A5074483178- Advanced X-ray Imaging Techniques
- Advanced X-ray and CT Imaging
- Medical Imaging Techniques and Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced Electron Microscopy Techniques and Applications
- Nuclear Physics and Applications
- Graphene research and applications
- Non-Destructive Testing Techniques
- Advanced MRI Techniques and Applications
- Surface Chemistry and Catalysis
- Advanced Neuroimaging Techniques and Applications
- Molecular Junctions and Nanostructures
- Colorectal Cancer Surgical Treatments
- MRI in cancer diagnosis
- Heat shock proteins research
- Welding Techniques and Residual Stresses
- Boron and Carbon Nanomaterials Research
- Tissue Engineering and Regenerative Medicine
- Ultrasonics and Acoustic Wave Propagation
- Radiomics and Machine Learning in Medical Imaging
- Advanced Fluorescence Microscopy Techniques
- Cultural Heritage Materials Analysis
- Inorganic Chemistry and Materials
- Amyotrophic Lateral Sclerosis Research
- Lymphatic System and Diseases
Istituto di Nanotecnologia
2016-2025
University College London
2019-2024
National Research Council
2017-2021
Istituto Nanoscienze
2017-2020
University of Rome Tor Vergata
2019
Sapienza University of Rome
2014-2018
University of Brescia
2015
When considering the acquisition of experimental synchrotron radiation (SR) X-ray CT data, reconstruction workflow cannot be limited to essential computational steps flat fielding and filtered back projection (FBP). More refined image processing is often required, usually compensate artifacts enhance quality reconstructed images. In principle, it would desirable optimize at facility during experiment (beamtime). However, several practical factors affect part users are likely conclude...
Abstract The degenerative effects of multiple sclerosis at the level vascular and neuronal networks in central nervous system are currently object intensive investigation. Preclinical studies have demonstrated efficacy mesenchymal stem cell (MSC) therapy experimental autoimmune encephalomyelitis (EAE), animal model for sclerosis, but neuropathology specific lesions EAE MSC treatment under debate. Because conventional imaging techniques entail protocols that alter tissues, limiting...
Scanning tunneling microscopy and X-ray spectroscopy measurements are combined to first-principles simulations investigate the formation of graphene nanoribbons (GNRs) on Au(110), as based surface-mediated reaction 10,10′-dibromo-9,9′-bianthracene (DBBA) molecules. At variance with Au(111), two different pathways identified for GNR self-assembly controlled by both adsorption temperature surface coverage DBBA molecular precursors. Room-temperature deposition Au(110) leads same steps obtained...
Alzheimer’s disease (AD), a debilitating neurodegenerative disorder, remains one of the foremost public health challenges affecting more than 30 million people worldwide with etiology still largely enigmatic. The intricate gut-brain axis, serving as vital communication network between gut and brain, appears to wield influence in progression AD. Our study showcases remarkable precision x-ray phase-contrast tomography (XPCT) conducting an advanced three-dimensional examination cellular...
Iron-phthalocyanine and cobalt-phthalocyanine chains, assembled along the Au(110)-(1×2) reconstructed channels, present a strong interaction with Au metallic states, via central metal ion. X-ray photoemission spectroscopy from metal-2p core-levels valence band high-resolution ultraviolet photoelectron bring to light signatures of metal-phthalocyanine single-layer gold. The charge transfer molecule causes emerging core level component at lower binding energy respect that measured in molecular...
Abstract A collection of more than 1800 carbonized papyri, discovered in the Roman ‘Villa dei Papiri’ at Herculaneum is unique classical library survived from antiquity. These papyri were charred during 79 A.D. Vesuvius eruption, a circumstance which providentially preserved them until now. This magnificent contains an impressive amount treatises by Greek philosophers and, especially, Philodemus Gadara, Epicurean thinker 1st century BC. We read many portions text hidden inside using enhanced...
Abstract Margins of wide local excisions in breast conserving surgery are tested through histology, which can delay results by days and lead to second operations. Detection margin involvement intraoperatively would allow the removal additional tissue during same intervention. X-ray phase contrast imaging (XPCI) provides soft sensitivity superior conventional X-rays: we propose its use detect intraoperatively. We have developed a system that perform phase-based computed tomography (CT) scans...
Abstract A significant number of patients receiving breast-conserving surgery (BCS) for invasive carcinoma and ductal in situ (DCIS) may need reoperation following tumor-positive margins from final histopathology tests. All current intraoperative margin assessment modalities have specific limitations. As a first step towards the development compact system specimen imaging based on edge illumination x-ray phase contrast, we prove that system’s dimensions can be reduced without affecting...
