A5083672016- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiation Dose and Imaging
- Boron Compounds in Chemistry
- Effects of Radiation Exposure
- Pancreatic and Hepatic Oncology Research
- Radiation Detection and Scintillator Technologies
- Brain Metastases and Treatment
- Cancer Treatment and Pharmacology
- Advances in Oncology and Radiotherapy
- Colorectal and Anal Carcinomas
- Nanoplatforms for cancer theranostics
- Radiation Effects and Dosimetry
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Nuclear Physics and Applications
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- Advanced X-ray and CT Imaging
- Meningioma and schwannoma management
- Cancer Research and Treatments
- Advanced MRI Techniques and Applications
- Cancer Genomics and Diagnostics
Centre François Baclesse
2018-2025
Centre Hospitalier Universitaire de Grenoble
2014-2024
Université Grenoble Alpes
2014-2023
Synchrotron Radiation for Biomedicine
2020-2022
Centre François Baclesse
2021
Inserm
2005-2021
European Synchrotron Radiation Facility
2003-2021
Centre Hospitalier Universitaire de Caen
2019
Centre de Radiothérapie Bayard
2008-2019
Laboratoire de Physique du Rayonnement et de la Lumière
2004-2019
The management of locally advanced (LA) pancreatic cancer patients remains controversial. To select who could benefit from chemoradiotherapy (CRT), the therapeutic strategy used by Groupe Coopérateur Multidisciplinaire en Oncologie (GERCOR) consisted initial chemotherapy (CT) for at least 3 months. decision to administer CRT or continue CT in nonprogressive was investigator's choice.Retrospective analysis outcome 181 with LA (76 women and 105 men; mean age, 61 years; range, 37 85 years)...
Data suggest selective internal radiotherapy (SIRT) in third-line or subsequent therapy for metastatic colorectal cancer has clinical benefit patients with liver metastases liver-dominant disease after chemotherapy. The FOXFIRE, SIRFLOX, and FOXFIRE-Global randomised studies evaluated the efficacy of combining first-line chemotherapy SIRT using yttrium-90 resin microspheres metastases. were designed combined analysis overall survival.
Brain metastasis impacts greatly on patients' quality of life and survival. The phase I NANO-RAD trial assessed the safety maximum tolerated dose systemic administration a novel gadolinium-based nanoparticle, AGuIX, in combination with whole brain radiotherapy patients multiple metastases not suitable for stereotactic radiotherapy.Patients measurable received escalating doses AGuIX nanoparticles (15, 30, 50, 75, or 100 mg/kg intravenously) day initiation WBRT (30 Gy 10 fractions) 5 cohorts 3...
Occurrence of multiple brain metastases is a critical evolution many cancers with significant neurological and overall survival consequences, despite new targeted therapy standard whole radiotherapy (WBRT). A gadolinium-based nanoparticle, AGuIX, has recently demonstrated its effectiveness as theranostic radiosensitiser agent in preclinical studies. The favourable toxicity profile animals administration simple intravenous injection motivated use patients this first human study.The NANO-RAD...
The use of radiosensitizing nanoparticles with both imaging and therapeutic properties on the same nano-object is regarded as a major promising approach to improve effectiveness radiotherapy. Here, we report MRI findings phase 1 clinical trial single intravenous administration Gd-based AGuIX nanoparticles, conducted in 15 patients four types brain metastases (melanoma, lung, colon, breast). were found accumulate increase image contrast all enhancements equivalent that clinically used agent....
Abstract High-grade gliomas are usually of poor prognosis, and conventional radiotherapy, even combined with chemotherapy, still fails to improve the survival patients. Here, we propose an innovative therapeutic approach combining synchrotron radiation cis-diamminedichloroplatinum (II) (CDDP). As suggested previously, monochromatic irradiation CDDP at 78.8 keV, just above 78.4 keV platinum absorption K-edge, leads enhanced photoelectric effect increased local toxicity. To select a particular...
This study was designed to experimentally evaluate the optimal X-ray energy for increasing radiation absorbed in tumours loaded with iodinated compounds, using photoelectric effect. SQ20B human cells were irradiated synchrotron monochromatic beam tuned at 32.8, 33.5, 50 and 70 keV. Two cell treatments compared control: suspended 10 mg ml−1 of iodine radiological contrast agent or pre-exposed μ M iodo-desoxyuridine (IUdR) 48 h. Our radiobiological end point clonogenic survival. Cells both...
One hundred fifty-seven patients referred to the Department of Radiation Oncology Hǒpital Tenon, Paris, France, between December 10, 1986 and 31, 1989 for total-body irradiation (TBI) were treated according following two techniques: (1) either in one fraction (1000 cGy administered midplane at L4 800 lungs) or (2) six fractions (1200 on 3 consecutive days 900 lungs). The randomized instantaneous dose rates, called LOW HIGH, single-dose (6 versus 15 cGy/min) hexafractionated (3 6 TBI groups....
This study reports the use of gadolinium-based AGuIX nanoparticles (NPs) as a theranostic tool for both image-guided radiation therapy and radiosensitization brain tumors.Pharmacokinetics regulatory toxicology investigations were performed on rodents. The NPs' tumor accumulation was studied by MRI before 6-MV irradiation.AGuIX NPs exhibited great safety profile. A single intravenous administration enabled delineation with T1 contrast enhancement up to 24 h, volume reduction when combined...
Abstract Purpose: The goal of the present study was to evaluate efficacy intracerebral (i.c.) administration carboplatin by means convection-enhanced delivery (CED) in combination with fractionated, external beam photon irradiation for treatment F98 glioma–bearing rats. Experimental Design: Carboplatin (20 μg/20 μL) administrated i.c. CED rats, 13 days after stereotactic implantation 103 tumor cells. One day following initiation CED, a 24-Gy X-ray dose administered three daily fractions 8 Gy...
Novel irradiation techniques are continuously introduced in radiotherapy to optimize the accuracy, security and clinical outcome of treatments. These changes could raise question discontinuity dosimetric presentation subsequent need for practice adjustments case significant modifications. This study proposes a comprehensive approach compare different tests whether their respective dose calculation algorithms give rise statistically differences treatment doses patient. Statistical...
Delivery of high-radiation doses to brain tumors via multiple arrays synchrotron X-ray microbeams permits huge therapeutic advantages. Brain tumor (9LGS)-bearing and normal rats were irradiated using a conventional, homogeneous Broad Beam (BB), or Microbeam Radiation Therapy (MRT), then studied by behavioral tests, MRI, histopathology. A valley dose 10 Gy deposited between microbeams, delivered single port, improved control median survival time tumor-bearing better than BB isodose. An...