A5089356253- Effects of Radiation Exposure
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Extracellular vesicles in disease
- Ultrasound and Hyperthermia Applications
- Carcinogens and Genotoxicity Assessment
- Metabolomics and Mass Spectrometry Studies
- Molecular Biology Techniques and Applications
- DNA Repair Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Bioinformatics and Genomic Networks
- Physical Activity and Health
- Thyroid Disorders and Treatments
- Glioma Diagnosis and Treatment
- Urological Disorders and Treatments
- Polyomavirus and related diseases
- Multiple Sclerosis Research Studies
- Statistical Methods in Clinical Trials
- Urinary Bladder and Prostate Research
- Genomic variations and chromosomal abnormalities
- Birth, Development, and Health
- Radiation Effects and Dosimetry
- Circadian rhythm and melatonin
Institut de Radioprotection et de Sûreté Nucléaire
2016-2025
CEA Paris-Saclay - Etablissement de Fontenay-aux-roses
2018-2022
Inserm
2012-2017
Université Paris-Saclay
2012-2017
Centre de recherche en Epidémiologie et Santé des Populations
2012-2016
Laboratoire d'études sur les monothéismes
2016
Institut Gustave Roussy
2012-2015
Université Paris-Sud
2015
Urology Team
2014
In the event of a radiological accident or incident, aim biological dosimetry is to convert yield specific biomarker exposure ionizing radiation into an absorbed dose. Since 1980s, various tools have been used deal with statistical procedures needed for dosimetry, and in general those who made several calculations different biomarkers were based on closed source software. Here we present new open program, Biodose Tools, that has developed under umbrella RENEB (Running European Network...
A radiological accident, whether from industrial, medical, or malicious origin, may result in localized exposure to high doses of ionizing radiations, leading the development local radiation injury (LRI), that evolve toward deep ulceration and necrosis skin underlying tissues. Early diagnosis is therefore crucial facilitate identification management LRI victims. Circulating microRNAs (miRNA) have been studied as potential diagnostic biomarkers several diseases including hematological defects...
A radiological accident may result in the development of a local skin radiation injury (LRI) which evolve, depending on dose, from dry desquamation to deep ulceration and necrosis through unpredictable inflammatory waves. Therefore, early diagnosis victims LRI is crucial for improving medical care efficiency. This preclinical study aims identify circulating metabolites as biomarkers associated with using C57BL/6J mouse model hind limb irradiation. More precisely, two independent mice cohorts...
To determine diagnostic precision with magnetic resonance (MR) imaging of the brain, most predictive MR features, and added value comparison previous data for diagnosis asymptomatic progressive multifocal leukoencephalopathy (PML) associated natalizumab (NTZ).This retrospective study was approved by institutional review board, written informed consent obtained. Eleven consecutive patients multiple sclerosis (MS) who had received a definitive NTZ-associated PML (NTZ PML, 18 brain lesions)...
Thyroid carcinoma is a frequent complication of childhood cancer radiotherapy. The dose response to thyroid radiation now well established, but the potential modifier effect other factors requires additional investigation.This study aimed investigate role modifiers response.We followed cohort 4338 5-year survivors solid treated before 1986 over an average 27 years. received by gland and some anatomical sites during radiotherapy was estimated after reconstruction actual conditions in which...
Abstract Objective Anorexia nervosa (AN) is associated with one of the highest mortality rates any psychiatric disorder but limited data were reported for those extremely severe malnutrition. This study aimed to estimate standardized ratio (SMR), investigate predictive factors and causes death among a sample patients AN admitted specialized clinical nutrition unit (CNU) because Methods Between 11/27/1997 01/15/2014, vital status was determined 384 at first time in CNU. Sociodemographic,...
In 2011, the International Commission on Radiological Protection (ICRP) recommended reducing occupational equivalent dose limit for lens of eye from 150 mSv/year to 20 mSv/year, averaged over five years, with no single year exceeding 50 mSv. With this recommendation, several important assumptions were made, such as lack rate effect, classification cataracts a tissue reaction threshold at 0.5 Gy, and progression minor opacities into vision-impairing cataracts. However, although new thresholds...
Abstract Background Human exposure to high doses of radiation resulting in acute syndrome and death can rapidly escalate a mass casualty catastrophe the event nuclear accidents or terrorism. The primary reason is that there presently no effective treatment option, especially for radiation-induced gastrointestinal syndrome. This results from disruption mucosal barrier integrity leading severe dehydration, blood loss, sepsis. In this study, we tested whether extracellular vesicles derived...
