A5056854844- Eicosanoids and Hypertension Pharmacology
- Asthma and respiratory diseases
- Glutathione Transferases and Polymorphisms
- Lipoproteins and Cardiovascular Health
- Human Health and Disease
- Sulfur Compounds in Biology
- Diet, Metabolism, and Disease
- Nutrition, Genetics, and Disease
- Genetic Associations and Epidemiology
- Hormonal Regulation and Hypertension
- Helicobacter pylori-related gastroenterology studies
- Folate and B Vitamins Research
- Cancer, Lipids, and Metabolism
- Vitamin D Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Pharmacogenetics and Drug Metabolism
- IL-33, ST2, and ILC Pathways
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peripheral Artery Disease Management
- Liver Disease Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiovascular Disease and Adiposity
- Psoriasis: Treatment and Pathogenesis
- Pancreatitis Pathology and Treatment
- Cholesterol and Lipid Metabolism
Kursk State Medical University
2016-2025
Ministry of Health of the Russian Federation
2024
Belgorod National Research University
2016
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2013
The present study was designed to investigate whether genetic polymorphisms of the aryl hydrocarbon receptor (AHR) signaling pathway are involved in molecular basis essential hypertension (EH).A total 2160 unrelated Russian individuals comprising 1341 EH patients and 819 healthy controls were recruited into study. Seven common AHR single-nucleotide (SNPs) such as rs2066853, rs2292596, rs2228099, rs1048943, rs762551, rs1056836, rs1800566 genotyped by TaqMan-based allele discrimination...
Enzymes CYP4A11 and CYP4F2 are involved in biosynthesis of vasoactive 20-hydroxyeicosatetraenoic acid may contribute to pathogenesis coronary artery disease (CAD). We investigated whether polymorphisms the genes associated with risk CAD Russian population. DNA samples from 1323 unrelated subjects (637 angiographically confirmed patients 686 age- sex-matched healthy individuals) were genotyped for rs3890011, rs9332978, rs9333029 rs3093098 rs1558139 by using Mass-ARRAY 4 system. SNPs rs3890011...
Abstract The present study investigated a joint contribution of matrix metalloproteinases (MMPs) genes to ischemic stroke (IS) development and analyzed interactions between MMP genome‐wide associated loci for IS. A total 1288 unrelated Russians (600 IS patients 688 healthy individuals) from Central Russia were recruited the study. Genotyping seven single nucleotide polymorphisms (SNPs) (rs1799750, rs243865, rs3025058, rs11225395, rs17576, rs486055, rs2276109) eight done using Taq‐Man–based...
The purpose of this pilot study was to explore whether polymorphisms in genes encoding the catalytic (GCLC) and modifier (GCLM) subunits glutamate-cysteine ligase, a rate-limiting enzyme glutathione synthesis, play role development ischemic stroke (IS) extent brain damage. A total 1288 unrelated Russians, including 600 IS patients 688 age- sex-matched healthy subjects, were enrolled for study. Nine common single nucleotide (SNPs) GCLC GCLM genotyped using MassArray-4 system. SNP rs2301022...
The present pilot study aimed to investigate whether common single nucleotide polymorphisms (SNPs) in the gene encoding glutathione S-transferase omega 1 (GSTO1), both individually and combination with variants of catalytic subunit glutamate cysteine ligase (GCLC) environmental risk factors, are associated psoriasis. research included a total 944 participants, comprising 474 individuals diagnosed psoriasis 470 healthy control subjects. Five SNPs GSTO1 gene—specifically, rs11191736,...
The present study was designed to test whether common polymorphism G-50T within the promoter of human CYP2J2 gene is associated with increased risk essential hypertension in a Russian population. We studied 576 unrelated subjects, including 295 patients and 281 healthy subjects. Genotyping for performed by polymerase chain reaction restriction fragment length techniques. frequency -50T variant allele significantly higher versus controls (OR 4.03 95%CI 1.80-9.04 p=0.0004). association -50GT...
