A5038894547- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiomyopathy and Myosin Studies
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Radiomics and Machine Learning in Medical Imaging
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Coronary Interventions and Diagnostics
- MRI in cancer diagnosis
- Cardiac Valve Diseases and Treatments
- Functional Brain Connectivity Studies
- Spaceflight effects on biology
- Congenital Heart Disease Studies
- Cerebrovascular and Carotid Artery Diseases
- Viral Infections and Immunology Research
- Cardiac Structural Anomalies and Repair
- Cardiovascular Effects of Exercise
- COVID-19 Clinical Research Studies
- Acute Myocardial Infarction Research
- Cardiac tumors and thrombi
- Pericarditis and Cardiac Tamponade
- Meningioma and schwannoma management
- Cardiovascular Disease and Adiposity
Moscow State University
2018-2025
Lomonosov Moscow State University
2018-2025
City Clinical Hospital
2017-2024
Russian Research Center for Molecular Diagnostics and Therapy
2023-2024
City Hospital
2024
Medical Technologies (Czechia)
2020-2022
Russian Medical Academy of Continuous Professional Education
2018-2019
Ministry of Health of the Russian Federation
2003-2019
State Scientific Center of the Russian Federation - Federal Medical Biophysical Center named after A.I. Burnazyan
2017
Nikiforov Russian Center of Emergency and Radiation Medicine
2017
The aim was to validate, update, and extend the Diamond–Forrester model for estimating probability of obstructive coronary artery disease (CAD) in a contemporary cohort. Prospectively collected data from 14 hospitals on patients with chest pain without history CAD referred conventional angiography (CCA) were used. Primary outcome CAD, defined as ≥50% stenosis one or more vessels CCA. validity assessed using calibration plots, calibration-in-the-large, recalibration logistic regression....
<b>Objectives</b> To develop prediction models that better estimate the pretest probability of coronary artery disease in low prevalence populations. <b>Design </b>Retrospective pooled analysis individual patient data. <b>Setting </b>18 hospitals Europe and United States. <b>Participants</b> Patients with stable chest pain without evidence for previous disease, if they were referred computed tomography (CT) based angiography or catheter (indicated as high settings, respectively). <b>Main...
The coronavirus disease 2019 (COVID-19) pandemic has adversely affected diagnosis and treatment of noncommunicable diseases. Its effects on delivery diagnostic care for cardiovascular disease, which remains the leading cause death worldwide, have not been quantified.The study sought to assess COVID-19's impact global procedural volumes safety practices.The International Atomic Energy Agency conducted a worldwide survey assessing alterations in procedure practices resulting from COVID-19....
Postflight changes in muscle volume, calf transverse relaxation time, and total body composition were measured 4 crewmembers after a 17-day mission 14–16 multiple shuttle/Mir missions of 16- to 28-wk duration. During the mission, all regions except hamstrings significantly decreased 3–10% compared with baseline. missions, there significant decreases volume (5–17%) groups neck. These changes, which reached new steady state by mo flight or less, reversed within 30–60 days landing. swelling...
Recent clinical trials have suggested that intensive versus standard lipid-lowering therapy provides for additional benefit. Electron-beam computed tomography the opportunity to quantify progression of coronary artery calcification (CAC) in serial measurements.In a multicenter, randomized, double-blind trial, 471 patients (age 61+/-8 years) who had no history disease and evidence high-grade stenoses (>50% diameter reduction) were randomized if they > or =2 cardiovascular risk factors...
To date, hampered physiological function after exposure to microgravity has been primarily attributed deprived peripheral neuro-sensory systems. For the first time, this study elucidates alterations in human brain long-duration spaceflight. More specifically, we found significant differences resting-state functional connectivity between motor cortex and cerebellum, as well changes within default mode network. In addition, cosmonaut showed supplementary areas during a imagery task. These...
Significance Long-duration spaceflight induces detrimental changes in human physiology due to microgravity. One example is a cephalic fluid shift. Here, we prospectively investigated the quantitative cerebrospinal (CSF) volume of brain ventricular regions space crew by means region interest, observer-independent analysis on structural MRI scans. scans were collected before mission, shortly after and 7 mo return Earth. We found significant increase lateral third ventricles at postflight trend...
The present study reports alterations of task-based functional brain connectivity in a group 11 cosmonauts after long-duration spaceflight, compared to healthy control not involved the space program. To elicit postural and locomotor sensorimotor mechanisms that are usually most significantly impaired when travelers return Earth, plantar stimulation paradigm was used block design fMRI study. motor system activated by precentral postcentral gyri, SMA, SII/operculum, and, lesser degree, insular...
Spaceflight causes persisting sensorimotor neuroplasticity and reversible gray matter morphological changes.
Background There is lack of guidance on specific CT protocols for imaging patients with coronavirus disease 2019 (COVID-19) pneumonia. Purpose To assess international variations in utilization, protocols, and radiation doses COVID-19 Materials Methods In this retrospective data collection study, the International Atomic Energy Agency coordinated a survey between May July 2020 regarding from 62 health care sites 34 countries across five continents examinations performed The questionnaire...
