A5014793784- Carcinogens and Genotoxicity Assessment
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Radiation Therapy and Dosimetry
- Radiation Effects and Dosimetry
- DNA and Nucleic Acid Chemistry
- Plant Genetic and Mutation Studies
- Radiation Dose and Imaging
- Advanced Radiotherapy Techniques
- Retinoids in leukemia and cellular processes
- Chemical Reactions and Isotopes
- Cancer-related Molecular Pathways
- Glutathione Transferases and Polymorphisms
- Folate and B Vitamins Research
- Advanced Chemical Sensor Technologies
- Genomics, phytochemicals, and oxidative stress
- Pregnancy and preeclampsia studies
- Heat shock proteins research
- Bacillus and Francisella bacterial research
- Ultrasound and Hyperthermia Applications
- Laser Applications in Dentistry and Medicine
- biodegradable polymer synthesis and properties
- Cardiovascular Issues in Pregnancy
- PARP inhibition in cancer therapy
- Kruppel-like factors research
Sri Ramachandra Institute of Higher Education and Research
2014-2025
Periyar University
2024
TVS Motor Company (India)
2008
Rutgers New Jersey Medical School
2004-2007
Rutgers, The State University of New Jersey
2004-2007
Indira Gandhi Centre for Atomic Research
1997-2001
de Toledo, S. M., Asaad, N., Venkatachalam, P., Li, L., Howell, R. W., Spitz, D. and Azzam, E. I. Adaptive Responses to Low-Dose/Low-Dose-Rate γ Rays in Normal Human Fibroblasts: The Role of Growth Architecture Oxidative Metabolism. Radiat. Res. 166, 849–857 (2006).To investigate low-dose/low-dose-rate effects low-linear energy transfer (LET) ionizing radiation, we used γ-irradiated cells adapted grow a three-dimensional architecture that mimics cell growth vivo. We determined the cellular,...
To assess the association between polymorphisms in angiotensin converting enzyme and methylene tetrahydrofolate reductase genes recurrent pregnancy loss by a case-control study South Indian women.DNA was extracted from peripheral blood leukocytes of 104 women with Recurrent Pregnancy Loss (RPL) 120 controls. Genotyping ACE Insertion Deletion MTHFR C677T polymorphism were carried out PCR PCR-RFLP, respectively.No statistically significant difference observed distribution genotypes cases...
Purpose In case of a mass-casualty radiological event, there would be need for networking to overcome surge limitations and quickly obtain homogeneous results (reported aberration frequencies or estimated doses) among biodosimetry laboratories. These must consistent within such network. Inter-laboratory comparisons (ILCs) are widely accepted achieve this homogeneity. At the European level, great effort has been made harmonize biological dosimetry laboratories, notably during MULTIBIODOSE...
Purpose: To determine whether the bystander effects induced by chemotherapeutic agents are similar to those ionising radiation and analyse cell dependency, if any, in different human types such as normal lung fibroblasts (WI-38), bone marrow mesenchymal stem cells (hBMSC), adenocarcinoma (A-549, NCI-H23) peripheral blood lymphocytes (PBL).
Abstract Measurement of γ‐H2AX protein changes in the peripheral blood lymphocytes (PBL) individuals exposed to ionizing radiation is a simple, sensitive, and rapid assay for triage early marker dose estimation. The qualitative quantitative measurements were examined using flow cytometry microscopy. Whole isolated vitro between 0.1 5 Gy doses 60 Co γ‐radiation at rate 1 Gy/min. Radiation induced foci frequency ( n = 3) relative fluorescence intensity 7) PBL was measured 0.5 2 hrs...
While contradictory reports are available on the yield of dicentric chromosomes (DC) in blood samples stored at different temperature and stimulated to enter into cell cycle, various times gap followed by exposure, limited information is micronucleus (MN) assay. As scoring micronuclei frequency from lymphocytes exposed individuals an alternative gold standard DC assay for triage applications, we examined radiation induced MN delayed mitogenic stimulation after irradiation vitro. Peripheral...
Purpose: Cancer patients treated with radiomimetic drug bleomycin (BLM) have shown incidence of 7% second malignancy. Studies regarding BLM-induced genomic instability in bystander cells are scarce, and experiments grown on three-dimensional (3D) cultures to mimic the in-vivo condition never been attempted.
Purpose: It is important to understand the significance of alpha (α) radiation-induced bystander effects (RIBE) and its relative biological effectiveness (RBE); this because phenomenon not universal mechanism unclear RBE widely varying projected be very high. Materials methods: Isolated lymphocytes from healthy volunteers (n = 10) were exposed either low fluence α-particles (241Am), γ-rays (60Co), or X-rays (225 kVp 6 MV). Co-culture methodology was employed investigate (BEs). Chromosomal...
Purpose: Non-Targeted effects (NTE), such as bystander effect (BE) and genomic instability (GI) challenge central dogma of radiation biology. Moreover, there is a need to understand its universality in different type cells quality.Materials method: To study BE (primary secondary) GI Human adult dermal fibroblast (HADF) peripheral blood lymphocytes (PBL) were exposed low fluence 241Am alpha (α) particle 6 MV X-ray. The was carried out by means co-culture methodology after exposing the both...
Background : The intention of cancer chemotherapy is to control the growth cells using chemical agents. However, occurrence second malignancies has raised concerns, leading re-evaluation current strategy in use for chemotherapeutic Although mechanisms involved malignancy remain ambiguous, therapeutic-agent-induced non-DNA targeted effects like bystander response and genomic instability cannot be eliminated completely. Hence, Bleomycin (BLM) Neocarzinostatin (NCS), drugs with a mode action...