A5012149199- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Climate Change and Health Impacts
- Respiratory and Cough-Related Research
- IL-33, ST2, and ILC Pathways
- Respiratory viral infections research
- Noise Effects and Management
- Pediatric health and respiratory diseases
- Neonatal Respiratory Health Research
- Air Quality Monitoring and Forecasting
- Allergic Rhinitis and Sensitization
- Occupational exposure and asthma
- Energy and Environment Impacts
- Delphi Technique in Research
- Child and Adolescent Health
- Urban Green Space and Health
- Epigenetics and DNA Methylation
- Respiratory Support and Mechanisms
- Hemoglobinopathies and Related Disorders
- Statistical Methods in Epidemiology
- Tracheal and airway disorders
- Genetic Associations and Epidemiology
- Thermoregulation and physiological responses
- Muscle metabolism and nutrition
Centre Hospitalier Universitaire de Grenoble
2011-2024
Université Grenoble Alpes
2015-2024
Centre National de la Recherche Scientifique
2017-2024
Institut de Biosciences et Biotechnologies
2023-2024
Institut pour l'avancée des biosciences
2014-2024
Inserm
2015-2024
Hôpital Nord
2023
Keio University
2023
Université Joseph Fourier
2009-2014
Centre de recherche en Epidémiologie et Santé des Populations
2011
There is a need to improve asthma characterisation by integrating multiple aspects of the disease. The aim present study was identify distinct phenotypes applying latent class analysis (LCA), model-based clustering method, two large epidemiological studies. Adults with who participated in follow-up Epidemiological Study on Genetics and Environment Asthma (EGEA2) (n = 641) European Community Respiratory Health Survey (ECRHSII) 1,895) were included. 19 variables covering personal...
The temporal stability of adult asthma phenotypes identified using clustering methods has never been addressed. Longitudinal cluster-based may provide novel insights in the study natural history asthma.To compare phenotype structures a decade apart adults and to address individuals' phenotypic transition across these phenotypes.The latent analysis was applied on longitudinal data (twice, 10 yr apart) from 3,320 with who took part European Community Respiratory Health Survey, Swiss Cohort...
Background: Health‐related quality‐of‐life (HRQL) has been poorly studied in large samples of asthmatics from the general population. HRQL and its relationship to asthma‐severity were assessed among 900 enrolled European Community Respiratory Health Survey. Methods: Among asthmatics, 864 completed short form‐36 (SF‐36) questionnaire 477 also Asthma Quality‐of‐life Questionnaire (AQLQ). A 4‐class scale, combining clinical items, forced expiratory volume 1 s level treatment different...
Abstract Background Children with multimorbid asthma and rhinitis show IgE polysensitization to several allergen sources. This association remains poorly studied in adolescents adults using defined molecules. We investigated sensitization patterns towards a broad panel of aeroallergen components focus on individuals multimorbidity. Methods reactivity 64 micro‐arrayed molecules was determined the Me DALL ‐chip samples from French EGEA study (n = 840, age 40.7 ± 17.1) Swedish population‐based...
To what extent blood granulocyte patterns may predict asthma control remains under-studied. Our aim was to study associations between neutrophilia and eosinophilia outcomes in adults. Analyses were conducted 474 asthmatics from the first follow-up of Epidemiological Study on Genetics Environment Asthma (EGEA2), including 242 who adults a decade earlier (EGEA1). At EGEA2, assessed using Global Initiative for definition (2015), exacerbations by use urgent care or courses oral corticosteroids...
The aim of the study was to identify genetic variants associated with refined asthma phenotypes enabling multiple features disease be taken into account. Latent class analysis (LCA) applied in 3001 adults ever having recruited frame three epidemiological surveys (the European Community Respiratory Health Survey (ECRHS), Swiss Study on Air Pollution and Lung Disease Adults (SAPALDIA) Epidemiological Genetics Environment Asthma (EGEA)). 14 personal phenotypic characteristics, gathered from...
Background: Fine particulate matter (PM2.5) has been found to be detrimental respiratory health of children, but few studies have examined the effects prenatal PM2.5 oxidative potential (OP) on lung function in infants and preschool children. Objectives: We estimated associations personal exposure OP during pregnancy offspring objective parameters compared strengths between both metrics. Methods: used data from 356 mother–child pairs SEPAGES cohort. PM filters collected twice a week were...
Errors in address geocodes may affect estimates of the effects air pollution on health.We investigated impact four geocoding techniques association between urban estimated with a fine-scale (10 m × 10 m) dispersion model and lung function adults.We measured forced expiratory volume 1 sec (FEV1) vital capacity (FVC) 354 adult residents Grenoble, France, who were participants two well-characterized studies, Epidemiological Study Genetics Environment Asthma (EGEA) European Community Respiratory...
The few studies that have examined associations between greenspace and lung function in adulthood yielded conflicting results none whether the rate of decline is affected.We explored association residential change over 20 years 5559 adults from 22 centers 11 countries participating population-based, international European Community Respiratory Health Survey.Forced expiratory volume 1 s (FEV1) forced vital capacity (FVC) were measured by spirometry when participants approximately 35...
While the adverse effects of short-term ambient ozone exposure on lung function are well-documented, impact long-term remains poorly understood, especially in adults.We aimed to investigate association between and decline. The 3014 participants were drawn from 17 centers across eight countries, all which European Community Respiratory Health Survey (ECRHS). Spirometry was conducted measure pre-bronchodilation forced expiratory volume 1 s (FEV1) vital capacity (FVC) at approximately 35, 44,...
Exposure to phthalates and synthetic phenols is ubiquitous. Some of them are suspected impact child respiratory health, although evidence still remains insufficient. This study investigated the associations between prenatal exposure phenols, individually as a mixture, health assessed by objective lung function measures since 2 months age. Among 479 mother-child pairs from SEPAGES cohort, 12 13 phthalate non-phthalate plasticizer metabolites were measured in pools including each 21 urine...
Poly- and perfluoroalkyl substances (PFAS) are used in a wide range of products. Experimental studies suggested impaired lung development pro-inflammatory response following exposure to some PFAS. We aimed assess the associations between prenatal PFAS children respiratory health.The study is based on 433 mother-child pairs. 26 were measured maternal serum collected during pregnancy. Lung function parameters at 2 months using tidal breathing flow-volume loops multiple-breath nitrogen washout...
Research based on cluster analyses led to the identification of particular phenotypes confirming phenotypic heterogeneity asthma. The long-term clinical course asthma defined by clustering analysis remains unknown, although it is a key aspect underpin their relevance. We aimed estimate risk poor events between clusters identified 20 years earlier.The study relied two cohorts adults with 20-year follow-up, ECRHS (European Community Respiratory Health Survey) and EGEA (Epidemiological Genetics...
Asthma is a chronic respiratory disease without cure, although there exists spontaneous remission. Genome-wide association (GWA) studies have pinpointed genes associated with asthma development, but did not investigate remission.We performed GWA study to develop insights in remission.Clinical remission (ClinR) was defined by the absence of treatment and wheezing last year attacks 3 years complete (ComR) similarly additionally normal lung function bronchial hyperresponsiveness (BHR). A on...
Longitudinal studies assessing the association of profiles allergen-specific IgE (sIgE) sensitization to a large range allergen molecules and respiratory health are rare. We aimed assess trajectories molecular sIgE from childhood adulthood their associations with health.IgE reactivity microarrayed were measured in (EGEA1) 12 years later adult life (EGEA2) among 291 EGEA participants (152 asthma). At each time point, identified by latent class analysis (LCA) considering IgE-reactivity 38 most...