A5069326648- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Allergic Rhinitis and Sensitization
- Indoor Air Quality and Microbial Exposure
- Occupational exposure and asthma
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Noise Effects and Management
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Climate Change and Health Impacts
- Contact Dermatitis and Allergies
- Delphi Technique in Research
- Neonatal Respiratory Health Research
- Air Quality Monitoring and Forecasting
- Food Allergy and Anaphylaxis Research
- Health, Environment, Cognitive Aging
- Respiratory viral infections research
- Nutritional Studies and Diet
- Occupational Health and Safety Research
- Glutathione Transferases and Polymorphisms
- Smoking Behavior and Cessation
- Inhalation and Respiratory Drug Delivery
- Dermatology and Skin Diseases
- School Health and Nursing Education
Centre de recherche en Epidémiologie et Santé des Populations
2013-2025
Université de Versailles Saint-Quentin-en-Yvelines
2016-2025
Hôpital Sainte-Périne
2018-2025
Assistance Publique – Hôpitaux de Paris
2018-2025
Laboratoire d'études sur les monothéismes
2021-2025
Inserm
2015-2024
Université Paris-Saclay
2020-2024
Université Paris-Sud
2011-2024
Hôpital Paul-Brousse
2012-2024
Inserm Transfert
2024
MASK-air
<h3>Rationale:</h3> There is increasing interest regarding asthma heterogeneity in relation to inflammatory patterns. <h3>Objectives:</h3> To assess phenotypic characteristics, particular clinical presentation of the disease, 381 well-characterised adults with from French Epidemiological study on Genetics and Environment Asthma (EGEA) according their blood pattern. <h3>Methods:</h3> Four patterns were defined eosinophil (EOS) neutrophil (NEU) count cut-off points. Samples ⩾250...
Single nucleotide polymorphisms (SNPs) at chromosome 17q21 confer an increased risk of early-onset asthma. The objective was to study whether SNPs modify associations between early respiratory infections and Association analysis conducted in 499 children (268 with asthma, median age 11 yrs) from the Epidemiological Study on Genetics Environment Asthma (EGEA). 12-yr follow-up data were used assess persistent or remittent asthma young adulthood. Respiratory infection before 2 yrs assessed...
We aimed to study the associations between household use of cleaning sprays and asthma symptoms control asthma, in females from Epidemiological Study on Genetics Environment Asthma (EGEA). Data were available for 683 (mean age 44 yrs, 55% never smokers, 439 without 244 with current asthma). Both domestic exposures phenotypes (asthma symptom score, poorly-controlled (56%)) evaluated as previously described European Community Respiratory Health Survey. Associations using logistic nominal...
<h3>Background</h3> The associations between exposure to air pollution and asthma control are not well known. objective of this study was assess the association long-term NO<sub>2</sub>, O<sub>3</sub> PM<sub>10</sub> in follow-up Epidemiological on Genetics Environment Asthma (EGEA2) (2003–2007). <h3>Methods</h3> Modelled outdoor estimates were linked each residential address using 4 km grid pollutant surface developed by French Institute 2004. assessed 481 subjects with current a...
Abstract Background Children with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remains poorly studied in adolescents adults using defined molecules. We investigated sensitization patterns towards a broad panel of aeroallergen components focus on individuals multimorbidity. Methods reactivity 64 micro‐arrayed molecules was determined the Me DALL ‐chip samples from French EGEA study (n = 840, age 40.7 ± 17.1) Swedish population‐based...
To what extent blood granulocyte patterns may predict asthma control remains under-studied. Our aim was to study associations between neutrophilia and eosinophilia outcomes in adults. Analyses were conducted 474 asthmatics from the first follow-up of Epidemiological Study on Genetics Environment Asthma (EGEA2), including 242 who adults a decade earlier (EGEA1). At EGEA2, assessed using Global Initiative for definition (2015), exacerbations by use urgent care or courses oral corticosteroids...
Validated questionnaires are used to assess asthma control over the past 1-4 weeks from reporting. However, they do not adequately capture in patients with fluctuating symptoms. Using Mobile Airways Sentinel Network for airway diseases (MASK-air) app, we developed and validated an electronic daily score (e-DASTHMA).We MASK-air data (freely available users 27 countries) develop different scores asthma. Data-driven were based on symptoms reported by a visual analogue scale (VAS) self-reported...
We tested the hypotheses that catalase activity is modified by CAT single nucleotide polymorphisms (SNPs) (-262;-844), and their interactions with oxidant exposures (coal dusts, smoking), lymphotoxin alpha (LTA, NcoI) tumor necrosis factor (TNF, -308) in 196 miners. Erythrocyte catalase, superoxide dismutase, glutathione peroxidase activities were measured. The -262 SNP was related to lower (104, 87 72 k/g hemoglobin for CC, CT TT, respectively, p < 0.0001). Regardless of SNPs, LTA NcoI but...
Summary Background Mono‐ and polysensitization are different IgE‐mediated allergic phenotypes in children. Allergic sensitization is associated with both asthma rhinitis, however, associations between the pattern particularly rhinitis remains poorly studied adults. Aim The aim of this study was to assess how associates asthma, their multimorbidity. Methods 1199 adults from EGEA study, extensive phenotypic characterization all data available on skin prick tests 10 allergens, total IgE blood...