Gene encoding flavin-containing monooxygenase 3 (FMO3), a microsomal antioxidant defense enzyme, has been suggested to contribute essential hypertension (EH). The present study was designed investigate whether common functional polymorphism E158K (rs2266782) of the FMO3 gene is associated with EH susceptibility in Russian population. A total 2 995 unrelated subjects from Kursk (1 362 patients and 843 healthy controls) Belgorod (357 422 population regions Central Russia were recruited for...
Numerous studies demonstrated an importance of cytochrome P-450 epoxygenase pathway arachidonic acids metabolism for the pathogenesis essential hypertension (EH). The present study was designed to investigate whether common single-nucleotide polymorphisms (SNP) CYP2C gene subfamily such as CYP2C8 (rs7909236 and rs1934953), CYP2C9 (rs9332242), CYP2C19 (rs4244285) are associated with susceptibility EH in Russian population. A total 816 unrelated individuals comprising 425 patients 391...
Inconsistent results of association studies investigated the role glutathione S-transferase genes in idiopathic male infertility may be explained by ethnical differences gene-gene and gene-environment interactions. In this study, we a joint contribution GSTM1, GSTT1 GSTP1 gene polymorphisms cigarette smoking to risk Russian men. DNA samples from 203 infertile 227 fertile men were genotyped multiplex polymerase chain reaction (GSTM1 deletions) PCR-restriction fragment length polymorphism...
Although oxidative stress is a cardinal feature of bronchial asthma, the role interactions between environmental oxidant/antioxidant exposures and antioxidant genes in asthma aetiology has yet to be determined. The present study was conducted investigate whether two common polymorphisms -21A > T -262C catalase (CAT) gene are associated with susceptibility Russian population test hypothesis that risk attributed CAT genotypes could dependent on both oxidant (tobacco smoking) (fruit vegetable...
Background Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify genes that interact with ever smoking in adult onset asthma. Methods We performed a genome-wide interaction analysis six participating GABRIEL consortium following two meta-analyses approaches based on 1) overall effect and 2) subjects exposure. discovery meta-analysis including 4,057 European...
Oxidative stress resulting from an increased amount of reactive oxygen species and imbalance between oxidants antioxidants plays important role in the pathogenesis asthma. The present study tested hypothesis that genetic susceptibility to allergic nonallergic variants asthma is determined by complex interactions genes encoding antioxidant defense enzymes (ADE). We carried out a comprehensive analysis associations adult 46 single nucleotide polymorphisms 34 ADE 12 other candidate Russian...
The study was designed to evaluate putative mechanisms by which lipid-associated loci identified genome-wide association studies (GWAS) are involved in the molecular pathogenesis of coronary artery disease (CAD) using a comprehensive statistical and bioinformatics analysis. A total 1700 unrelated individuals Slavic origin from Central Russia, including 991 CAD patients 709 healthy controls were examined. Sixteen GWAS selected European genotyped MassArray-4 system. polymorphisms associated...
Background: Since oxidative stress plays a role in the pathogenesis of ischemic stroke (IS), it is important to investigate molecular mechanisms contributing redox homeostasis and glutathione metabolism. The aim study: To analyze association rs11546155 polymorphism gamma-glutamyltransferase 7 (GGT7) gene with risk stroke. Materials methods: DNA samples from 600 patients IS 688 controls were used for genotyping SNP by real-time PCR allele discrimination using TaqMan probes. Results: It was...
Objective: The study was designed to assess the effects of polymorphisms in genes associated with essential hypertension on variation erythrocyte membrane proteins (EMPs) hypertensive patients. Methods: Major EMPs content analyzed blood from 1162 unrelated Russians (235 patients, 176 healthy controls, and 751 random individuals Central Russia population). Essential patients were genotyped for 11 susceptibility including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744),...
The aim of this pilot study was to investigate whether single nucleotide polymorphisms (SNP) in the gene encoding catalytic subunit glutamate cysteine ligase (GCLC) are associated with risk and clinical features psoriasis. A total 944 unrelated individuals, including 474 patients a diagnosis psoriasis 470 healthy controls, were recruited for study. Six common SNPs GCLC genotyped using MassArray-4 system. Polymorphisms rs648595 (OR=0.56 95%CI 0.35-0.90, Pperm=0.017) rs2397147 (OR=0.54...