A5074837358- Porphyrin and Phthalocyanine Chemistry
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Luminescence and Fluorescent Materials
- Vanadium and Halogenation Chemistry
- Metal complexes synthesis and properties
- Molecular Sensors and Ion Detection
- Crystallography and molecular interactions
- Polyoxometalates: Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Chemical Thermodynamics and Molecular Structure
- Curcumin's Biomedical Applications
- Click Chemistry and Applications
- Oxidative Organic Chemistry Reactions
- Thermal and Kinetic Analysis
Indian Institute of Science Bangalore
2018-2024
Boron-dipyrromethene (BODIPY) dyes are promising photosensitizers for cellular imaging and photodynamic therapy (PDT) owing to their excellent photophysical properties the synthetically tunable core. Metalation provides a convenient way overcome drawbacks arising from low aqueous solubility. New photo-/redox-responsive Co(III) prodrug chaperones developed as anticancer PDT agents efficient delivery of red-light-active BODIPY dyes. The photobiological activity heteroleptic complexes derived...
The bioessential nature of cobalt and the rich photochemistry its coordination complexes can be exploited to develop potential next-generation photochemotherapeutics. A series six novel mixed-ligand cobalt(III) formulation [Co(B)2(L)]ClO4 (1–6), where B is an N,N-donor phenanthroline base, namely, 1,10-phenanthroline (phen in 1 4), dipyrido[3,2-d:2′,3′-f]quinoxaline (dpq 2 5), dipyrido[3,2-a:2′,3′-c]phenazine (dppz 3 6), L O,O-donor dianionic ligand derived from catechol...
A cisplatin-based platinum(iv) prodrug, [Pt(NH3)2Cl2(OH)(L1 )], having L1 as a red-light active boron-dipyrromethene (BODIPY) pendant, was synthesized and characterized its application chemo-cum-photodynamic therapy agent studied. Me-L1 the ligand precursor is structurally characterized. The complex displayed an intense absorption band near 650 nm (ε ∼ 8.8 × 104 dm3 mol-1 cm-1) in 1 : (v/v) DMSO/DPBS. It showed emission at 674 (λex = 630 nm) with fluorescence quantum yield (ΦF) value of...
Two multichromophoric homoleptic ruthenium(II) complexes [Ru(tpy-BODIPY)2]Cl2 (complexes 1 and 2, tpy = 4-phenyl-2,2:6,2-terpyridine, BODIPY boron-dipyrromethene) were prepared, characterized their phototherapeutic activity bioimaging properties studied. The having structural similarity differ only by a phenylethynyl linker, its overall influence on physicochemical photobiological behavior was evaluated. terpyridine-BODIPY ligand L1 structurally X-ray crystallography. showed intense...
Iron(III) complexes of a vitamin B 6 Schiff base and NNN ‐donor ligands with pendant boron‐dipyrromethene (BODIPY) moieties; namely, [Fe(L 1–3 )(L 4,5 )](NO 3 ) ( 1 – 4 ), where L is benzyl‐bis[(pyridin‐2‐yl)methyl]methanamine (bzdpa in 2 noniodinated BODIPY‐appended dipicolylamine ligand (in , the diiodinated BODIPY analogue base, namely 3‐hydroxy‐5(hydroxymethyl)‐4‐{[(2‐hydroxyphenyl)imino]methyl}‐2‐methylpyridine 5 2‐[(2‐hydroxyphenylimino)‐methyl]phenol as nonpyridoxal were prepared,...
Mixed-ligand oxidovanadium(IV) β-diketonates having NNN-donor dipicolylamine-conjugated to boron-dipyrromethene (BODIPY in L1) and diiodo-BODIPY (in L2) moieties, namely, [VO(L1)(acac)]Cl (1), [VO(L2)(acac)]Cl (2), [VO(L1)(dbm)]Cl (3), where acac dbm are monoanionic O,O-donor acetylacetone 1,3-diphenyl-1,3-propanedione, were prepared, characterized, tested for their photoinduced anticancer activity visible light. Complexes 1 2 structurally characterized as PF6– salts (1a 2a) by X-ray...
Abstract A perceived drawback of ruthenium(II) polypyridyl photosensitizers for phototherapeutic applications is their inadequate absorption in the visible region. Ru(II) dyads attached to light‐harvesting organic chromophores are studied address this issue. Biotin‐appended compounds having one chromophore, namely BODIPY (boron‐dipyrromethene) ( 1 ) and Ru(II)‐(tpy) 2 ), or a dyad system containing linked via diphenylacetylene linker 3 were prepared as photodetection agent photosensitizes...
Abstract Iron(III) complexes of curcumin (Hcur) having a tridentate NNN ‐donor dipicolylamine‐based ligand L 1 and its biotinylated analogue 2 , namely, [Fe(L )(cur)Cl] ( ) ), were prepared, characterized their photo‐induced cytotoxicity studied. The exhibited curcumin‐based absorption band near 430 nm emission maxima at 520 nm. Complex with biotin moiety showed enhanced cellular uptake higher compared to non‐biotin . visible light induced was studied in HeLa, MCF‐7 HepG2 cell lines....
To overcome the drawbacks associated with chemotherapeutic and porphyrin-based photodynamic therapy (PDT) agents, use of BODIPY (boron-dipyrromethene) scaffold has gained prominence towards designing new generation photosensitizers-cum-cellular imaging agents. However, their poor cell permeability limited solubility in aqueous medium inhibits in-vitro application organic form. This necessitates development metal-BODIPY conjugates improved physiological stability enhanced therapeutic...
The photophysical properties of boron-dipyrromethene (BODIPY) dyes have made them suitable for cellular imaging and photodynamic therapy (PDT). efficacy these can be augmented by designing their dibromo/diiodo derivatives. With that objective considering the better light stability dibromo derivative, ternary Co(III) complexes a tetradentate N,N,N,O-donor polypyridyl phenolate (HL) bidentate N,O-donor quinoxaline (HL1) its BODIPY (HL2) or dibromo-BODIPY (HL3) pendants, namely,...