A5068594957- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Neonatal Respiratory Health Research
- Thermal Regulation in Medicine
- Atomic and Subatomic Physics Research
- Asthma and respiratory diseases
- Effects and risks of endocrine disrupting chemicals
- Cardiac Arrest and Resuscitation
- Advanced MRI Techniques and Applications
- Air Quality and Health Impacts
- Medical Imaging Techniques and Applications
- Advanced X-ray Imaging Techniques
- Nuclear Physics and Applications
- Quantum, superfluid, helium dynamics
- Health, Environment, Cognitive Aging
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Non-Invasive Vital Sign Monitoring
- Pleural and Pulmonary Diseases
- Heart Rate Variability and Autonomic Control
- Obstructive Sleep Apnea Research
- Climate Change and Health Impacts
- Hemodynamic Monitoring and Therapy
- Airway Management and Intubation Techniques
Centre Hospitalier Universitaire de Grenoble
2016-2025
Inserm
2015-2025
Université Grenoble Alpes
1998-2025
European Synchrotron Radiation Facility
2007-2024
Synchrotron Radiation for Biomedicine
2014-2024
Karlsruhe Institute of Technology
2024
Karlsruhe University of Applied Sciences
2024
Grenoble Institute of Neurosciences
2020-2021
Centre Inria de l'Université Grenoble Alpes
2020
University Hospital of Geneva
2017-2019
des établissements d'enseignement et de recherche français ou étrangers, laboratoires publics privés.
The aim of this study was to assess the feasibility a novel respiration-gated spiral synchrotron radiation computed tomography (SRCT) technique for direct quantification absolute regional lung volumes, using stable xenon (Xe) gas as an inhaled indicator. Spiral SRCT with K-edge subtraction two monochromatic x-ray beams used visualize and directly quantify Xe concentrations airspace volumes in three-dimensional (3D) reconstructed images. Volume measurements were validated hollow Xe-filled...
Rationale: Methacholine (Mch) is routinely used to assess bronchial hyperreactivity; however, little known about the differences in lung response pattern between this provocation and that observed with ovalbumin (Ova) after allergic sensitization.Objectives: To compare (1) central versus peripheral effects of Mch Ova within by combining measurements airway tissue mechanics synchrotron radiation (SR) imaging, (2) extent which mechanical imaging parameters are correlated.Methods: We...
In humans, studies based on Developmental Origins of Health and Disease (DOHaD) concept targeting short half-lived chemicals, including many endocrine disruptors, generally assessed exposures from spot biospecimens. Effects early-life exposure to atmospheric pollutants were reported, outdoor air pollution levels. For both families, misclassification is expected these designs: for non-persistent because a biospecimen unlikely capture over windows longer than few days; pollutants, indoor...
Airway closure is involved in adverse effects of mechanical ventilation under both general anesthesia and acute respiratory distress syndrome patients. However, direct evidence characterization individual airway lacking. Here, we studied the same peripheral airways intact lungs anesthetized mechanically ventilated rabbits, at baseline following lung injury, using high-resolution synchrotron phase-contrast CT.Laboratory animal investigation.European radiation facility.Six New-Zealand White...
Background: Fine particulate matter (PM2.5) has been found to be detrimental respiratory health of children, but few studies have examined the effects prenatal PM2.5 oxidative potential (OP) on lung function in infants and preschool children. Objectives: We estimated associations personal exposure OP during pregnancy offspring objective parameters compared strengths between both metrics. Methods: used data from 356 mother–child pairs SEPAGES cohort. PM filters collected twice a week were...
Most previous studies investigating the associations between prenatal exposure to phthalates and fetal growth relied on measurements of phthalate metabolites at a single time point. They also focused weight birth without assessing over pregnancy, preventing identification potential periods vulnerability. We examined pregnancy urinary outcomes measured twice during birth.
Endocrine disrupting compounds (EDCs) such as phthalates and phenols can affect placental functioning fetal health, potentially via epigenetic modifications. We investigated the associations between pregnancy exposure to synthetic estimated from repeated urine sampling genome wide DNA methylation.
