A5110736283- Advanced Battery Technologies Research
- Advancements in Battery Materials
- Respiratory Support and Mechanisms
- Advanced Battery Materials and Technologies
- Advanced X-ray Imaging Techniques
- Thermal Regulation in Medicine
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Advanced X-ray and CT Imaging
- Inhalation and Respiratory Drug Delivery
- Pleural and Pulmonary Diseases
- Nuclear Physics and Applications
- Pulmonary Hypertension Research and Treatments
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Medical Imaging Techniques and Applications
- Neonatal Respiratory Health Research
- Radiomics and Machine Learning in Medical Imaging
- Electron and X-Ray Spectroscopy Techniques
- Lung Cancer Diagnosis and Treatment
- Hemodynamic Monitoring and Therapy
- Drilling and Well Engineering
- Quantum, superfluid, helium dynamics
- Semiconductor materials and devices
- Cardiac Arrest and Resuscitation
- Composite Material Mechanics
European Synchrotron Radiation Facility
2014-2025
Elkhorn Slough Foundation
2022-2023
Université Grenoble Alpes
2019-2021
Inserm
2015-2021
European Science Foundation
2021
Grenoble Institute of Neurosciences
2021
Synchrotron Radiation for Biomedicine
2021
Uppsala University
2016-2020
Groupe de Recherches sur l’Analyse Multimodale de la Fonction Cérébrale
2017
Centre Hospitalier Universitaire Amiens-Picardie
2017
The thermal response of Li-ion cells can greatly vary for identical cell designs tested under conditions, the distribution which is costly to fully characterize experimentally. open-source Battery Failure Databank presented here contains robust, high-quality data from hundreds abuse tests spanning numerous commercial and testing conditions. Data was gathered using a fractional runaway calorimeter breakdown heat mass that ejected, as well high-speed synchrotron radiography internal dynamic...
Airway closure is involved in adverse effects of mechanical ventilation under both general anesthesia and acute respiratory distress syndrome patients. However, direct evidence characterization individual airway lacking. Here, we studied the same peripheral airways intact lungs anesthetized mechanically ventilated rabbits, at baseline following lung injury, using high-resolution synchrotron phase-contrast CT.Laboratory animal investigation.European radiation facility.Six New-Zealand White...
Abstract Imaging the entire cardiomyocyte network in small animal hearts at single cell resolution is a formidable challenge. Optical microscopy provides sufficient contrast and 2d, however fails to deliver non-destructive 3d reconstructions with isotropic resolution. It requires several invasive preparation steps, which introduce structural artefacts, namely dehydration, physical slicing staining, or for case of light sheet also clearing tissue. Our goal provide hydrated murine hearts,...
Abstract We present an application of X-ray scattering tensor tomography with a random wavefront modulator to resolve the orientation microstructures in archaeological skeletal remains. experimentally investigated two fragments from different tissue types — cortical bone and root dentine commonly analyzed palaeoanthropological research. This study hints at potential advance methodologies for both research clinical applications.
Oil serves as both the high-temperature heating medium during deep-frying unit operations and a contributor to organoleptic properties of deep-fried foods. Its absorption is linked structural deformations that create pathways for oil enter food microstructure. This study proposes 4D imaging system (three spatial dimensions time) using fast synchrotron radiation tomography in-situ visualisation post-frying cooling understand mechanisms behind absorption. Using wheat flour dough model system,...
The detection system is a key part of any imaging station. Here the performance novel sCMOS-based installed at ID17 biomedical beamline European Synchrotron Radiation Facility and dedicated to high-resolution computed-tomography analysed. consists an X-ray–visible-light converter, visible-light optics PCO.Edge5.5 sCMOS detector. Measurements optical characteristics, linearity system, lag, modulation transfer function, normalized power spectrum, detective quantum efficiency photon curve are...
Abstract To understand the determinants of inhaled aerosol particle distribution and targeting in lung, knowledge regional deposition, lung morphology ventilation, is crucial. No single imaging modality allows acquisition all such data together. Here we assessed feasibility dual-energy synchrotron radiation to this end anesthetized rabbits; both normal (n = 6) following methacholine (MCH)-induced bronchoconstriction 6), a model asthma. We used K-edge subtraction CT (KES) quantitatively map...
Positive pressure ventilation exposes the lung to mechanical stresses that can exacerbate injury. The exact mechanism of this pathologic process remains elusive. goal study was describe recruitment/derecruitment at acinar length scales over short-time frames and test hypothesis interdependence between neighboring units determines spatial temporal distributions recruitment/derecruitment, using a computational model.Experimental animal study.International synchrotron radiation laboratory.Four...
All-solid-state batteries (ASSBs) are expected to be a relevant solution increase the energy density in lithium-ion battery (LiB) technology. However, management requires high-energy storage capacities, which make safety crucial issue. Unfortunately, it is difficult so far assess of nonfully mature technologies. In this paper, we describe methodology study thermal runaway wide range ASSB We specifically designed closed calorimeter used operando experiments with high-speed synchrotron X-ray...
All-solid-state-battery (ASSB) safety has rarely been studied at the cell scale. The first results underline that is improbable and should be investigated further. To best of our knowledge, propagation thermal runaway (TRP) never characterized experimentally battery pack A setup was specially designed to contain two runaways representative a configuration. Three key steps TRP were by high-speed X-ray radiography heat flow measurements: ignition, ending. Several tests carried out assess...
