A5072744276- Porphyrin and Phthalocyanine Chemistry
- Metal complexes synthesis and properties
- Photodynamic Therapy Research Studies
- Vanadium and Halogenation Chemistry
- Effects of Radiation Exposure
- Carcinogens and Genotoxicity Assessment
- Sesame and Sesamin Research
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
- Phytochemicals and Medicinal Plants
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Circadian rhythm and melatonin
- Urological Disorders and Treatments
- Cancer Genomics and Diagnostics
- bioluminescence and chemiluminescence research
- Plant Genetic and Mutation Studies
- Urologic and reproductive health conditions
- Free Radicals and Antioxidants
- Ovarian function and disorders
- Microbial bioremediation and biosurfactants
- Click Chemistry and Applications
- Mitochondrial Function and Pathology
- Crystallography and molecular interactions
- Complementary and Alternative Medicine Studies
Government of Uttar Pradesh
2024
Indian Institute of Science Bangalore
2015-2023
University of Delhi
2022-2023
Central Research Institute
2020-2023
Government of India
2021-2023
All India Institute of Medical Sciences
2018-2023
National Institute of Ocean Technology
2021-2023
Ministry of Earth Sciences
2021-2023
Institute of Nuclear Medicine & Allied Sciences
2013-2022
Govind Ballabh Pant Hospital
2022
Ternary oxidovanadium(IV) complexes of curcumin (Hcur), dipicolylamine (dpa) base, and its derivatives having pendant noniodinated di-iodinated boron-dipyrromethene (BODIPY) moiety (L1 L2, respectively), namely, [VO(dpa)(cur)]ClO4 (1), [VO(L1)(cur)]ClO4 (2), [VO(L2)(cur)]ClO4 (3) their chloride salts (1a-3a) were prepared, characterized, studied for anticancer activity. The used biological studies due to aqueous solubility. Complex 1 was structurally characterized by single-crystal X-ray...
The bioessential nature of cobalt and the rich photochemistry its coordination complexes can be exploited to develop potential next-generation photochemotherapeutics. A series six novel mixed-ligand cobalt(III) formulation [Co(B)2(L)]ClO4 (1–6), where B is an N,N-donor phenanthroline base, namely, 1,10-phenanthroline (phen in 1 4), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq 2 5), dipyrido[3,2-a:2′,3′-c]phenazine (dppz 3 6), L O,O-donor dianionic ligand derived from catechol...
Trikatu Churna ( TC ) comprising Zingiber officinale rhizome, Piper longum , and nigrum fruit, is effective in treating liver diseases has high nutraceutical values. However, the efficacy of alcoholic disease (ALD) its mechanism remain largely unknown. This study evaluated hepatoprotective effects different doses as well to identify bioactive components determine their action against ethanol-induced ALD. A compound-target network analysis model was established potential compounds pathways...
The paper demonstrates the fabrication of sericin loaded hybrid polymeric composite nanofibrous scaffold and evaluation its cytocompatibilty in three human monocultures biocompatibility second degree burn wound model Wistar rats.
Protection of γ-ray-induced injury in hematopoietic and gastrointestinal (GI) systems is the rationale behind developing radioprotectors. The objective this study, therefore, was to investigate radioprotective efficacy mechanisms underlying sesamol amelioration GI mice. C57BL/6 male mice were pre-treated with a single dose (100 or 50 mg/kg, 30 min prior) through intraperitoneal route exposed LD50/30 (7.5 Gy) sublethal (5 γ-radiation. Thirty-day survival against 7.5 Gy monitored. Sesamol...
This study aimed to evaluate the cost-effectiveness of camrelizumab versus chemotherapy as second-line treatment for patients with advanced/metastatic esophageal squamous cell carcinoma (ESCC) from perspective Chinese healthcare system.
A deep-sea fungus Aspergillus sydowii BOBA1 isolated from marine sediment at a depth of 3000 m was capable degrading spent engine (SE) oil. The response immobilized fungi towards degradation elevated pressure studied in customized high reactors without any deviation simulating situ conditions. growth rate A. 0.1 MPa significantly different the 10 pressure. percentage reached 71.2 and 82.5% atmospheric conditions, respectively, within retention period 21 days. complete genome sequence...
Ionizing radiation exposure is harmful and at high doses can lead to acute hematopoietic syndrome. Therefore, agents that protect system are important for development of radioprotector. Sesamol a potential molecule radioprotector due its strong free radical scavenging antioxidant properties. In the present study, sesamol was evaluated role in DNA damage repair γ‐irradiated CB57BL/6 mice compared with amifostine. C57BL/6 male were administered 20 mg/kg (i.p.) followed by 2 Gy whole body...
Ionising radiation causes free radical-mediated damage in cellular DNA. This is manifested as chromosomal aberrations and micronuclei (MN) proliferating cells. Sesamol, present sesame seeds, has the potential to scavenge radicals; therefore, it can reduce radiation-induced cytogenetic The aim of this study was investigate radioprotective sesamol bone marrow cells mice related haematopoietic system against genotoxicity. A comparative with melatonin designed for assessing sesamol. C57BL/6 were...
The objective of this study was to evaluate organ-wise toxicological effects sesamol and determine the LD50 cut-off value GHS category following acute oral toxicity method OECD 423. An carried out in female C57BL/6 mice. Observations for physical behaviour measurements on haematology, biochemistry, histology vital organs were performed. In addition, genotoxicity assessment using comet micronuclei assays also Acute observed at 2000 mg/kg, while no adverse 300 mg/kg. mg/kg manifested as severe...
Abstract Measurement of γ‐H2AX protein changes in the peripheral blood lymphocytes (PBL) individuals exposed to ionizing radiation is a simple, sensitive, and rapid assay for triage early marker dose estimation. The qualitative quantitative measurements were examined using flow cytometry microscopy. Whole isolated vitro between 0.1 5 Gy doses 60 Co γ‐radiation at rate 1 Gy/min. Radiation induced foci frequency ( n = 3) relative fluorescence intensity 7) PBL was measured 0.5 2 hrs...
Targeted PDT by<sup>1</sup>O<sub>2</sub>at mtDNA crosslinking site of a BODIPY-appended VO<sup>2+</sup>complex in visible light.
Abstract Background Plant-derived homeopathic medicines (HMs) are cheap and commercially available but mechanistically less explored entities than conventional medicines. Purpose The aim of our study was to evaluate the impact selected plant-derived HMs derived from Berberis aquifolium (BA), vulgaris (BV), Mentha piperita (MP), Curcuma longa (CL), Cinchona officinalis (CO), Thuja occidentalis (TO) Hydrastis canadensis (HC) on cervical cancer (CaCx) cells in vitro. Methods We screened mother...