A5039053886- COVID-19 Clinical Research Studies
- Inflammasome and immune disorders
- Long-Term Effects of COVID-19
- Vitamin C and Antioxidants Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Nutrition, Genetics, and Disease
- Diabetes and associated disorders
- Curcumin's Biomedical Applications
- Vaccine Coverage and Hesitancy
- Diabetes Management and Research
- Pharmacological Receptor Mechanisms and Effects
- SARS-CoV-2 and COVID-19 Research
Moscow State University
2022-2024
Lomonosov Moscow State University
2020-2023
Actuality The course of the novel coronavirus disease (COVID-19) is unpredictable. It manifests in some cases as increasing inflammation to even onset a cytokine storm and irreversible progression acute respiratory syndrome, which associated with risk death patients. Thus, proactive anti-inflammatory therapy remains an open serious question patients COVID-19 pneumonia, who still have signs on days 7-9 disease: elevated C-reactive protein (CRP)>60 mg/dL at least two four clinical signs:...
Introduction The aim of this study was to assess the efficacy and safety a combination bromhexine at dose 8 mg 4 times day spironolactone 50 per in patients with mild moderate COVID 19. Material methods It an open, prospective comparative non-randomized study. 103 were included (33 group 70 control group). All had confirmed 2019 novel coronavirus infection (COVID 19) based on positive polymerase chain reaction (PCR) for SARS-CoV-2 virus RNA and/or typical pattern viral pneumonia multispiral...
The article is devoted to the treatment of new coronavirus infection (COVID-19) in advanced stages disease. types response immune system viral load SARS-CoV-2 with start inflammation process are considered. situation analyzed detail which growing autoimmune (up development a "cytokine storm") affects not only pulmonary parenchyma, but also endothelium small vessels lungs. Simultaneous damage alveoli and microthrombosis accompanied by progressive impairment gas exchange, acute respiratory...
The article focuses on effective treatment of the novel coronavirus infection (COVID-19) at early stages and substantiates requirement for antiviral therapy decreasing viral load to prevent progression. absence a specific SARS-CoV-2 virus is stated. authors analyzed results randomized studies using lopinavir/ritonavir, remdesivir, favipiravir in COVID-19 their potential infection. Among drugs blocking entry into cells, greatest attention was paid antimalaria drugs, chloroquine...
Stress hyperglycemia is a physiological defense mechanism that manifests itself in an increase glycemia acute distress. Despite the fact presence of this phenomenon and its adverse effects on body are not doubt, there still no algorithms for intraoperative management patients without history diabetes mellitus: mandatory control glycemia, frequency control, intervention points glucose, optimal insulin therapy regimen, methods leveling glucose levels. This review discusses definitions stress...
Aim. To assess the tolerability of vaccination with first component Gam-COVID-Vac (Sputnik V), frequency and nature adverse events following immunization (AEFI) depending on gender, age, obesity, chronic diseases. Material Methods. The study included male female patients who received Gam-COVIDVac vaccine at MSU Medical Center. Subsequently, after 14 days, a remote survey respondents was conducted to collect data regarding development requiring use drug treatment or medical care. Results. 732...
The aim of the study was to establish relationship between factors metabolic‑associated diseases and markers premature aging biological age in patients different groups.
 Materials methods. included 151 with metabolic disorders but without clinical signs cardiovascular disease, who were hospitalized or obtained outpatient treatment L. T. Mala National Therapy Institute NAMS Ukraine during period 2019 2021 years. average surveyed 51.4 ± 12.1 years, women accounted for 62.3 % (n = 94)....
Aim To evaluate clinical efficacy of the proactive anti-inflammatory therapy in patients hospitalized for COVID-19 with pneumonia and a risk “cytokine storm”. Material methods The COLORIT study was comparative randomization into 4 groups: colchicine (n=21) 1 mg first 3 days followed by 0.5 mg/day through day 12 or discharge from hospital; secukinumab 300 mg/day, s.c., as single dose (n=20); ruxolitinib 5 mg, twice (n=10); control group no (n=22). effect evaluated after 12±2 inpatient...