Some synthetic phenols alter hormonal pathways involved in successful pregnancy and fetal development. Despite high within-subject temporal variability of phenols, previous studies mostly utilized spot urine samples to assess exposure. Herein we investigated associations between exposure eight assessed multiple pooled steroid hormones maternal hair reflecting cumulative hormone levels over the weeks months.
3D virtual histology of formalin-fixed and paraffin-embedded (FFPE) tissue by means phase contrast micro-computed tomography (micro-CT) is an increasingly popular technique, as it allows the architecture to be addressed without need additional heavy ion based staining approaches. Therefore, can applied on archived standard FFPE blocks. However, one major concerns using micro-CT in combination with blocks trapped air within tissue. While inclusion block does not strongly impact workflow...
Small airways play a key role in the distribution of ventilation and matching to perfusion. The purpose this study was introduce an imaging method that allows measurement regional lung evaluation function with small diameter.
BackgroundAlthough a high inspired oxygen fraction (FiO2) is commonly used in paediatric anaesthesia, the impact on postoperative lung function unclear. We compared volume, ventilation heterogeneity, and respiratory mechanics anaesthetised children randomised to receive low or FiO2 intraoperatively.MethodsIn double-blind controlled trial, scheduled for elective surgery were randomly assigned 100% (n=29) 80% during anaesthesia induction emergence. During maintenance of participants FiO2=100%...
Studies focusing on the neurodevelopmental effects of phthalates seldom consider exposure during infancy, a critical period for brain development. Most rely parent-completed questionnaires to assess child neurodevelopment, which may be subject reporting error. We studied associations between prenatal and infancy objective measures neurodevelopment at age two. relied 151 mother-child pairs from SEPAGES cohort. Women were asked collect three spot urine samples per day over seven consecutive...
Abstract To understand the determinants of inhaled aerosol particle distribution and targeting in lung, knowledge regional deposition, lung morphology ventilation, is crucial. No single imaging modality allows acquisition all such data together. Here we assessed feasibility dual-energy synchrotron radiation to this end anesthetized rabbits; both normal (n = 6) following methacholine (MCH)-induced bronchoconstriction 6), a model asthma. We used K-edge subtraction CT (KES) quantitatively map...
Positive pressure ventilation exposes the lung to mechanical stresses that can exacerbate injury. The exact mechanism of this pathologic process remains elusive. goal study was describe recruitment/derecruitment at acinar length scales over short-time frames and test hypothesis interdependence between neighboring units determines spatial temporal distributions recruitment/derecruitment, using a computational model.Experimental animal study.International synchrotron radiation laboratory.Four...
Abstract In this article, we present an X-ray tomographic imaging method that is well suited for pulmonary disease studies in animal models to resolve the full pathway from gas intake exchange. Current state-of-the-art synchrotron-based phase-contrast methods allow three-dimensional microscopic data be acquired non-destructively scan times of order seconds with good soft tissue contrast. However, when studying multi-scale hierarchically structured objects, such as mammalian lung, overall...
Recent trends in hard X-ray micro-computed tomography (microCT) aim at increasing both spatial and temporal resolutions. These challenges require intense photon beams. Filtered synchrotron radiation beams, also referred to as `pink beams', which are emitted by wigglers or bending magnets, meet this need, owing their broad energy range. In work, the new microCT station installed biomedical beamline ID17 of European Synchrotron is described an overview preliminary results obtained for...
Importance Little is known about long-term associations of early-life exposure to extreme temperatures with child health and lung function. Objectives To investigate the association prenatal postnatal heat or cold newborn function identify windows susceptibility. Design, Setting, Participants This population-based cohort study (SEPAGES) recruited pregnant women in France between July 8, 2014, 24, 2017. Data on temperature exposure, function, covariates were available from 343 mother-child...
Abstract STUDY QUESTION Is exposure to environmental chemicals associated with modifications of placental morphology and function? SUMMARY ANSWER Phthalates, a class ubiquitous chemicals, showed an association altered weight, vascular resistance (PVR), efficiency. WHAT IS KNOWN ALREADY Only few epidemiological studies have assessed the effects phenols phthalates on health. Their results were affected by measurement errors linked rapid excretion these compounds reliance limited number spot...