Battery safety design is important to consider from the individual Li-ion cell level of macro-system. On macro-level, failure in one single can lead propagation thermal runaway and rapidly set a whole battery pack on fire. Factors that impact outcome, such as model/chemistry electrical connection are here investigated using combination measurements. Several abusive tests were conducted, combining two different models (Molicel P42A LG M50, both 21700s) series parallel connections (16 per...
Abstract Mechanical ventilation can damage the lungs, a condition called Ventilator-Induced Lung Injury (VILI). However, mechanisms leading to VILI at microscopic scale remain poorly understood. Here we investigated within-tidal dynamics of cyclic recruitment/derecruitment (R/D) using synchrotron radiation phase-contrast imaging (PCI), and relation between R/D cell infiltration, in model Acute Respiratory Distress Syndrome 6 anaesthetized mechanically ventilated New-Zealand White rabbits....
X-ray directional dark-field imaging is a recent technique that can reveal sample's small-scale structural properties which are otherwise invisible in conventional system. In particular, detect and quantify the orientation of anisotropic structures. Here, we present an algorithm allows for extraction signal from speckle-based data. The experimental setup simple, as it requires only addition diffuser to full-field microscope setup. Sandpaper appropriate material hard x-ray regime. We propose...
All-solid-state batteries have been developed to increase energy density by replacing the lithiated graphite negative electrode a lithium metal foil and safety removing organic compounds. However, issues of these received little attention up now. The behavior reassembled all-solid-state battery under thermal stress was recorded X-ray radiography high-speed camera. runaway (TR) lasted about 5 ms, thus extremely fast reaction kinetics. In comparison, TR lithium-ion is 500 ms. Furthermore,...
The investigation of lithium-ion battery failures is a major challenge for personnel and equipment due to the associated hazards (thermal reaction, toxic gases explosions). To perform such experiments safely, abuse-test chamber has been developed installed at microtomography beamline ID19 European Synchrotron Radiation Facility (ESRF). provides capability robustly in situ abuse tests through heat-resistant gas-tight design flexible geometries configurations, including single-cell multi-cell...
Abstract The plating of lithium metal on the graphite electrode is a major degradation mechanism in lithium‐ion batteries (LIBs). It brings significant risk internal shortcircuit by penetration dendritic through separator, leading to short cycle life and safety issues. Understanding how when occurs crucial for development mitigation strategies, e. g. tuning electrolyte composition. Here we present an operando X‐ray tomographic microscopy (XTM) study directly monitor lithium/graphite cell....
We assessed the changes in regional lung function following instillation of surfactant a model respiratory distress syndrome (RDS) induced by whole lavage and mechanical ventilation eight anaesthetized, paralyzed, mechanically ventilated New Zealand White rabbits. Regional specific (sV̇) was measured K-edge subtraction synchrotron computed tomography during xenon washin. Lung regions were classified as poorly aerated (PA), normally (NA), or hyperinflated (HI) based on density. A functional...
BACKGROUND It is not well understood how different ventilation modes affect the regional distribution of ventilation, particularly within injured lung. OBJECTIVES We compared respiratory mechanics, lung aeration and specific ( ) distributions in healthy surfactant-depleted rabbits ventilated with pressure-regulated volume control (PRVC) mode a decelerating inspiratory flow or (VC) mode. DESIGN Randomised experimental study. ANIMALS AND INTERVENTIONS New Zealand white (n = 8) were...
High-power ultrasonic horns operating at low frequency are known to generate a cone-shaped cavitation bubble cloud beneath them. The exact physical processes resulting in the conical structure still unclear mainly due challenges associated with their visualization. Herein, we address onset of by exploiting high-speed X-ray phase contrast imaging. It reveals that cone formation is not immediate but results from three-step phenomenology: (i) inception and oscillation single bubbles, (ii)...
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INTRODUCTION: The mechanisms of lung inflation and deflation are only partially known. Ventilatory strategies to support function rely upon the idea that alveoli isotropic balloons progressively inflate or deflate pressure/volume curves derive by interplay critical opening pressures, closing history position inside lung. This notion has been recently challenged subpleural microscopy, magnetic resonance computed tomography. Phase-Contrast Synchrotron Radiation Computed Tomography (PC-SRCT)...
X-ray Phase Contrast Imaging (PCI) is an emerging modality that will be in the next few years available a wider range of preclinical set-ups. In this study, we compare imaging technique with conventional modalities osteoarthritis mouse model. contrast was performed on 6 post-mortem, monoiodoacetate-induced knees and control knees. The mice were then imaged using magnetic resonance micro computed tomography. Examples surrogate markers are reported: local distances within articular space,...
Abstract Ventilation is inhomogeneous in the lungs across species. It has been hypothesized that ventilation inhomogeneity largely determined by design of airway branching network. Because exchange gases at alveolar barrier more efficient when gas concentrations are evenly distributed subacinar length scales, it assumed a ‘functional unit’ exists within lung periphery, where concentration becomes uniform. On other hand, because morphology pulmonary airways and alveoli, distribution inhaled...
Modern ventilatory strategies are based on the assumption that lung terminal airspaces act as isotropic balloons progressively accommodate gas. Phase contrast synchrotron radiation computed tomography (PCSRCT) has recently challenged this concept, showing in healthy lungs, deflation mechanisms sequential de-recruitment of airspaces. Using PCSRCT scans an animal model acute respiratory distress syndrome (ARDS), study examined whether numerosity (ASnum) and dimension (ASdim) change during a...