Abstract Accelerometers, devices that measure body movements, have become valuable tools for studying the fragmentation of rest-activity patterns, a core circadian rhythm dimension, using metrics such as inter-daily stability (IS), intradaily variability (IV), transition probability (TP), and self-similarity parameter (named $$\alpha$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mi>α</mml:mi> </mml:math> ). However, their use remains mainly empirical. Therefore, we...
Abstract The efficacy and side effects of radiotherapy (RT) depend on parameters like dose the volume irradiated tissue. RT induces modulations tumor immune microenvironment (TIME) that are dependent dose. Low (LDRT, i.e., single doses 0.5–2 Gy) has been shown to promote infiltration into tumor. Here we hypothesize partial irradiation combining immunostimulatory/non-lethal properties LDRT with cell killing/shrinkage high (HDRT) within same mass could enhance anti-tumor responses when...
<h3>BACKGROUND AND PURPOSE:</h3> Arterial spin-labeling and susceptibility-weighted imaging are 2 MR techniques that do not require gadolinium. The study aimed to assess the accuracy of arterial SWI combined for detecting intracranial arteriovenous shunting in comparison with conventional imaging. <h3>MATERIALS METHODS:</h3> Ninety-two consecutive patients a known (<i>n</i> = 24) or suspected 68) underwent digital subtraction angiography brain imaging, including spin-labeling/SWI...
Every year, millions of people around the world benefit from radiation therapy to treat cancers localized in pelvic area. Damage healthy tissue field can cause undesirable toxic effects leading gastrointestinal complications called disease. A change composition and/or function microbiota could contribute radiation-induced toxicity. In this study, we tested prophylactic effect a new generation probiotic like Faecalibacterium prausnitzii (F. prausnitzii) on acute colonic lesions. Experiments...
Bone sarcoma as a second malignancy is rare but highly fatal. The present knowledge about radiation-absorbed organ dose–response insufficient to predict the risks induced by radiation therapy techniques. objective of study was assess treatment-induced risk for bone following childhood cancer and particularly related radiotherapy. Therefore, retrospective cohort 4,171 survivors solid treated between 1942 1986 in France Britain has been followed prospectively. We collected detailed information...
Abstract Purpose To compare linac-based mono-isocentric radiosurgery with Brainlab Elements Multiple Brain Mets (MBM) SRS and the Gamma Knife using a specific statistical method to analyze dosimetric impact of target volume geometric characteristics. A dose fall-off analysis allowed evaluate Gradient Index relevancy for spillage characterization. Material methods Treatments were planned on twenty patients three nine brain metastases MBM 2.0 GammaPlan 11.0. Ninety-five ranging from 0.02 9.61...
Our purpose was to assess the out-of-field dose component related head scatter radiation in high-energy photon therapy beams and then derive a multisource model for this component. For scattered photons, several planar sources have been defined, with number, location tilt depending on complexity of field shape. In absence precise knowledge scattering characteristics, assumptions are made emission spectra intensity from measurements. Among these, Compton formula is used evaluate energy...
The objective of our study was to evaluate if the feces sign can be used predict successful nonoperative treatment or progression ischemia in patients with small-bowel obstruction (SBO) due adhesions.For this single-center retrospective observational involving a blinded independent review by two radiologists 237 consecutive CT examinations 216 SBO adhesions (age: mean, 70.9 years; median, 74 interquartile range, 62-84 years), location transition zone (TZ), number TZs, and presence relative...
Purpose: The main objective of radiobiology is to establish links between doses and radiation-induced biological effects. In this context, well-defined dosimetry protocols are crucial the determination experimental protocols. This work proposes a new protocol for cell irradiation in SARRP shows importance modification some parameters defined physical dose outcomes.Materials methods: Once all configuration were defined, measurements with ionization chambers EBT3 films performed evaluate rate...
Purpose In case of a mass-casualty radiological event, there would be need for networking to overcome surge limitations and quickly obtain homogeneous results (reported aberration frequencies or estimated doses) among biodosimetry laboratories. These must consistent within such network. Inter-laboratory comparisons (ILCs) are widely accepted achieve this homogeneity. At the European level, great effort has been made harmonize biological dosimetry laboratories, notably during MULTIBIODOSE...
<h3>BACKGROUND AND PURPOSE:</h3> The diagnosis of subacute subarachnoid hemorrhage is important because rebleeding may occur with subsequent life-threatening hemorrhage. Our aim was to determine the sensitivity 3D double inversion recovery sequence compared CT, 2D and FLAIR, T2*, SWI sequences for detection SAH. <h3>MATERIALS METHODS:</h3> This prospective study included 25 patients a CT-proved acute Brain imaging repeated between days 14 16 (mean, 14.75 days) after clinical onset MR (2D...