Materials methods From 1500 EPAD participants, 312 were excluded. Cerebrospinal fluid cut‐offs 1000 pg/mL for amyloid beta (Aß)1‐42 27 p‐tau181 validated using Gaussian mixture models. Given strong correlation p‐tau t‐tau (R 2 = 0.98, P < 0.001), neurodegeneration was...
OBJECTIVE Deep brain stimulation of the thalamus was introduced more than 40 years ago with objective improving performance and attention patients in a vegetative or minimally conscious state. Here, authors report results Cortical Activation by Thalamic Stimulation (CATS) study, prospective multiinstitutional study on effects bilateral chronic anterior intralaminar thalamic nuclei adjacent paralaminar regions affected disorder consciousness. METHODS The evaluated clinical radiological data...
Purpose To assess whether early brain functional connectivity is associated with recovery 1 year after cardiac arrest (CA). Materials and Methods Enrolled in this prospective multicenter cohort were 46 patients who comatose CA. Principal outcome was cerebral performance category at 12 months, favorable (FO) defined as or 2. All participants underwent multiparametric structural magnetic resonance (MR) imaging less than 4 weeks Within- between-network measured dorsal attention network (DAN),...
Given that recent research has shown functional connectivity is not a static phenomenon, we aim to investigate the dynamic properties of default mode network's (DMN) in patients with disorders consciousness.Resting-state fMRI volumes convenience sample 17 unresponsive wakefulness syndrome (UWS) and controls were reduced spatiotemporal point process by selecting critical time points posterior cingulate cortex (PCC). Spatial clustering was performed on extracted PCC frames obtain 8 different...
<h3>Objective</h3> The psoriatic arthritis (PsA) core domain set for randomized controlled trials (RCTs) and longitudinal observational studies (LOS) has recently been updated. joint counts are central to the measurement of peripheral component musculoskeletal (MSK) disease activity domain. We report Outcome Measures in Rheumatology (OMERACT) 2018 meeting approaches seek endorsement 66/68-swollen tender count (SJC66/TJC68) inclusion PsA Core Measurement Set. <h3>Methods</h3> Using OMERACT...
Previous studies have shown the prognostic value of stimulation elicited blood-oxygen-level-dependent (BOLD) signal in traumatic patients vegetative state/unresponsive wakefulness syndrome (VS/UWS). However, to best our knowledge, no focused on relevance etiology and level consciousness with disorders (DOC) when explaining relationship between BOLD both outcome variability. We herein propose a study large sample non-traumatic DOC order ascertain variability stimulation-elicited signal. 66...
The relationship between residual brain tissue in patients with disorders of consciousness (DOC) and the clinical condition is unclear. This observational study aimed to quantify gray (GM) white matter (WM) atrophy states (altered) consciousness.Structural T1-weighted magnetic resonance images were processed for 102 severely brain-injured 52 healthy subjects. Regional volume was quantified 158 (sub)cortical regions using Freesurfer. regional characteristics DOC conscious assessed a linear...
Background Disorders of consciousness are challenging to diagnose, with inconsistent behavioural responses, motor and cognitive disabilities, leading approximately 40% misdiagnoses. Heart rate variability (HRV) reflects the complexity heart-brain two-way dynamic interactions. HRV entropy analysis quantifies unpredictability heart beats intervals. We here investigate index (CI), a score by aggregating non-linear multi-scale entropies over range time scales, its discriminative power in chronic...
Abstract A vast body of literature exists showing functional and structural dysfunction within the brains patients with disorders consciousness. However, function (fluorodeoxyglucose FDG‐PET metabolism)–structure (MRI‐diffusion‐weighted images; DWI) relationship how it is affected in severely brain injured remains ill‐defined. MRI‐DWI 25 (19 Disorders Consciousness which 7 unresponsive wakefulness syndrome, 12 minimally conscious; 6 emergence from conscious state) healthy control subjects...
To reduce head movement during resting state functional magnetic resonance imaging, post-coma patients with disorders of consciousness (DOC) are frequently sedated propofol. However, little is known about the effects this sedation on brain connectivity patterns in damaged essential for differential diagnosis. In study, we aimed to assess these effects.Using imaging 3T data obtained over several years scanning diagnostic and research purposes, employed a seed-based approach examine...
Abstract Introduction The mildly invasive 18F‐fluorodeoxyglucose positron emission tomography ( FDG ‐ PET ) is a well‐established imaging technique to measure ‘resting state’ cerebral metabolism. This made it possible assess changes in metabolic activity clinical applications, such as the study of severe brain injury and disorders consciousness. Objective We assessed possibility creating functional MRI maps, which could estimate relative levels maps. If no absolute measures can be extracted,...
The European Prevention of Alzheimer Dementia (EPAD) is a multi-center study that aims to characterize the preclinical and prodromal stages Alzheimer's Disease. EPAD imaging dataset includes core (3D T1w, 3D FLAIR) advanced (ASL, diffusion MRI, resting-state fMRI) MRI sequences. Here, we give an overview semi-automatic multimodal multisite pipeline developed curate, preprocess, quality control (QC), compute image-derived phenotypes (IDPs) from dataset. This harmonizes DICOM data structure...
Vascular risk factors (VRFs) and cerebral small vessel disease (cSVD) are common in patients with Alzheimer (AD). It remains unclear whether this coexistence reflects shared or a mechanistic relationship vascular amyloid pathologies have independent synergistic influence on subsequent AD pathophysiology preclinical stages. We investigated links between VRFs, cSVD, levels (Aβ1-42) their combined effect downstream biomarkers, that is, CSF hyperphosphorylated tau (P-tau181), atrophy, cognition....