Long-duration spaceflight induces changes to the brain and cerebrospinal fluid compartments visual acuity problems known as spaceflight-associated neuro-ocular syndrome (SANS). The clinical relevance of these whether they equally affect crews different space agencies remain unknown. We used MRI analyze alterations occurring in perivascular spaces (PVS) NASA European Space Agency astronauts Roscosmos cosmonauts after a 6-mo on International Station (ISS). found increased volume basal ganglia...
Introduction Coronavirus pneumonia not only severely affects the lung tissue but is also associated with systemic autoimmune inflammation, rapid overactivation of cytokines and chemokines known as “cytokine storm”, a high risk thrombosis thromboembolism. Since there no specific therapy for this new coronavirus infection (COVID-19), searching an effective safe anti-inflammatory critical. Materials methods This study evaluated efficacy safety pulse doses glucocorticosteroids (GCS),...
Actuality The course of the novel coronavirus disease (COVID-19) is unpredictable. It manifests in some cases as increasing inflammation to even onset a cytokine storm and irreversible progression acute respiratory syndrome, which associated with risk death patients. Thus, proactive anti-inflammatory therapy remains an open serious question patients COVID-19 pneumonia, who still have signs on days 7-9 disease: elevated C-reactive protein (CRP)>60 mg/dL at least two four clinical signs:...
The extent to which health care systems have adapted the COVID-19 pandemic provide necessary cardiac diagnostic services is unknown. aim of this study was determine impact on testing practices, volumes and types services, perceived psychological stress providers worldwide. International Atomic Energy Agency conducted a worldwide survey assessing alterations from baseline in cardiovascular at pandemic's onset 1 year later. Multivariable regression used factors associated with procedure volume...
Here, we present a small Russian family, where the index patient received diagnosis of left-ventricular non-compaction cardiomyopathy (LVNC) in combination with skeletal myopathy. Clinical follow-up analysis revealed LVNC phenotype also her son. Therefore, applied broad next-generation sequencing gene panel approach for identification underlying mutation. Interestingly, DES-p.A337P was identified genomes both patients, whereas only carried DSP-p.L1348X. DES encodes muscle-specific...
Humans undergo extreme physiological changes when subjected to long periods of weightlessness, and as we continue become a space-faring species, it is imperative that fully understand the occur in human body, including brain. In this study, present findings brain structural associated with long-duration spaceflight based on diffusion magnetic resonance imaging (dMRI) data. Twelve cosmonauts who spent an average six months aboard International Space Station (ISS) were scanned MRI scanner...
The prospect of continued manned space missions warrants an in-depth understanding how prolonged microgravity affects the human brain. Functional magnetic resonance imaging (fMRI) can pinpoint changes reflecting adaptive neuroplasticity across time. We acquired resting-state fMRI data cosmonauts before, shortly after, and eight months after spaceflight as a follow-up to assess global connectivity over Our results show persisting decreases in posterior cingulate cortex thalamus increases...
Biochemical recurrence occurs approximately in 25-50% of patients with prostate cancer after treatment. However, the prognosis and course disease vary substantially depend on wide range factors. may be caused either by local or metastatic dissemination. Approaches to diagnostics treatment biochemical underwent radical changes over last years due implementation new diagnostic methods clinical practice. The article represents literature review current possibilities detection spread recurrence.
The aim of the work – to present a case radiation-induced complication after radiosurgical stereotaxic treatment cavernous malformation brain. A patient, 34-year-old, applied Radiosurgery Center N. V. Sklifosovsky Research Institute for Emergency Medicine with complaints frequent headaches, general weakness. magnetic resonance imaging brain revealed deep in left hemisphere In order reduce risk re-rupture malformation, it is recommended perform operation using Elekta Leksell Gamma Knife...
INTRODUCTION: In modern clinical practice, the diagnosis establishment and monitoring of pulmonary arteries are important components care for patients with cardiovascular respiratory diseases. However, in Russia, there remains a limited amount epidemiological data on prevalence artery dilation, especially at population level. This study aims to fill this gap by providing population-based dilation city Moscow. With help advanced artificial intelligence technologies, work seeks offer...
This article provides a short overview about existing imaging techniques in the diagnosis of acute pulmonary embolism. Was analyzed scientific papers by domestic and foreign authors. A review diagnostic algorithm, features current difficulties for risk stratification patients with suspected embolism was conducted. The main aspects thromboembolism parameters assessing severity are noted. contribution relatively new perfusion methods, such as dual-energy computed tomography angiopulmonography,...
BACKGROUND . Validation of the SCORE2 scale in Russian population showed high accuracy assessing cardiovascular risk (CVR) men, but not women. The development new methods for CVR women is therefore an urgent task. A number mammographic parameters, such as breast calcification (BC) and density (BD) can be additional biomarkers diseases AIM To assess relationship between results a retrospective analysis mammograms aged 65 years older. MATERIALS AND METHODS Retrospective involved 570 patients...