Males of a Drosophila melanogaster isogenic line with mutation the major gene for radius incompletus (ri) were treated by standard light heat shock (37 degrees C 90 min) and heavy (transfer males from 37 2 hr to 4 1 back; this procedure was repeated three times). In F1 generation mated nontreated females same line, mass transpositions copia-like mobile genetic element Dm-412 found. The altered positions seem nonrandom; five "hot spots" transposition Probabilities estimated after in control...

The present study was designed to test whether common polymorphism G-50T within the promoter of human CYP2J2 gene is associated with increased risk essential hypertension in a Russian population. We studied 576 unrelated subjects, including 295 patients and 281 healthy subjects. Genotyping for performed by polymerase chain reaction restriction fragment length techniques. frequency -50T variant allele significantly higher versus controls (OR 4.03 95%CI 1.80-9.04 p=0.0004). association -50GT...

Background. The aim was to establish the features of hemodynamic and metabolic parameters in obese patients with true pseudo-resistant arterial hypertension (AH). Material methods. study included 200 uncontrolled AH obesity. Patients were initially prescribed dual antihypertensive therapy. Those who did not reach target blood pressure (BP) levels after 3 months on therapy additionally a third drug. Of 98 assigned triple therapy, 48 BP (27 had 21 resistant AH). These fourth drug...

Materials and methods. As part of the longitudinal study, 29 civilians were examined; all them remained in their place residence during war, not directly combat areas did receive physical damage. Body composition was determined by method bioelectrical impedance using Composition Monitor BF511, Omron, including body fat percentage (FAT, %), skeletal muscle (MUS, visceral level (VIS, %). Hematological biochemical investigations conducted according to standard The enzyme immunoassay with...

Background: The aim of this study was to establish the relationship between metabolic disorders, overweight and obesity with markers accelerated ageing in patients hypertension. Materials methods: One hundred sixteen (the age 35–65 years, women 62.3%) stage 1–2 grade hypertension low/moderate cardiovascular risk (CVR) were included study. 34 (27.59%) obese, 50 (43.1%) overweight, 32 (29.31%) had normal weight. Anthropometric, clinical, biochemical molecular genetic methods (relative telomere...

Abstract Heterozygous familial hypercholesterolemia is associated with a high risk of early ischemic heart disease onset and cardiovascular death. There almost no data about the prevalence in Ukrainian population. The aim study was to assess incidence among patients who were treated “L.T. Malaya Therapy National Institute Academy Medical Sciences Ukraine” due disease. records 600 during 2015-2017 analyzed. Early diagnosed 89 patients. verification has been conducted either on basis...

Patients with NAFLD (non-alcoholic fatty liver disease) and subclinical hypothyroidism are at risk of cardiovascular complications that cause cardiometabolic changes, thus enabling to broaden our understanding the events in a comorbid patient.
 The aim: study hormonal metabolic indicators factors women from combined SH (subclinical hypothyroidism) depending on age.
 Materials methods: 128 patients were studied, which divided into 2 groups: І group – level thyroid-stimulating...

Objective — to evaluate two distinct methods for determining biological age (BA) and aging rates among patients with arterial hypertension (AH) in combination subclinical hypothyroidism (SH) that can be applicable practical medical settings. Materials methods. The study involved 150 (women 54.7%, n=82) an average of 47.1 [39.7;54.0] years, who were divided into three groups reciprocal by sex: the main group included 70 AH combined SH, comparison consisted 50 subjects isolated AH, control 30...

Objective — to evaluate clinical and biochemical parameters related differences in the rate of aging patients with arterial hypertension (AH) during year 2023. Materials methods. Examinations involved 39 AH a median age 51.4 [46.9; 63.2] years, from them 27 were men (69.2%). performed twice: at baseline after treatment preventive activities. Depending on time follow‑up visit, divided into two groups, comparable by gender: group 1 follow up visit conducted weeks first evaluation (n=19), 2...

Objective — to assess the prevalence of major cardiometabolic diseases by identifying their risk factors and comparing them with metabolic disorders stress indicators in military personnel. Materials methods. The study included 74 male personnel an average age 43.4 [31.4; 50.6] years. Among all participants, proportion individuals hypertension (HTN) was 51.4%, dyslipidemia (DLP) 75.7%, metabolic­associated steatotic liver disease (MASLD) 48.6%, overweight or obesity 51.4%. participants were...

The article summarises the data of currently available scientific studies that define known mechanisms DNA methylation and their role in epigenetic regulation human body, health susceptibility to chronic non‑communicable diseases, cellular homeostasis normal function, nucleotide, protein lipid metabolism, neurotransmitter synthesis, redox state, gene expression, inheritance, differentiation, maintenance genome stability genomic imprinting. It describes which nutrients supplements have a...

A simple method of assessment electrocardiogram (ECG) quality based on lossless data compression is proposed. It intended for a quick preliminary ECG in terms further analysis heart rate variability (HRV) sequence R-peaks. The does not require priori information about the type, nature and intensity noise. only output parameter pre-processing step ratio. Thresholds ratio are determined, above which results HRV same as corresponding distorted by For sampling frequency 250 Hz, threshold equal...

In this article the problems of prevalence esophageal cancer and spatial distribution mortality rates from disease are considered using as examples NUTS 2 regions in six countries Central Eastern Europe (Austria, Germany, Czech Republic, Poland, Slovakia Hungary). The analyzed by statistical methods econometrics. A study is carried out features cancer. It allows us to determine more less epidemiologically affected carry detailed studies on link between various factors, such environmental...

Introduction: SIRT1 has attracted great interest due to its role as a regulator of longevity, and therapeutic potential for the prevention treatment aging age-related comorbidities. However, mechanisms by which influences course remain unknown. Methods: The study population included 88 apparently healthy subjects aged 31 – 65 without established atherosclerotic cardiovascular disease or metabolic-associated diseases. Clinical, anthropometric, biochemical parameters were determined in all...