Recent trends in hard X-ray micro-computed tomography (microCT) aim at increasing both spatial and temporal resolutions. These challenges require intense photon beams. Filtered synchrotron radiation beams, also referred to as `pink beams', which are emitted by wigglers or bending magnets, meet this need, owing their broad energy range. In work, the new microCT station installed biomedical beamline ID17 of European Synchrotron is described an overview preliminary results obtained for...
The assessment of margin involvement is a fundamental task in breast conserving surgery to prevent recurrences and reoperations. It usually performed through histology, which makes the process time consuming can complete volumetric analysis large specimens. X-ray phase contrast tomography combines high resolution, sufficient penetration depth soft tissue contrast, therefore provide potential solution this problem. In work, we used high-resolution implementation edge illumination based on...
Abstract Visualization and characterization of $$\beta$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>β</mml:mi></mml:math> -amyloid deposits is a fundamental task in pre-clinical study Alzheimer’s disease (AD) to assess its evolution monitor the efficiency new therapeutic strategies. While cerebellum one brain areas most underestimated context AD, renewed interest cerebellar lesions has recently arisen as they may link motor cognitive alterations. Thus, we quantitatively...
Graphene grown on crystalline metal surfaces is a good candidate to act as buffer layer between the and organic molecules that are deposited top, because it offers possibility control interaction substrate molecules. High-resolution angular-resolved ultraviolet photo electron spectroscopy (ARPES) used determine states of iron phthalocyanine adsorbed onto graphene Ni(111). The deposition induces quenching Ni d surface minority band appearance an interface state graphene/Ni(111). results have...
Abstract The 3D complexity of biological tissues and intricate structural-functional connections call for state-of-the-art X-ray imaging approaches to overcome limitations classical imaging. Unlike other techniques, phase-contrast tomography (XPCT) offers a highly sensitive approach investigate different disease-relevant networks at levels ranging from single cell through intact organ. We present here concomitant study the evolution tissue damage inflammation in organs affected by disease...
We report on the development of a low-energy x-ray phase-based microscope using intensity-modulation masks for single-shot retrieval three contrast channels: transmission, refraction, and ultra-small-angle scattering or dark field. The method is based beam tracking, an incoherent imaging approach. demonstrate that spatial resolution this system does not depend focal spot size nor detector pixel pitch, as opposed to conventional propagation-based imaging, it only dependent mask aperture size....
High-temperature (1000 °C) thermolytic decomposition of ethane 1,2-diamineborane (BH3NH2CH2CH2NH2BH3) deposited onto a Cu foil has been performed in an ultra-high-vacuum environment. A combined thermolytic, structural (x-ray diffraction), microscopic (scanning electron microscopy) and spectroscopic (Raman, x-ray photoemission spectroscopy) analysis, identified ternary borocarbonitride (BCN) compound as result the process. The obtained BCN is nanocrystalline, surrounded by crystallites...
Ethane 1,2-diamineborane (EDAB) is an alkyl-containing amine-borane adduct with improved hydrogen desorption properties as compared to ammonia borane. In this work, it reported the high temperature thermolytic decomposition of EDAB. Thermolysis EDAB has been investigated by concomitant thermogravimetry-differential thermal analysis-mass spectrometry experiments. shows up four H2 events below 1000 °C. Small fractions CH4, C2H4 and CO/CO2 are also observed at moderate-high temperatures. The...
X-ray phase contrast imaging is gaining importance as an tool. However, it common for detection techniques to be sensitive the derivatives of phase. Therefore, integration differential images a fundamental step both access quantitative pixel content and further analysis such segmentation. The noisy data leads artefacts with severe impact on image quality its content. In this work, method based Wiener filter presented tested using simulated real obtained edge illumination method. shown...
The design of an X-ray phase contrast tomography system for intra-operative specimen imaging based on edge illumination is presented. use makes possible working with large focus, polychromatic sources reducing acquisition times scans down to values compatible clinical use, while maintaining sensitivity in a compact device. results collected so far show that application this technology breast conservation surgery has great potential reduce re-operations, thus saving additional costs...
We report a qualitative study on central nervous system (CNS) damage that demonstrates the ability of X-ray phase contrast tomography (XPCT) to confirm data obtained with standard 2D methodology and permits description additional features are not detected or other 3D techniques. In magnetic resonance computed tomography, XPCT makes possible high-resolution imaging soft tissues classically considered “invisible” X-rays without use agents, need for intense processing tissue required by Most...
The suppression of ring artifacts in x-ray computed tomography (CT) is a required step practical applications; it can be addressed by introducing refined digital low pass filters within the reconstruction process. However, these may introduce additional ringing when simultaneously imaging pure phase objects and elements having non-negligible absorption coefficient. Ringing originates at sharp interfaces, due to truncation spatial high frequencies, severely affects qualitative quantitative...